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Tryptophan Metabolism: A New Look at the Role of Tryptophan Derivatives in the Human Body
Abstract —In modern scientific literature, close attention is paid to the biological role of tryptophan catabolites both in normal conditions and in...
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Dietary fibre directs microbial tryptophan metabolism via metabolic interactions in the gut microbiota
Tryptophan is catabolized by gut microorganisms resulting in a wide range of metabolites implicated in both beneficial and adverse host effects. How...
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Ochratoxin A induces abnormal tryptophan metabolism in the intestine and liver to activate AMPK signaling pathway
BackgroundOchratoxin A (OTA) is a mycotoxin widely present in raw food and feed materials and is mainly produced by Aspergillus ochraceus and Penicill...
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Tryptophan metabolism in digestive system tumors: unraveling the pathways and implications
Tryptophan (Trp) metabolism plays a crucial role in influencing the development of digestive system tumors. Dysregulation of Trp and its metabolites...
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Genetic regulation of l-tryptophan metabolism in Psilocybe mexicana supports psilocybin biosynthesis
BackgroundAlthough Basidiomycota produce pharmaceutically and ecologically relevant natural products, knowledge of how they coordinate their primary...
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Improvement of insulin sensitivity by dietary fiber consumption during late pregnant sows is associated with gut microbiota regulation of tryptophan metabolism
BackgroundDietary fiber (DF) consumption was reported to improve insulin sensitivity, change the tryptophan metabolism, and alter the gut microbiota....
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Stable isotope-assisted metabolite profiling reveals new insights into L-tryptophan chemotrophic metabolism of Rubrivivax benzoatilyticus
Anoxygenic photosynthetic bacteria (APB) are metabolically versatile, capable of surviving with an extended range of carbon and nitrogen sources....
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Multi-omics analysis reveals changes in tryptophan and cholesterol metabolism before and after sexual maturation in captive macaques
Rhesus macaques ( Macaca mulatta , RMs) are widely used in sexual maturation studies due to their high genetic and physiological similarity to humans....
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Untargeted metabolomics analysis reveals Mycobacterium tuberculosis strain H37Rv specifically induces tryptophan metabolism in human macrophages
BackgroundTuberculosis (TB) caused by Mycobacterium tuberculosis ( M. tb ) remains a global health issue. The characterized virulent M. tb H37Rv,...
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Tryptophan regulates bile and nitrogen metabolism in two pig gut lactobacilli species in vitro based on metabolomics study
Research has demonstrated that tryptophan (Trp) regulated the composition and metabolism of the gut microbiota. However, the detailed mode of action...
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Emerging effects of tryptophan pathway metabolites and intestinal microbiota on metabolism and intestinal function
The metabolism of dietary tryptophan occurs locally in the gut primarily via host enzymes, with ~ 5% metabolized by gut microbes. Three major...
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Excessive dietary L-tryptophan regulated amino acids metabolism and serotonin signaling in the colon of weaning piglets with acetate-induced gut inflammation
L-Tryptophan (Trp) was shown to improve the gut barrier and growth of weaning piglets. However, whether excessive dietary Trp regulates amino acids...
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Aryl hydrocarbon receptor dependent anti-inflammation and neuroprotective effects of tryptophan metabolites on retinal ischemia/reperfusion injury
Glaucoma is the major cause of irreversible blindness in the world characterized by progressive retinal neurodegeneration, in which local...
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Common alterations in plasma free amino acid profiles and gut microbiota-derived tryptophan metabolites of five types of cancer patients
Amino acids not only play a vital role in the synthesis of biological molecules such as proteins in cancer malignant cells, they are also essential...
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Gut microbiota-derived tryptophan metabolites alleviate liver injury via AhR/Nrf2 activation in pyrrolizidine alkaloids-induced sinusoidal obstruction syndrome
Background and aimsHepatic sinusoidal obstruction syndrome (HSOS) is caused by toxic injury, such as pyrrolizidine alkaloids, to the liver sinusoidal...
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Tryptophan metabolism drives dynamic immunosuppressive myeloid states in IDH-mutant gliomas
The dynamics and phenotypes of intratumoral myeloid cells during tumor progression are poorly understood. Here we define myeloid cellular states in...
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Metagenomics-based inference of microbial metabolism towards neuroactive amino acids and the response to antibiotics in piglet colon
Gut-derived neuroactive metabolites from amino acids perform a broad range of physiological roles in the body. However, the interaction between...
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Discrete interplay of gut microbiota L-tryptophan metabolites in host biology and disease
The gut microbiota and the host maintain a conjoint relationship and together achieve optimal physiology via a multitude of interactive signalling...
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Unusual Evolution of Cephalopod Tryptophan Indole-Lyases
Tryptophan indole-lyase (TIL), a pyridoxal-5-phosphate-dependent enzyme, catalyzes the hydrolysis of l -tryptophan ( l -Trp) to indole and ammonium...
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Tryptophanyl-tRNA synthetase-1 (WARS-1) depletion and high tryptophan concentration lead to genomic instability in Caenorhabditis elegans
The fidelity of translation is ensured by a family of proteins named aminoacyl-tRNA synthetases (ARSs), making them crucial for development and...
