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A Tumor Homing Peptide-Conjugated Poly(epsilon-lysine) Delivery System for Improved Antitumor Drug Loading and Targeting
The main challenges with conventional chemotherapeutic drugs are their non-selective toxicity and limited targeting abilities. Hence, it is...
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Enhancing the Stability of Tumor Homing LyP-1 Peptide Using Cyclization and Retro Grafting Strategies
Anticancer peptide therapeutics are promising candidates for cancer treatment as they are highly specific to their targets and can have tumor-homing...
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A Computational Predictor for Accurate Identification of Tumor Homing Peptides by Integrating Sequential and Deep BiLSTM Features
Cancer remains a severe illness, and current research indicates that tumor homing peptides (THPs) play an important part in cancer therapy. The...
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Tumor-specific intracellular delivery: peptide-guided transport of a catalytic toxin
There continues to be a need for cancer-specific ligands that can deliver a wide variety of therapeutic cargos. Ligands demonstrating both...
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Synthesis and evaluation of tumor-homing peptides for targeting prostate cancer
High toxicity caused by chemotherapeutic drugs and the acquisition of drug resistance by cancer cells are the major drawbacks in cancer therapy. A...
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Enhancing mesenchymal stem cell survival and homing capability to improve cell engraftment efficacy for liver diseases
Although mesenchymal stem cell (MSC) transplantation provides an alternative strategy for end-stage liver disease (ESLD), further widespread...
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Antimicrobial Assay with Peptide Based Hydrogels
Recent developments in the peptide design strategies have contributed to the functional evolution of antimicrobial peptides as possible alternatives...
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Mesenchymal stem cell homing to improve therapeutic efficacy in liver disease
Mesenchymal stem cell (MSC) transplantation, as an alternative strategy to orthotopic liver transplantation, has been evaluated for treating...
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Targeting prostate cancer with docetaxel-loaded peptide 563-conjugated PEtOx-co-PEI30%-b-PCL polymeric micelle nanocarriers
Prostate cancer is a global disease that negatively affects the quality of life. Although various strategies against prostate cancer have been...
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Stromal cells in the tumor microenvironment: accomplices of tumor progression?
The tumor microenvironment (TME) is made up of cells and extracellular matrix (non-cellular component), and cellular components include cancer cells...
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Anti-cancer peptide-based therapeutic strategies in solid tumors
BackgroundNowadays, conventional medical treatments such as surgery, radiotherapy, and chemotherapy cannot cure all types of cancer. A promising...
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An investigation of binding interactions of tumor-targeted peptide conjugated polyphenols with the kinase domain of ephrin B4 and B2 receptors
AbstractRecent studies have shown that Ephrin receptors may be upregulated in several types of cancers including breast, ovarian and endometrial...
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A single nucleotide mutation drastically increases the expression of tumor-homing NGR-TNFα in the E. coli M15-pQE30 system by improving gene transcription
AbstractDue to their potent immune stimulation, tumor necrosis factor alpha (TNFα) variants with tumor-homing activity are attractive as novel...
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Engineering biomimetic nanosystem targeting multiple tumor radioresistance hallmarks for enhanced radiotherapy
Tumor cells establish a robust self-defense system characterized by hypoxia, antioxidant overexpression, DNA damage repair, and so forth to resist...
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Peptide cargo administration: current state and applications
AbstractEffective delivery of drug molecules to the target site is a challenging task. In the last decade, several innovations in the drug delivery...
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Design and Synthesis of a Peptide-Based Glioma-Targeted Drug Delivery Vector gHope2
In the current chapter, we are detailing the synthesis path of a tumor-targeted, CPP-functionalized chemotherapeutic drug, as well as in vitro...
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A Cicada Antimicrobial Peptide, Cryptonin, Exhibits Potent Antitumor Activity by Necrosis on Human Melanoma Cells
Antimicrobial peptides are the first defense molecules against various organisms such as bacteria, fungi and are produced by different organisms. In...
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Antibiotic-Peptide Conjugation Against Multi-drug Resistant Pathogens: A Comprehensive Review for Therapeutics and Drug Delivery Strategies
A global public health crisis has been created by the emergence of serious infectious illnesses, the rising prevalence of infections that are...
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LGBM-ACp: an ensemble model for anticancer peptide prediction and in silico screening with potential drug targets
Conventional cancer therapies are highly expensive and have serious complications. An alternative approach now emphasizes on the development of...
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Potential links between the microbiota and T cell immunity determine the tumor cell fate
The central role of the microbiota as a pivotal factor regulating anti-tumor immune responses has recently been appreciated. Increasing evidence has...
