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A metabolic readout of the urine metabolome of COVID-19 patients
Analysis of urine samples from COVID-19 patients by 1 H NMR reveals important metabolic alterations due to SAR-CoV-2 infection. Previous studies have...
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In-depth characterisation of the urine metabolome in cats with and without urinary tract diseases
IntroductionOur understanding of the urine metabolome and its association with urinary tract disease is limited in cats.
ObjectivesWe conducted a...
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Acute changes in the metabolome following resistance exercise combined with intake of different protein sources (cricket, pea, whey)
IntroductionSeparately, both exercise and protein ingestion have been shown to alter the blood and urine metabolome. This study goes a step further...
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HPV-associated cervicovaginal microbiome and host metabolome characteristics
BackgroundCervicovaginal microbiome plays an important role in the persistence of HPV infection and subsequent disease development. However,...
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Urine Metabolomics Reveals Overlap** Metabolic Associations Between Preeclampsia and Gestational Diabetes
Pregnancy is associated with numerous metabolic adaptations to meet the demands of the growing foetus. These adaptations could be perturbed during...
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Urine and serum metabolomic analysis of endometrial cancer diagnosis and classification based on ultra-performance liquid chromatography mass spectrometry
ObjectiveThis study aimed to reveal the urinary and serum metabolic pattern of endometrial cancer (EC) and establish diagnostic models to identify EC...
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Transcriptomics and metabolomics of blood, urine and ovarian follicular fluid of yak at induced estrus stage
To gain a deeper understanding of the metabolic differences within and outside the body, as well as changes in transcription levels following estrus...
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Association between human blood metabolome and the risk of hypertension
Hypertension, commonly referred to as high blood pressure, is a chronic medical condition characterized by persistently elevated blood pressure...
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Associations of the placental metabolome with immune maturation up to one year of age in the Swedish NICE-cohort
IntroductionAllergies and other immune-mediated diseases are thought to result from incomplete maturation of the immune system early in life. We...
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Genome–microbiome interplay provides insight into the determinants of the human blood metabolome
Variation in the blood metabolome is intimately related to human health. However, few details are known about the interplay between genetics and the...
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Preterm birth is associated with xenobiotics and predicted by the vaginal metabolome
Spontaneous preterm birth (sPTB) is a leading cause of maternal and neonatal morbidity and mortality, yet its prevention and early risk...
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A new statistical workflow (R-packages based) to investigate associations between one variable of interest and the metabolome
IntroductionIn metabolomics, the investigation of associations between the metabolome and one trait of interest is a key research question. However,...
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Metabolome and transcriptome profiles in quinoa seedlings in response to potassium supply
BackgroundQuinoa ( Chenopodium quinoa Willd.) is a herb within the Quinoa subfamily of Amaranthaceae, with remarkable environmental adaptability. Its...
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Discovery of gene regulation mechanisms associated with uniconazole-induced cold tolerance in banana using integrated transcriptome and metabolome analysis
BackgroundThe gibberellic acid (GA) inhibitor, uniconazole, is a plant growth regulator commonly used in banana cultivation to promote dwarfing but...
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Development of metabolome extraction strategy for metabolite profiling of skin tissue
IntroductionChanges in skin phenotypic characteristics are based on skin tissue. The study of the metabolic changes in skin tissue can help...
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Impact of hypoxia and reoxygenation on the extra/intracellular metabolome and on transporter expression in a human kidney proximal tubular cell line
IntroductionIschemia-reperfusion injury (IRI) induces several perturbations that alter immediate kidney graft function after transplantation and may...
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Comparison of reversed-phase, hydrophilic interaction, and porous graphitic carbon chromatography columns for an untargeted toxicometabolomics study in pooled human liver microsomes, rat urine, and rat plasma
IntroductionUntargeted metabolomics studies are expected to cover a wide range of compound classes with high chemical diversity and complexity. Thus,...
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Feasibility of using volatile urine fingerprints for the differentiation of sexually transmitted infections
AbstractSexually transmitted infections (STIs) are a public health problem worldwide, and current diagnostic methods have certain limitations. In...
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LC/MS-based discrimination between plasma and urine metabolomic changes following exposure to ultraviolet radiation by using data modelling
IntroductionThis study sought to compare between metabolomic changes of human urine and plasma to investigate which one can be used as best tool to...
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Human metabolome variation along the upper intestinal tract
Most processing of the human diet occurs in the small intestine. Metabolites in the small intestine originate from host secretions, plus the ingested...
