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Dynamic epistasis analysis reveals how chromatin remodeling regulates transcriptional bursting
Transcriptional bursting has been linked to the stochastic positioning of nucleosomes. However, how bursting is regulated by the remodeling of...
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Mechanistic analysis of enhancer sequences in the estrogen receptor transcriptional program
Estrogen Receptor α (ERα) is a major lineage determining transcription factor (TF) in mammary gland development. Dysregulation of ERα-mediated...
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Deep generative modeling of transcriptional dynamics for RNA velocity analysis in single cells
RNA velocity has been rapidly adopted to guide interpretation of transcriptional dynamics in snapshot single-cell data; however, current approaches...
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transcAnalysis: A Snakemake Pipeline for Differential Expression and Post-transcriptional Modification Analysis
The transcAnalysis pipeline is a comprehensive tool that allows the analysis of transcriptome data. The pipeline allows for analysis of differential...
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Comparative and integrative single cell analysis reveals new insights into the transcriptional immaturity of stem cell-derived β cells
Diabetes cell replacement therapy has the potential to be transformed by human pluripotent stem cell-derived β cells (SC-β cells). However, the...
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Post-Transcriptional Gene Regulation
This volume presents the most recent advances in techniques for studying the post-transcriptional regulation of gene expression (PTR). With sections...
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Massively integrated coexpression analysis reveals transcriptional regulation, evolution and cellular implications of the yeast noncanonical translatome
BackgroundRecent studies uncovered pervasive transcription and translation of thousands of noncanonical open reading frames (nORFs) outside of...
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Pan-cancer analysis of mRNA stability for decoding tumour post-transcriptional programs
Measuring mRNA decay in tumours is a prohibitive challenge, limiting our ability to map the post-transcriptional programs of cancer. Here, using a...
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Single-cell RNA-sequencing data analysis reveals a highly correlated triphasic transcriptional response to SARS-CoV-2 infection
Single-cell RNA sequencing (scRNA-seq) is currently one of the most powerful techniques available to study the transcriptional response of thousands...
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Transcriptional Regulation of Capsaicin Biosynthesis
The total amount of RNA transcribed in a tissue at specific point of time under constant environmental condition is referred to as transcriptome....
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Transcriptional Regulation of Gene Expression in Plant Abiotic Stress Response
This chapter offers an in-depth analysis of gene expression regulation through transcriptional mechanisms, with a particular focus on the significant...
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Joint analysis of mutational and transcriptional landscapes in human cancer reveals key perturbations during cancer evolution
BackgroundTumors are able to acquire new capabilities, including traits such as drug resistance and metastasis that are associated with unfavorable...
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A robust ultrasensitive transcriptional switch in noisy cellular environments
Ultrasensitive transcriptional switches enable sharp transitions between transcriptional on and off states and are essential for cells to respond to...
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Transcriptional and Post-transcriptional Regulation of Tuberization in Potato (Solanum tuberosum L.)
The transition from juvenile to adult stage is an important switch in the plant’s life cycle. Potato is a temperate staple food crop consumed...
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Single-cell transcriptomic analysis reveals transcriptional and cell subpopulation differences between human and pig immune cells
BackgroundThe pig is a promising donor candidate for xenotransplantation. Understanding the differences between human and swine immune systems is...
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CRISPR-Based Transcriptional Activation in Drosophila
Overexpression is one of the classical approaches to study pleiotropic functions of genes of interest. To achieve overexpression, we often increase...
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Transcriptional and post-transcriptional control of autophagy and adipogenesis by YBX1
Obesity is strongly associated with metabolic diseases, which have become a global health problem. Exploring the underlying mechanism of adipogenesis...
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Lipid accumulation and SNF1 transcriptional analysis of Mucor circinelloides on xylose under nitrogen limitation
Sucrose non-fermenting 1 (SNF1) plays a crucial role in utilizing non-glucose carbon sources and regulating lipid metabolism. However, the mechanism...
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Epigenetic and Transcriptional Dynamics of Notch Program in Intestinal Differentiation
The equilibrium between stem cell self-renewal and differentiation followed by proper lineage specification of progenitor cells is considered...
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Transcriptional analysis of the dimorphic fungus Umbilicaria muehlenbergii reveals the molecular mechanism of phenotypic transition
The lichen-forming fungus Umbilicaria muehlenbergii undergoes a phenotypic transition from a yeast-like to a pseudohyphal form. However, it remains...
