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Novel protein complexes containing autophagy and UPS components regulate proteasome-dependent PARK2 recruitment onto mitochondria and PARK2-PARK6 activity during mitophagy
Autophagy is an evolutionarily conserved eukaryotic cellular mechanism through which cytosolic fragments, misfolded/aggregated proteins and...
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Global marine biosecurity and ship lay-ups: intensifying effects of trade disruptions
Recent global trade disruptions, due to blockage of the Suez Canal and cascading effects of COVID-19, have altered the movement patterns of...
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Timed use of digoxin prevents heart ischemia–reperfusion injury through a REV-ERBα–UPS signaling pathway
Myocardial ischemia–reperfusion injury (MIRI) induces life-threatening damages to the cardiac tissue, and pharmacological means to achieve...
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How Start-ups and Established Organisations Together Can Drive Meaningful Healthcare Innovation in Personalised Medicine and AI
While there is no cookbook recipe to develo** an artificial intelligence solution from conception to market launch in healthcare, some key...
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Safety first: das Ubiquitin-Proteasom-System (UPS) und die Photosynthese
The proteasome is essential for the control of protein turnover in the nucleus and the cytosol of eukaryotic cells. Chloroplasts and mitochondria...
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Climb ups or thumbs ups?
In postmodern times, social media is an integral part of informal sports like parkour. It potentially impacts physical activities as well as the...
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Correction to: Build-UPS and break-downs: metabolism impacts on proteostasis and aging
A Correction to this paper has been published: https://doi.org/10.1038/s41418-021-00800-4
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Learning to Find the “food beneath your feet”: Urban Foraging, Social-Meet-ups, and Mobile Social-Ecological Memory in Philadelphia, USA
Urban greenspaces contribute to the maintenance of social-ecological memory (SEM), or the knowledge, experiences, and practices a community develops...
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Build-UPS and break-downs: metabolism impacts on proteostasis and aging
Perturbation of metabolism elicits cellular stress which profoundly modulates the cellular proteome and thus protein homeostasis (proteostasis)....
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A randomized, non-comparative phase 2 study of neoadjuvant immune-checkpoint blockade in retroperitoneal dedifferentiated liposarcoma and extremity/truncal undifferentiated pleomorphic sarcoma
Based on the demonstrated clinical activity of immune-checkpoint blockade (ICB) in advanced dedifferentiated liposarcoma (DDLPS) and undifferentiated...
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Date pomace polysaccharide: ultrasonic-assisted deep eutectic solvent extraction, physicochemical properties, biological activities, gut microbiota modulation, and rheological properties
BackgroundThis study utilized ultrasonication-assisted green extraction techniques to explore the physicochemical, rheological, biological, and...
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PI3K/AKT/FOXO3a Pathway Induces Muscle Atrophy by Ubiquitin-Proteasome System and Autophagy System in COPD Rat Model
Muscle atrophy is a common extrapulmonary co-morbidity affecting about 20% of patients with COPD. However, the mechanism of muscle atrophy in COPD...
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The Role of Ubiquitin–Proteasome System in the Biology of Stem Cells
AbstractSelective degradation of cellular proteins by the ubiquitin–proteasome system (UPS) is one of the key regulatory mechanisms in eukaryotic...
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Temporal trade-off between territorial and thermoregulatory behaviors of a generalist lizard in a dry forest
When animals are exposed to higher-than-optimal temperatures, they are expected to thermoregulate by decreasing their activity and seeking cooler...
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Role of protein degradation systems in colorectal cancer
Protein degradation is essential for maintaining protein homeostasis. The ubiquitin‒proteasome system (UPS) and autophagy–lysosome system are the two...
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Induction of proteasomal activity in mammalian cells by lifespan-extending tRNA synthetase inhibitors
We have recently shown that multiple tRNA synthetase inhibitors can greatly increase lifespan in multiple models by acting through the conserved...
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Bacterial profile, antimicrobial resistance, and molecular detection of ESBL and quinolone resistance gene of uropathogens causing urinary tract infection in the southeastern part of Bangladesh
Humans frequently contract urinary tract infections (UTIs), which can be brought on by uropathogens (UPs) that are multi-drug resistant. Treatment...
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Genetic diversity, transcript heterogeneity and allele mining of TaSKP1-6B-4 gene variants across diverse genotypes under terminal heat stress and genome wide characterization of TaSKP1 gene family from bread wheat (Triticum aestivum L.)
SKP1 (S-phase kinase protein1) is an essential regulatory component of SCF (Skp1-cullin-F-box) E3 ubiquitin ligases involved in maintenance of...
