Search
Search Results
-
Whole-mouse clearing and imaging at the cellular level with vDISCO
Homeostatic and pathological phenomena often affect multiple organs across the whole organism. Tissue clearing methods, together with recent advances...
-
Recording of cellular physiological histories along optically readable self-assembling protein chains
Observing cellular physiological histories is key to understanding normal and disease-related processes. Here we describe expression recording...
-
Crystal ribcage: a platform for probing real-time lung function at cellular resolution
Understanding the dynamic pathogenesis and treatment response in pulmonary diseases requires probing the lung at cellular resolution in real time....
-
Whole-cell patch-clamp recording and parameters
The patch-clamp technique represents an electrophysiology type of method. This is one of several insightful approaches with five major...
-
Functional network disorganization and cognitive decline following fractionated whole-brain radiation in mice
Cognitive dysfunction following radiotherapy (RT) is one of the most common complications associated with RT delivered to the brain, but the precise...
-
Bio-friendly long-term subcellular dynamic recording by self-supervised image enhancement microscopy
Fluorescence microscopy has become an indispensable tool for revealing the dynamic regulation of cells and organelles. However, stochastic noise...
-
Imaging brain tissue architecture across millimeter to nanometer scales
Map** the complex and dense arrangement of cells and their connectivity in brain tissue demands nanoscale spatial resolution imaging....
-
Alterations in immune cell heterogeneities in the brain of aged zebrafish using single-cell resolution
Immunocytes, including the microglia, are crucial in the neurodegenerative process in old people. However, the understanding of regarding microglia...
-
Fast optical recording of neuronal activity by three-dimensional custom-access serial holography
Optical recording of neuronal activity in three-dimensional (3D) brain circuits at cellular and millisecond resolution in vivo is essential for...
-
Simulations approaching data: cortical slow waves in inferred models of the whole hemisphere of mouse
The development of novel techniques to record wide-field brain activity enables estimation of data-driven models from thousands of recording channels...
-
Dense 4D nanoscale reconstruction of living brain tissue
Three-dimensional (3D) reconstruction of living brain tissue down to an individual synapse level would create opportunities for decoding the dynamics...
-
Integrating single-cell transcriptomics with cellular phenotypes: cell morphology, Ca2+ imaging and electrophysiology
I review recent technological advancements in coupling single-cell transcriptomics with cellular phenotypes including morphology, calcium signaling,...
-
Kirigami electronics for long-term electrophysiological recording of human neural organoids and assembloids
Realizing the full potential of organoids and assembloids to model neural development and disease will require improved methods for long-term,...
-
A positively tuned voltage indicator for extended electrical recordings in the brain
Genetically encoded voltage indicators (GEVIs) enable optical recording of electrical signals in the brain, providing subthreshold sensitivity and...
-
Cellular and Molecular Markers of Neuroinflammation and State of Cognitive Functions in a Delayed Period after Prolonged γ, n-Radiation of Mice at Low Doses
AbstractThe study was aimed at investigating the effect of low-dose rate (2.13 mGy/h) prolonged γ, n-irradiation at 0.05 and 0.5 Gy on the brain...
-
Large-scale cranial window for in vivo mouse brain imaging utilizing fluoropolymer nanosheet and light-curable resin
Two-photon microscopy enables in vivo imaging of neuronal activity in mammalian brains at high resolution. However, two-photon imaging tools for...
-
Measurements of cerebral microvascular blood flow, oxygenation, and morphology in a mouse model of whole-brain irradiation-induced cognitive impairment by two-photon microscopy and optical coherence tomography: evidence for microvascular injury in the cerebral white matter
Whole-brain irradiation (WBI, also known as whole-brain radiation therapy) is a mainstay treatment modality for patients with multiple brain...
-
Multimodal in vivo recording using transparent graphene microelectrodes illuminates spatiotemporal seizure dynamics at the microscale
Neurological disorders such as epilepsy arise from disrupted brain networks. Our capacity to treat these disorders is limited by our inability to map...
-
Visualization of metabolites and microbes at high spatial resolution using MALDI mass spectrometry imaging and in situ fluorescence labeling
Label-free molecular imaging techniques such as matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI) enable the direct...
-
Functional ultrasound localization microscopy reveals brain-wide neurovascular activity on a microscopic scale
The advent of neuroimaging has increased our understanding of brain function. While most brain-wide functional imaging modalities exploit...
