Search
Search Results
-
Measuring Protein Tyrosine Phosphatase Activity Dependent on SH2 Domain-Mediated Regulation
Src-homology-2 (SH2) domains bind selectively to phosphotyrosine (pTyr) residues located in target binding proteins; therefore, they are key elements...
-
Protein tyrosine phosphatase PTPRO represses lung adenocarcinoma progression by inducing mitochondria-dependent apoptosis and restraining tumor metastasis
Emerging evidence indicates that protein activities regulated by receptor protein tyrosine phosphatases (RPTPs) are crucial for a variety of cellular...
-
Low molecular weight protein phosphatase APH mediates tyrosine dephosphorylation and ABA response in Arabidopsis.
Low molecular weight protein tyrosine phosphatase (LWM-PTP), also known as acid phosphatase, is a highly conserved tyrosine phosphatase in living...
-
SHP-1 Protein Tyrosine Phosphatase Affects Early Postnatal Bone Development in Mice
The Src homology region 2 domain-containing phosphatase-1 (SHP-1) is an intracellular tyrosine phosphatase that plays a negative regulatory role in...
-
Determination of promising inhibitors for N-SH2 domain of SHP2 tyrosine phosphatase: an in silico study
There are many genes that produce proteins related to diseases and these proteins can be targeted with drugs as a potential therapeutic approach....
-
Development and validation of machine learning models for the prediction of SH-2 containing protein tyrosine phosphatase 2 inhibitors
Discovery and development of a new drug to the market is a highly challenging and resource consuming process. Although, modern drug discovery...
-
Detection of Cellular Target Engagement for Small-Molecule Modulators of Striatal-Enriched Protein Tyrosine Phosphatase (STEP)
Striatal-enriched protein tyrosine phosphatase (STEP) is a brain-specific enzyme that regulates the signaling molecules that control synaptic...
-
Loss of protein tyrosine phosphatase receptor delta PTPRD increases the number of cortical neurons, impairs synaptic function and induces autistic-like behaviors in adult mice
BackgroundThe brain cortex is responsible for many higher-level cognitive functions. Disruptions during cortical development have long-lasting...
-
Characterization of a putative metal-dependent PTP-like phosphatase from Lactobacillus helveticus 2126
To date, there are very limited reports on sequence analysis and structure-based molecular modeling of phosphatases produced by probiotic bacteria....
-
Discovery of inhibitors targeting protein tyrosine phosphatase 1B using a combined virtual screening approach
Protein tyrosine phosphatase 1B (PTP1B) acts as a therapeutic target for type 2 diabetes. However, the major challenges of PTP1B drug discovery are...
-
Inhibition of protein tyrosine phosphatase improves mitochondrial bioenergetics and dynamics, reduces oxidative stress, and enhances adipogenic differentiation potential in metabolically impaired progenitor stem cells
BackgroundProtein tyrosine phosphatase 1B (PTP1B) and low molecular weight protein tyrosine phosphatase (LMPTP) are implicated in the development of...
-
The tyrosine phosphatase SHP2 increases robustness and information transfer within IL-6-induced JAK/STAT signalling
BackgroundCell-to-cell heterogeneity is an inherent feature of multicellular organisms and is central in all physiological and pathophysiological...
-
Protein tyrosine phosphatase non-receptor type 12 (PTPN12), negatively regulated by miR-106a-5p, suppresses the progression of hepatocellular carcinoma
Protein tyrosine phosphatase non-receptor type 12 (PTPN12) is abnormally expressed in many human cancers. However, its role in hepatocellular...
-
Protein Phosphatase Signaling in Cardiac Myocytes
A delicate balance of protein phosphorylation, performed by protein kinases, and dephosphorylation, performed by protein phosphatases, is required...
-
Atomistic ensemble of active SHP2 phosphatase
SHP2 phosphatase plays an important role in regulating several intracellular signaling pathways. Pathogenic mutations of SHP2 cause developmental...
-
Phosphorylation at tyrosine 317 and 508 are crucial for PIK3CA/p110α to promote CRC tumorigenesis
BackgroundPI3K/AKT signaling pathway plays important role in tumorigenesis of human cancer. Protein phosphorylation is crucial for signaling...
-
Deficiency of the Src homology phosphatase 2 in podocytes is associated with renoprotective effects in mice under hyperglycemia
Diabetic nephropathy (DN) is a significant complication of diabetes and the leading cause of end-stage renal disease. Hyperglycemia-induced...
-
Low molecular weight protein tyrosine phosphatase as signaling hub of cancer hallmarks
In the past decade, significant progress has been made in understanding the role of protein tyrosine phosphatase as a positive regulator of tumor...
-
AXL receptor tyrosine kinase modulates gonadotropin-releasing hormone receptor signaling
BackgroundGonadotropin-releasing hormone (GnRH) receptors are essential for reproduction and are expressed in numerous urogenital, reproductive, and...
