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Predicting Type III Effector Proteins Using the Effectidor Web Server
Various Gram-negative bacteria use secretion systems to secrete effector proteins that manipulate host biochemical pathways to their benefit. We and...
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Cryo-EM structure and protease activity of the type III-E CRISPR-Cas effector
The recently discovered type III-E CRISPR-Cas effector Cas7-11 shows promise when used as an RNA manipulation tool, but its structure and the...
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Type III secretion system effector YfiD inhibits the activation of host poly(ADP-ribose) polymerase-1 to promote bacterial infection
Modulation of cell death is a powerful strategy employed by pathogenic bacteria to evade host immune clearance and occupy profitable replication...
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Effector Translocation Assay: Differential Solubilization
The identification of effector proteins delivered into mammalian host cells by bacterial pathogens possessing syringe-like nanomachines is an...
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A self-assembling split Nano luciferase-based assay for investigating Pseudomonas syringae effector secretion
Many Gram-negative pathogens employ the type III secretion system (T3SS) to deliver effector proteins into host cells, thereby modulating host...
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Genome wide analysis revealed conserved domains involved in the effector discrimination of bacterial type VI secretion system
Type VI secretion systems (T6SSs) deliver effectors into target cells. Besides structural and effector proteins, many other proteins, such as...
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ExoU: A cytotoxin delivered by the type III secretion system of Pseudomonas aeruginosa
ExoU is a potent cytotoxin that is injected into host cells by the type III secretion system of Pseudomonas aeruginosa. It has recently been shown to...
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Monitoring Effector Translocation with the TEM-1 Beta-Lactamase Reporter System: From Endpoint to Time Course Analysis
Among the bacterial secretion systems, the Type III, IV, and VI secretion systems enable bacteria to secrete proteins directly into a target cell....
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Comparative transcriptomics and multiple phytohormone profiling reveals the molecular immune response of Arabidopsis thaliana to the pathogen Ralstonia solanacearum type III effector RipN
Ralstonia solanacearum , a causal agent of bacterial wilt, is one of the most destructive plant pathogens worldwide. R. solanacearum infects its host...
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A unique effector secreted by Pseudozyma flocculosa mediates its biocontrol activity
BackgroundPseudozyma flocculosa is a highly efficient biocontrol agent (BCA) of powdery mildews whose mode of action remains elusive. It is known to...
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The Phytophthora parasitica effector AVH195 interacts with ATG8, attenuates host autophagy, and promotes biotrophic infection
BackgroundPlant pathogens secrete effector proteins into host cells to suppress immune responses and manipulate fundamental cellular processes. One...
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Cytosolic sorting platform complexes shuttle type III secretion system effectors to the injectisome in Yersinia enterocolitica
Bacteria use type III secretion injectisomes to inject effector proteins into eukaryotic target cells. Recruitment of effectors to the machinery and...
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Broad-spectrum ubiquitin/ubiquitin-like deconjugation activity of the rhizobial effector NopD from Bradyrhizobium (sp. XS1150)
The post-translational modification of proteins by ubiquitin-like modifiers (UbLs), such as SUMO, ubiquitin, and Nedd8, regulates a vast array of...
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Prediction of Effector Proteins from Trichoderma longibrachiatum Through Transcriptome Sequencing
Trichoderma longibrachiatum SMF2 is an important biocontrol strain isolated by our group that can promote plant growth and induce plant disease...
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Fc-γR-dependent antibody effector functions are required for vaccine-mediated protection against antigen-shifted variants of SARS-CoV-2
Emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with antigenic changes in the spike protein are neutralized less...
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Toxoplasma protein export and effector function
Toxoplasma gondii is a single-celled eukaryotic parasite with a considerable host range that must invade the cells of warm-blooded hosts to survive...
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Elucidating the zinc-binding proteome of Fusarium oxysporum f. sp. lycopersici with particular emphasis on zinc-binding effector proteins
Fusarium oxysporum f. sp. lycopersici is a soil-borne phytopathogenic species which causes vascular wilt disease in the Solanum lycopersicum ...
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Quantifying Substrate Protein Secretion via the Type III Secretion System of the Bacterial Flagellum
Protein transport across the cytoplasmic membrane is coupled to energy derived from ATP hydrolysis or the proton motive force. A sophisticated,...
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Prevalence of Type III Secretion System (T3SS) and Biofilm Development in Genetically Heterogeneous Clinical Isolates of Pseudomonas aeruginosa from Nigeria
Pseudomonas aeruginosa infection in seriously ill patients is a major concern due to its ability to form biofilm and secrete effector toxins. There...
