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Deciphering the role of RNA structure in translation efficiency
BackgroundRNA secondary structure has broad impact on the fate of RNA metabolism. The reduced stability of secondary structures near the...
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TGF-β1 facilitates gallbladder carcinoma metastasis by regulating FOXA1 translation efficiency through m6A modification
TGF-β1 plays a pivotal role in the metastatic cascade of malignant neoplasms. N6-methyladenosine (m 6 A) stands as one of the most abundant...
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Engineering disease-resistant plants with alternative translation efficiency by switching uORF types through CRISPR
Engineering disease-resistant plants can be a powerful solution to the issue of food security. However, it requires addressing two fundamental...
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25KDa branched polyethylenimine increases interferon-γ production in natural killer cells via improving translation efficiency
BackgroundEx vivo cultivation is a promising strategy for increasing the number of NK cells and enhancing their antitumor activity prior to clinical...
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Host adaptive mutations in the 2009 H1N1 pandemic influenza A virus PA gene regulate translation efficiency of viral mRNAs via GRSF1
Avian species are the major natural reservoir from which pandemic influenza A viruses can be introduced to humans. Avian influenza A virus genes,...
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The effect of the nucleotides immediately upstream of the AUG start codon on the efficiency of translation initiation in sperm cells
It is widely known that an optimal nucleotide sequence context immediately upstream of the AUG start codon greatly improves the efficiency of...
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Enhancing translation efficiency and exploring constraints in high-level 4-hydroxyvaleric acid production from levulinic acid in Escherichia coli
4-Hydroxyvaleric acid (4-HV) holds promise as a sustainable monomer for biodegradable polyesters and liquid transportation fuels. This study achieved...
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METTL3 drives NSCLC metastasis by enhancing CYP19A1 translation and oestrogen synthesis
BackgroundMETTL3 plays a significant role as a catalytic enzyme in mediating N6-methyladenosine (m 6 A) modification, and its importance in tumour...
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m6A modification mediates SLC3A2/SLC7A5 translation in 3-methylcholanthrene-induced uroepithelial transformation
3-Methylcholanthracene (3-MC) is one of the most carcinogenic polycyclic aromatic hydrocarbons (PAHs). Long-term exposure to PAHs has been thought of...
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Transcriptional programming of translation by BCL6 controls skeletal muscle proteostasis
Skeletal muscle is dynamically controlled by the balance of protein synthesis and degradation. Here we discover an unexpected function for the...
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Diversity and Evolution of Mitochondrial Translation Apparatus
AbstractThe evolution of mitochondria has proceeded independently in different eukaryotic lines, which is reflected in the diversity of mitochondrial...
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FTH1 overexpression using a dCasRx translation enhancement system protects the kidney from calcium oxalate crystal-induced injury
The engineered clustered regularly interspaced short palindromic repeats (CRISPR)–CRISPR-associated protein (Cas) system is currently widely applied...
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Molecular Mechanisms to Optimize Gene Translation Elongation Differ Significantly in Bacteria with and without Nonribosomal Peptides
AbstractNonribosomal peptides play an important role in the vital activity of bacteria and have an extremely broad field of biological activity. In...
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The molecular basis of translation initiation and its regulation in eukaryotes
The regulation of gene expression is fundamental for life. Whereas the role of transcriptional regulation of gene expression has been studied for...
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Plant HEM1 specifies a condensation domain to control immune gene translation
Translational reprogramming is a fundamental layer of immune regulation, but how such a global regulatory mechanism operates remains largely unknown....
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Proline codon pair selection determines ribosome pausing strength and translation efficiency in bacteria
The speed of mRNA translation depends in part on the amino acid to be incorporated into the nascent chain. Peptide bond formation is especially slow...
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Branched chemically modified poly(A) tails enhance the translation capacity of mRNA
Although messenger RNA (mRNA) has proved effective as a vaccine, its potential as a general therapeutic modality is limited by its instability and...
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Folate regulates RNA m5C modification and translation in neural stem cells
BackgroundFolate is an essential B-group vitamin and a key methyl donor with important biological functions including DNA methylation regulation....
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LINC02870 facilitates SNAIL translation to promote hepatocellular carcinoma progression
Exploring the roles of long noncoding RNAs (lncRNAs) in tumorigenesis and metastasis could contribute to the recognition of novel diagnostic and...
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Translation in Mitochondrial Ribosomes
Mitochondrial protein synthesis is essential for the life of aerobic eukaryotes. Without it, oxidative phosphorylation cannot be coupled. Evolution...