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Valproate modulates the activity of multidrug resistance efflux pumps, as a chemoresistance factor in gastric cancer cells
BackgroundDrug resistance is one of the most critical problems in gastric cancer therapy. This study was performed to investigate the valproic acid...
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HDACi Delivery Systems Based on Cellulose Valproate Nanoparticles
The ability of histone deacetylase inhibitors (HDACi) like valproic acid (VPA) as a therapeutic for inflammatory diseases or cancer has increased the...
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Valproate decreases transgenerationally blood pressure by affecting thyrotropin-releasing hormone promoter DNA methylation and gene expression in spontaneously hypertensive rat
Central TRH, a neuropeptide, is involved in cardiovascular regulation. We demonstrated that the overexpression of diencephalic TRH (dTRH) in SHR rats...
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Functional Assessment of Peripheral Cholinergic Neurotransmission in Rats with Fetal Valproate Syndrome
AbstractOne of the most widespread experimental models for studying the development of autism spectrum disorders (ASDs) and methods of their therapy...
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Rutin protects rat liver and kidney from sodium valproate-induce damage by attenuating oxidative stress, ER stress, inflammation, apoptosis and autophagy
BackgroundThe present study investigated the effects of rutin (RUT), which has various biological and pharmacological properties, on liver and kidney...
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Molecular Mechanisms of Valproic Acid Action on Signalling Systems and Brain Functions
AbstractValproic acid (valproate, VA) has been widely used as an antiepileptic agent for several decades, as well as in the treatment of...
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Sex-specific Behavioral Characteristics of Rats with Fetal Valproate Syndrome
AbstractBoth male and female Wistar rats with an experimental model of autism spectrum disorders induced by prenatal administration of valproate...
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Secondary metabolites produced by Macrophomina phaseolina, a fungal root endophyte of Brugmansia aurea, using classical and epigenetic manipulation approach
Endophytic fungi are rich sources of structurally complex chemical scaffolds with interesting biological activities. However, their metabolome is...
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Behavioral Effects of Afobazole in an Experimental Model of Autism Spectrum Disorders
AbstractThe study was conducted on a model of fetal valproate syndrome (FVS) induced by a single subcutaneous administration of sodium valproate...
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Serial KinderMiner (SKiM) discovers and annotates biomedical knowledge using co-occurrence and transformer models
BackgroundThe PubMed archive contains more than 34 million articles; consequently, it is becoming increasingly difficult for a biomedical researcher...
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Melatonin ameliorates sodium valproate-induced hepatotoxicity in rats
Valproic acid (VPA) is a anticonvulsant and mood-stabilizing agent used to treat epilepsy in patients of all ages. However, it can cause...
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Clinical Studies and Epi-Drugs in Various Cancer Types
Cancer is characterized by modifications in the epigenetic mechanisms and chromatin functions. Alterations in gene expression, as well as the...
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Phyto-Constituents as Potential Leads for the Development of Novel Antiepileptic Drugs
Epilepsy is the major cause of morbidity and mortality despite the availability of varied drugs. The current antiepileptic drugs (AEDs), however,...
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Updating an Overview of Teratology
In this chapter, the authors aim to update an overview of the principles of teratology, beginning with the definition of teratology, the critical...
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Epigenetic modifiers as inducer of bioactive secondary metabolites in fungi
Scientists are making efforts to search for new metabolites as they are essential lead molecules for the drug discovery, much required due to the...
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Abnormal mTOR Signaling Pathway Activity in Autism Spectrum Disorders: Prospects of Mechanism-Based Therapy
AbstractAutism spectrum disorder (ASD) is a developmental disorder characterized by the early onset of problems with communication, learning, and...
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Valproic Acid Increases the Level of Expression of BDNF, GDNF and THEIR Receptors in the Embryonic Brain of Mice and Inducts the Stereotype Behavior
AbstractThe model with prenatal administration of valproic acid is the most common for studying the mechanisms of development of autism in...
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Effects and mechanism of small molecule additives on recombinant protein in CHO cells
AbstractChinese hamster ovary (CHO) cells can produce proteins with complex structures and post-translational modifications which are similar to...
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Identification of a novel homozygous intron 3 splice site (A>T) mutation in the ARG1 gene in cerebral palsy pediatric cases from Odisha, India
BackgroundArginase enzyme is essential for the catalysis of the last step of the urea cycle, resulting in the conversion of l -arginine to l -ornithine...
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Safety and efficacy outcomes after intranasal administration of neural stem cells in cerebral palsy: a randomized phase 1/2 controlled trial
BackgroundNeural stem cells (NSCs) are believed to have the most therapeutic potential for neurological disorders because they can differentiate into...
