Search
Search Results
-
ZFP462 safeguards neural lineage specification by targeting G9A/GLP-mediated heterochromatin to silence enhancers
ZNF462 haploinsufficiency is linked to Weiss–Kruszka syndrome, a genetic disorder characterized by neurodevelopmental defects, including autism....
-
Transcriptional regulation of tomato fruit ripening
An intrinsic and genetically determined ripening program of tomato fruits often depends upon the appropriate activation of tissue- and stage-specific...
-
Large-scale manipulation of promoter DNA methylation reveals context-specific transcriptional responses and stability
BackgroundCytosine DNA methylation is widely described as a transcriptional repressive mark with the capacity to silence promoters. Epigenome...
-
Keep quiet: the HUSH complex in transcriptional silencing and disease
The human silencing hub (HUSH) complex is an epigenetic repressor complex whose role has emerged as an important guardian of genome integrity. It...
-
Shaking up the silence: consequences of HMGN1 antagonizing PRC2 in the Down syndrome brain
Intellectual disability is a well-known hallmark of Down Syndrome (DS) that results from the triplication of the critical region of human chromosome...
-
The transcriptional response in mosquitoes distinguishes between fungi and bacteria but not Gram types
Mosquitoes are prolific vectors of human pathogens, therefore a clear and accurate understanding of the organization of their antimicrobial defenses...
-
Functions of HP1 proteins in transcriptional regulation
In eukaryotes, DNA is packaged into chromatin, which presents significant barriers to transcription. Non-histone chromatin proteins such as the...
-
High-throughput techniques enable advances in the roles of DNA and RNA secondary structures in transcriptional and post-transcriptional gene regulation
The most stable structure of DNA is the canonical right-handed double helix termed B DNA. However, certain environments and sequence motifs favor...
-
RUVBL1-modulated chromatin remodeling alters the transcriptional activity of oncogenic CTNNB1 in uveal melanoma
Recent years have witnessed an increasing research interest in the therapeutic value of aberrant chromatin regulatory processes in carcinogenesis....
-
Post-transcriptional regulation of myogenic transcription factors during muscle development and pathogenesis
The transcriptional regulation of skeletal muscle (SKM) development (myogenesis) has been documented for over 3 decades and served as a paradigm for...
-
Cooperative regulation of Zhx1 and hnRNPA1 drives the cardiac progenitor-specific transcriptional activation during cardiomyocyte differentiation
The zinc finger proteins (ZNFs) mediated transcriptional regulation is critical for cell fate transition. However, it is still unclear how the ZNFs...
-
Transcriptional control of energy metabolism by nuclear receptors
Transcriptional regulation of catabolic pathways is a central mechanism by which cells respond to physiological cues to generate the energy required...
-
LINC00313 facilitates osteosarcoma carcinogenesis and metastasis through enhancing EZH2 mRNA stability and EZH2-mediated silence of PTEN expression
BackgroundOsteosarcoma is one of the five leading causes of cancer death among all pediatric malignancies. Recent advances in non-coding RNAs...
-
CISD2 transcriptional activated by transcription factor E2F7 promotes the malignant progression of cervical cancer
Cervical cancer (CC) is the second most common type of cancer in women, and presents a serious threat to public health. We aimed to investigate the...
-
WFDC3 inhibits tumor metastasis by promoting the ERβ-mediated transcriptional repression of TGFBR1 in colorectal cancer
Estrogen plays a protective role in colorectal cancer (CRC) and primarily functions through estrogen receptor β (ERβ). However, clinical strategies...
-
SETDB1-like MET-2 promotes transcriptional silencing and development independently of its H3K9me-associated catalytic activity
Transcriptionally silenced heterochromatin bearing methylation of histone H3 on lysine 9 (H3K9me) is critical for maintaining organismal viability...
-
Transcriptional enhancers and their communication with gene promoters
Transcriptional enhancers play a key role in the initiation and maintenance of gene expression programmes, particularly in metazoa. How these...
-
Comparative transcriptional analysis and identification of hub genes associated with wing differentiation of male in Aphis gossypii
BackgroundAphis gossypii Glover (Hemiptera: Aphididae), a worldwide polyphagous phloem-feeding agricultural pest, has three wing morphs (winged...
-
The two sRNAs OmrA and OmrB indirectly repress transcription from the LEE1 promoter of enteropathogenic Escherichia coli
Enteropathogenic Escherichia coli (EPEC) is a diarrheagenic bacterium that predominantly infects infants in develo** countries. EPEC forms...
-
Exogenous miRNAs induce post-transcriptional gene silencing in plants
Plants seem to take up exogenous RNA that was artificially designed to target specific genes, followed by activation of the RNA interference (RNAi)...
