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Evolution of tissue-specific expression of ancestral genes across vertebrates and insects
Regulation of gene expression is arguably the main mechanism underlying the phenotypic diversity of tissues within and between species. Here we...
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Oncogenic Kras induces spatiotemporally specific tissue deformation through converting pulsatile into sustained ERK activation
Tissue regeneration and maintenance rely on coordinated stem cell behaviours. This orchestration can be impaired by oncogenic mutations leading to...
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Inferring mammalian tissue-specific regulatory conservation by predicting tissue-specific differences in open chromatin
BackgroundEvolutionary conservation is an invaluable tool for inferring functional significance in the genome, including regions that are crucial...
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Tissue-specific roles of peroxisomes revealed by expression meta-analysis
Peroxisomes are primarily studied in the brain, kidney, and liver due to the conspicuous tissue-specific pathology of peroxisomal biogenesis...
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Transcriptomic analysis reveals a tissue-specific loss of identity during ageing and cancer
IntroductionUnderstanding changes in cell identity in cancer and ageing is of great importance. In this work, we analyzed how gene expression changes...
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Tissue-specific atlas of trans-models for gene regulation elucidates complex regulation patterns
BackgroundDeciphering gene regulation is essential for understanding the underlying mechanisms of healthy and disease states. While the regulatory...
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Fishing for Developmental Regulatory Regions: Zebrafish Tissue-Specific ATAC-seq
Interactions between transcription factors and regulatory DNA can be described by gene regulatory networks. These networks provide a systems-level...
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Frozen tissue coring and layered histological analysis improves cell type-specific proteogenomic characterization of pancreatic adenocarcinoma
BackgroundOmics characterization of pancreatic adenocarcinoma tissue is complicated by the highly heterogeneous and mixed populations of cells. We...
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In Vivo Tissue-Specific Knockdown of circRNAs Using shRNAs in Drosophila melanogaster
Studying circular RNAs’ function in vivo has been challenging due to the lack of generic tools to manipulate their levels without affecting their...
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A tissue specific-infection mouse model of SARS-CoV-2
Animal models play crucial roles in the rapid development of vaccines/drugs for the prevention and therapy of COVID-19, but current models have some...
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A repertoire of intronic lariat RNAs reveals tissue-specific regulation and target mimicry potential in plants
Lariat RNA is concomitantly produced by excised intron during RNA splicing, which is usually debranched by DBR1, an RNA debranching enzyme. However,...
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Robust and rigorous identification of tissue-specific genes by statistically extending tau score
ObjectivesIn this study, we aimed to identify tissue-specific genes for various human tissues/organs more robustly and rigorously by extending the...
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Early expression onset of tissue-specific effector genes during the specification process in sea urchin embryos
BackgroundIn the course of animal developmental processes, various tissues are differentiated through complex interactions within the gene regulatory...
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Tissue-specific populations from amniotic fluid-derived mesenchymal stem cells manifest variant in vitro and in vivo properties
Amniotic fluid derived mesenchymal stem cells (AFMSCs), shed along the fetal development, exhibit superior multipotency and immunomodulatory...
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H3K18 lactylation marks tissue-specific active enhancers
BackgroundHistone lactylation has been recently described as a novel histone post-translational modification linking cellular metabolism to...
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Tissue-specific RNA Polymerase II promoter-proximal pause release and burst kinetics in a Drosophila embryonic patterning network
BackgroundFormation of tissue-specific transcriptional programs underlies multicellular development, including dorsoventral (DV) patterning of the Drosophila...
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Tissue-specific carbon isotope patterns of amino acids in southern sea otters
The measurement of stable isotope values of individual compounds, such as amino acids (AAs), has become a powerful tool in animal ecology and...
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Overview of Computational and Experimental Methods to Identify Tissue-Specific MicroRNA Targets
As ubiquitous posttranscriptional regulators of gene expression, microRNAs (miRNAs) play key roles in cell physiology and function across taxa. In...
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Tissue-Resident Macrophages Methods and Protocols
This detailed book delves into the diverse techniques and applications to target, isolate, image, phenotype, and analyze tissue-resident and...
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On the distribution and diversity of tissue-specific somatic mutations in honey bee (Apis mellifera) drones
Somatic mutations originate from both exogenous (e.g. UV radiation, chemical agents) and endogenous (e.g., DNA replication, defective DNA repair)...
