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Enzymatic Reactions in Unusual Reaction Media
The performance of enzymatic reactions in unusual reaction media offers a wide range of possibilities. Polar and nonpolar organic solvents,...
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Unusual serological profile in hepatitis B virus (HBV) infection associated with a probable clinical case of acute exacerbation of pre-existing chronic HBV infection
BackgroundAcute or chronic HBV infection in an individual can be laboratory characterized according to the serological profile of the viral markers...
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Unusual Evolution of Cephalopod Tryptophan Indole-Lyases
Tryptophan indole-lyase (TIL), a pyridoxal-5-phosphate-dependent enzyme, catalyzes the hydrolysis of l -tryptophan ( l -Trp) to indole and ammonium...
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A tool to act blind? Object-assisted eye-covering as a self-handicap** behavior and social play signal in Balinese long-tailed macaques
Self-handicap** behaviors evolved as honest signals that reliably reflect the quality of their performers. In playful activities, self-handicap**...
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Kinetic Methods of Deducing Binding Mechanisms Involving Intrinsically Disordered Proteins
There are multiple examples of protein–protein interactions involving one intrinsically disordered protein region binding to an ordered protein...
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Impact of explicit area scaling on kinetic models involving multiple compartments
BackgroundComputational modelling of cell biological processes is a frequently used technique to analyse the underlying mechanisms and to generally...
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Camphor nitroimine: a key building block in unusual transformations and its applications in the synthesis of bioactive compounds
The development of new drugs requires a lot of time and high financial investments. It involves a research network in which there is the...
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XPD stalled on cross-linked DNA provides insight into damage verification
The superfamily 2 helicase XPD is a central component of the general transcription factor II H (TFIIH), which is essential for transcription and...
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A pH-dependent shift of redox cofactor specificity in a benzyl alcohol dehydrogenase of aromatoleum aromaticum EbN1
AbstractWe characterise a reversible bacterial zinc-containing benzyl alcohol dehydrogenase (BaDH) accepting either NAD + or NADP + as a redox...
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Sequential Amplification of Amino Acid Enantiomeric Excess by Conglomerate and Racemic Compound: Plausible Prebiotic Route Towards Homochirality
Some amino acids can crystallize from aqueous solution both as conglomerates and racemic compounds: under high supersaturation following rapid...
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Low phosphatase activity of LiaS and strong LiaR-DNA affinity explain the unusual LiaS to LiaR in vivo stoichiometry
BackgroundLiaRS mediates Bacillus subtilis response to cell envelope perturbations. A third protein, LiaF, has an inhibitory role over LiaRS in the...
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Soaring over open waters: horizontal winds provide lift to soaring migrants in weak thermal conditions
BackgroundFor soaring birds, the ability to benefit from variable airflow dynamics is crucial, especially while crossing natural barriers such as...
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Automatic Assembly and Calibration of Models of Enzymatic Reactions Based on Ordinary Differential Equations
Enzymatic reactions have been studied for more than a 100 years. Indeed, isolation of enzymes from biological materials is no longer the main source...
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Interrogating the configurational stability of atropisomers
Atropisomers are molecules whose stereogenicity arises from restricted rotation about a single bond. They are of current importance because of their...
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New insights into the molecular mechanism of rhodopsin retinitis pigmentosa from the biochemical and functional characterization of G90V, Y102H and I307N mutations
Mutations in the photoreceptor protein rhodopsin are known as one of the leading causes of retinal degeneration in humans. Two rhodopsin mutations,...
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Context-dependent DNA polymerization effects can masquerade as DNA modification signals
BackgroundSingle molecule measurements of DNA polymerization kinetics provide a sensitive means to detect both secondary structures in DNA and...
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A bacterial cold-active dye-decolorizing peroxidase from an Antarctic Pseudomonas strain
AbstractDyP (dye-decolorizing peroxidase) enzymes are hemeproteins that catalyze the H 2 O 2 -dependent oxidation of various molecules and also carry...
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Ordered Motions in the Nitric-Oxide Dioxygenase Mechanism of Flavohemoglobin and Assorted Globins with Tightly Coupled Reductases
Nitric-oxide dioxygenases (NODs) activate and combine O2 with NO to form nitrate. A variety of oxygen-binding hemoglobins with associated partner...
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Topological links in predicted protein complex structures reveal limitations of AlphaFold
AlphaFold is making great progress in protein structure prediction, not only for single-chain proteins but also for multi-chain protein complexes....
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Structure and function of an atypical homodimeric actin cap** protein from the malaria parasite
Apicomplexan parasites, such as Plasmodium spp., rely on an unusual actomyosin motor, termed glideosome, for motility and host cell invasion. The...
