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Synthesis and Evaluation of Antibacterial Properties of 1,2,3-Triazole Sulfonamide Derivatives
AbstractObjective: Currently, microbial infections are a global threat to human health, and there is an urgent need to develop new and effective...
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An insight on medicinal attributes of 1,2,3‐ and 1,2,4‐triazole derivatives as alpha-amylase and alpha-glucosidase inhibitors
Diabetes Mellitus (DM) is the globe’s common leading disease which is caused by high consumption of glucose. DM compiles groups of metabolic...
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Inhibition of Liver Cancer Cell Viability by Triazole through Up-regulation of p38 Phosphorylation and Targeting the Activation of p-ERK1/2 and Akt Protein Expression
AbstractThe present study was aimed to explore the effect of triazole on growth and viability of liver cancer cells. Cell growth was examined using...
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Synthesis of Morpholine Linked Indole-1,2,3-triazole Hybrids as In Vitro Tubulin Polymerization Inhibiting Agents
AbstractObjective: Synthesis of some new some new morpholine linked indole-1,2,3-triazole hybrids and evaluation of their anti-cancer activity. ...
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Green preparation of new pyrimidine triazole derivatives via one-pot multicomponent reactions of guanidine
In this research the goal was to produce novel pyrimidine triazole compounds in high yields using triethylamin as an efficient catalyst. These new...
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Design, 2D Qsar Studies, Molecular Docking, and Synthesis of Novel Triazole Derivatives intended as an Antifungal Agents
AbstractSynthesis of a series of triazole derivatives involved the reaction of pyridine potassium dithiocarbazate and 4-amino-5-(pyridine-4-yl)-4 H -1,...
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Nanobiotic Formulations utilizing Quinoline-based-Triazole functionalized Carbon Quantum Dots via Click Chemistry for Combatting Clinical-Resistant Bacterial Pathogens
Therapeutic options for preventing the trajectory of multi-drug resistance bacterial pathogens could rely on the effort to design a novel technique...
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Triazole Moieties as Potent Drug Molecules: Synthetic Approaches and Application as Promising Candidates as Anticancer Agents (A Review)
AbstractDespite considerable progress in the field of anticancer agent development, there remains a demand for more efficacious and safer drugs. The...
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Diaryl Pyrazoline, 1,3,4-Oxadizole, and 1,2,4-Triazole Pharmacophore Hybridization: Design, Synthesis, HDAC Inhibition, and Caspase 3/7 Activation Studies
AbstractObjective: The study aimed to employ the pharmacophore hybridization technique for the synthesis of novel anticancer compounds by combining...
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In-silico identification and exploration of small molecule coumarin-1,2,3-triazole hybrids as potential EGFR inhibitors for targeting lung cancer
Globally, lung cancer is a significant public health concern due to its role as the leading cause of cancer-related mortalities. The promising target...
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New tetrazolopyrrolidine-1,2,3-triazole analogues as potent anticancer agents: design, synthesis and molecular docking studies
1,2,3-Triazole and tetrazole derivatives bearing pyrrolidines are found to exhibit notable biological activity and have become useful scaffolds in...
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Evaluation of novel chemical compound based on Schiff bases of 4-amino-3-mercapto-5-pyridin-4yl-4H-1,2,4-triazole against Fusarium verticillioides
This study focused on evaluating the antifungal activity of Schiff bases synthesized from triazole molecules. Triazole is a heterocyclic molecule...
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Synthesis, Anticancer Activity and Computational Docking Techniques of Some Novel Derivatives Based on Indole Bearing Oxadiazole–Triazole Moieties
AbstractIn this study, a new series of 1,4-disubstituted-1,2,3-triazole and 2,5-disubstituted oxadiazole tethered indole compounds were synthesized...
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New thymol-derived triazole exhibits promising activity against Trichophyton rubrum
Fungal infections have emerged worldwide, and azole antifungals are widely used to control these infections. However, the emergence of antifungal...
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Synthesis of Some New Coumarin-thiazolidine-2,4-dione-1,2,3-triazole Hybrids as Tubulin Targeting Anti-Lung Cancer Agents
AbstractObjective: Synthesis of some new coumarin-thiazolidine-2,4-dione-1,2,3-triazoles and evaluation of their anti-lung cancer activity. Methods: ...
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Catalyst-free synthesis of highly functionalized triazole hexahydroquinoline carbohydrazide scaffolds via four-component cyclocondensation reaction
A new class of multi-functional triazole hexahydroquinoline carbohydrazide named 2-amino-7,7-dimethyl-5-oxo-4-phenyl-1-(4 H -1,2,4-triazol-3-yl)-1,4,5,6...
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Diversity-oriented synthesis of 1H-1,2,3-triazole tethered pyrazolo[5,1-b]quinazoline hybrids as antimicrobial agents
A straightforward and high yielding synthetic approach is employed to synthesize the novel 1 H -1,2,3-triazole tethered pyrazolo[5,1-b]quinazoline...
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Synthesis of 1,2,3-Triazole Analogs of Linagliptin as Novel DPP-4 Inhibitors: DFT, Molecular Docking Approach
AbstractThe synthesis of some novel 1,2,3-triazole-based linagliptin derivatives from the CuI catalyzed 1,3-dipolar cycloaddition reaction between N -...
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Design, Synthesis and Biological Evaluation of Novel 1H-1,2,4-Triazole Derivatives as Strigolactone Biosynthesis Inhibitors
Strigolactone (SL) biosynthesis inhibitors have shown impressive activity in increasing shoot branching and inhibiting seed germination of the root...
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Synthesis and Docking Studies of Novel Benzimidazole Derivatives Containing Thiophene and Triazole Rings as Potential Urease Inhibitors
AbstractA new series of 5,6-dichloro-benzimidazoles containing thiophene ring derivatives of thiosemicarbazides and triazoles were designed,...
