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Rapid, tunable, and multiplexed detection of RNA using convective array PCR
Detection of RNA targets is typically achieved through RT-qPCR or RNAseq. RT-qPCR is rapid but limited in number and complexity of targets detected,...
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Tunable pH Sensitive Lipoplexes
To provide long circulating nanoparticles able to carry a gene to tumor cells, we have designed anionic pegylated lipoplexes which are pH sensitive....
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Tunable PhenoCycler imaging of the murine pre-clinical tumour microenvironments
BackgroundThe tumour microenvironment (TME) consists of tumour-supportive immune cells, endothelial cells, and fibroblasts. PhenoCycler, a high-plex...
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Cerebral organoids display dynamic clonal growth and tunable tissue replenishment
During brain development, neural progenitors expand through symmetric divisions before giving rise to differentiating cell types via asymmetric...
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Controlling the Potency of T Cell Activation Using an Optically Tunable Chimeric Antigen Receptor
The ability of biological systems to convert inputs from their environment into information to guide future decisions is central to life and a matter...
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Size-tunable Sargassum polycystum mediated synthesis of silver nanoparticles and its larvicidal effect on Aedes aegypti
One-pot green synthesis of silver nanoparticles (AgNPs) utilising marine brown seaweed ( Sargassum polycystum ) extract was developed. In this study,...
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Highly tunable TetR-dependent target gene expression in the acetic acid bacterium Gluconobacter oxydans
AbstractFor the acetic acid bacterium (AAB) Gluconobacter oxydans only recently the first tight system for regulatable target gene expression became...
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MOF-derived nanoporous carbons with diverse tunable nanoarchitectures
Metal-organic frameworks (MOFs), or porous coordination polymers, are crystalline porous materials formed by coordination bonding between inorganic...
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Engineering Shape-Controlled Microtissues on Compliant Hydrogels with Tunable Rigidity and Extracellular Matrix Ligands
In vitro models that recapitulate key aspects of native tissue architecture and the physical microenvironment are emerging systems for modeling...
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Cascade biocatalysis for production of enantiopure (S)-2-hydroxybutyric acid using recombinant Escherichia coli with a tunable multi-enzyme-coordinate expression system
Racemize 2-hydroxybutyric acid is usually synthesized by organic methods and needs additional deracemization to obtain optically pure enantiomers for...
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An inducible CRISPRi circuit for tunable dynamic regulation of gene expression in Saccharopolyspora erythraea
Actinomyces are gram-positive bacteria known for their valuable secondary metabolites. Redirecting metabolic flux towards desired products in...
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A tunable anthranilate-inducible gene expression system for Pseudomonas species
AbstractPseudomonads are among the most common bacteria in soils, limnic ecosystems, and human, animal, or plant host environments, including...
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Fabrication of gelatin microspheres containing ammonium hydrogen carbonate for the tunable release of herbicide
The major challenge in utilizing pesticides lies in identifying the precise application that would improve the efficiency of these pesticides and...
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Construction of a switchable synthetic Escherichia coli for aromatic amino acids by a tunable switch
Escherichia coli , a model microorganism for which convenient metabolic engineering tools are available and that grows quickly in cheap media, has...
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Scalable Liposome Synthesis by High Aspect Ratio Microfluidic Flow Focusing
Microfluidic flow focusing provides an efficient approach to the generation of nanoscale lipid vesicles of tunable size and low size variance....
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A tunable l-arabinose-inducible expression plasmid for the acetic acid bacterium Gluconobacter oxydans
AbstractThe acetic acid bacterium (AAB) Gluconobacter oxydans incompletely oxidizes a wide variety of carbohydrates and is therefore used...
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Scanning single molecule localization microscopy (scanSMLM) for super-resolution volume imaging
Over the last decade, single-molecule localization microscopy (SMLM) has developed into a set of powerful techniques that have improved spatial...
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The molecular basis for cellular function of intrinsically disordered protein regions
Intrinsically disordered protein regions exist in a collection of dynamic interconverting conformations that lack a stable 3D structure. These...
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Identification and Functional Characterization of cis-Regulatory Elements of Key Photorespiratory Genes in Response to Short-Term Abiotic Stress Conditions
The cis-regulatory elements (CREs) are the short stretches of noncoding DNA upstream of a gene, which play a critical role in fine-tuning gene...