Search
Search Results
-
Rickettsial DNA and a trans-splicing rRNA group I intron in the unorthodox mitogenome of the fern Haplopteris ensiformis
Plant mitochondrial genomes can be complex owing to highly recombinant structures, lack of gene syntenies, heavy RNA editing and invasion of...
-
Intein-Mediated Protein trans-Splicing of the Recombinant Streptavidin on Magnetosomes
AbstractWhen expressing streptavidin recombinant polypeptide on magnetosomes (called bacterial magnetic nanoparticles, or BMPs), the presence of...
-
Bioinformatic Approaches for the Detection of Fusion Genes and trans-Splicing Products (A Review)
AbstractFusion genes and transcripts can be biological markers as well as the reasons for tumor progression and development. Modern algorithms and...
-
SLIDR and SLOPPR: flexible identification of spliced leader trans-splicing and prediction of eukaryotic operons from RNA-Seq data
BackgroundSpliced leader (SL) trans -splicing replaces the 5′ end of pre-mRNAs with the spliced leader, an exon derived from a specialised non-coding...
-
Dominance is common in mammals and is associated with trans-acting gene expression and alternative splicing
BackgroundDominance and other non-additive genetic effects arise from the interaction between alleles, and historically these phenomena play a major...
-
Evidence of constraint in the 3D genome for trans-splicing in human cells
Fusion transcripts are commonly found in eukaryotes, and many aberrant fusions are associated with severe diseases, including cancer. One class of...
-
In Vivo Histone Labeling Using Ultrafast trans-Splicing Inteins
The development of expressed protein ligation (EPL) widened the scope of questions that could be addressed by mechanistic biochemistry. Protein...
-
Trans-splicing of mRNAs links gene transcription to translational control regulated by mTOR
BackgroundIn phylogenetically diverse organisms, the 5′ ends of a subset of mRNAs are trans -spliced with a spliced leader (SL) RNA. The functions of...
-
Unique features of conventional and nonconventional introns in Euglena gracilis
BackgroundNuclear introns in Euglenida have been understudied. This study aimed to investigate nuclear introns in Euglenida by identifying a large...
-
HIV co-opts a cellular antiviral mechanism, activation of stress kinase PKR by its RNA, to enable splicing of rev/tat mRNA
BackgroundActivation of RNA-dependent stress kinase PKR, especially by viral double-stranded RNA, induces eukaryotic initiation factor 2 α-chain...
-
Editing and modification in trypanosomatids: the resha** of non-coding RNAs
Trypanosomatids include a number of protozoan parasites that infect over 27 million people worldwide. Besides their medical importance, these...
-
Alternative Splicing in Human Biology and Disease
Alternative pre-mRNA splicing allows for the production of multiple mRNAs from an individual gene, which not only expands the protein-coding...
-
Characteristics of duplicated gene expression and DNA methylation regulation in different tissues of allopolyploid Brassica napus
Plant polyploidization increases the complexity of epigenomes and transcriptional regulation, resulting in genome evolution and enhanced...
-
Kinetics study of the natural split Npu DnaE intein in the generation of bispecific IgG antibodies
AbstractRapid and efficient bispecific antibody (BsAb) production for industrial applications is still facing many challenges. We reported a...
-
Aberrant Cyclin D1 splicing in cancer: from molecular mechanism to therapeutic modulation
Cyclin D1 (CCND1), a crucial mediator of cell cycle progression, possesses many mutation types with different mutation frequencies in human cancers....
-
The emerging roles of circular RNA-mediated autophagy in tumorigenesis and cancer progression
Circular RNA (circRNA) is characterized by a specific covalently closed ring structure. The back-splicing of precursor mRNA is the main way of...
-
Identified trans-splicing of YELLOW-FRUITED TOMATO 2 encoding the PHYTOENE SYNTHASE 1 protein alters fruit color by map-based cloning, functional complementation and RACE
Key messageFound a trans -splicing of PHYTOENE SYNTHASE 1 alters tomato fruit color by map-based cloning, functional complementation and RACE...
-
Alternative splicing of mRNA in colorectal cancer: new strategies for tumor diagnosis and treatment
Alternative splicing (AS) is an important event that contributes to posttranscriptional gene regulation. This process leads to several mature...
-
Genion, an accurate tool to detect gene fusion from long transcriptomics reads
BackgroundThe advent of next-generation sequencing technologies empowered a wide variety of transcriptomics studies. A widely studied topic is gene...
