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Engineering Tissue Inhibitors of Metalloproteinases Using Yeast Surface Display
Yeast surface display (YSD) has been extensively used for protein design, engineering, and directed evolution in the past two decades. Here, we...
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GnT-V-mediated aberrant N-glycosylation of TIMP-1 promotes diabetic retinopathy progression
BackgroundVascular endothelial growth factor (VEGF) signaling pathway plays an important role in the progression of diabetic retinopathy (DR). The...
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Relationship between Trace Elements and Matrix Metalloproteinases 2 and 9 and their Tissue Inhibitors in Medullary Thyroid Carcinoma
Medullary Thyroid Carcinoma (MTC) constitutes around 5% of all thyroid cancers. Trace elements assessment has emerged as a useful strategy in the...
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Serum matrix metalloproteinase-7: a potential biomarker in patients with Lynch Syndrome
Background and aimsThe expression of tissue and serum matrix metalloproteinase-7 (MMP-7) was shown to be elevated both in colon cancer and dysplastic...
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Identification of TIMPs signatures in Randall plaque from single-cell RNA sequencing (scRNA-Seq) analysis
BackgroundTissue inhibitors of metalloproteinases (TIMPs) are essential for controlling the dynamics of the extracellular matrix. Although their role...
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Time-course and muscle-specific gene expression of matrix metalloproteinases and inflammatory cytokines in response to acute treadmill exercise in rats
BackgroundThe extracellular matrix (ECM) of skeletal muscle plays a pivotal role in tissue repair and growth, and its remodeling tightly regulated by...
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Guggulsterone protects against cigarette smoke-induced COPD linked lung inflammation
Recently, we have shown that guggulsterone is the principal constituent responsible for protective effects of Commiphora wightii against...
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Matrix metalloproteinase contribution in management of cancer proliferation, metastasis and drug targeting
Matrix metalloproteinases (MMPs) or matrixins, are members of a zinc-dependent endopeptidase family. They cause remodeling of the extracellular...
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Schwann cells promote prevascularization and osteogenesis of tissue-engineered bone via bone marrow mesenchymal stem cell-derived endothelial cells
BackgroundTissue-engineered bone grafts (TEBGs) that undergo vascularization and neurotization evolve into functioning bone tissue. Previously, we...
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The Role of Metalloproteinases in the Development of Ischemia-Induced Pathologies of the Blood–Brain Barrier
AbstractThe blood–brain barrier (BBB) maintains brain homeostasis by regulating the transport of nutrients and macromolecules from the bloodstream....
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Targeting Dysregulation of Metalloproteinase Activity in Osteoarthritis
Metalloproteinases were first identified as collagen cleaving enzymes and are now appreciated to play important roles in a wide variety of biological...
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The MMP-9 promoter genetic variant rs3918242, mRNA and protein expression in advanced carotid plaque tissue
BackgroundThe MMP-9 is a known player in atherosclerosis, yet associations of the MMP-9 -1562 C/T variant (rs3918242) with various atherosclerotic...
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Quantitative Mass Spectrometry-Based Secretome Analysis as a Tool to Investigate Metalloprotease and TIMP Activity
Cell surface proteolysis controls numerous biological processes including cell–cell attachment and the communication between cells. The...
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mRNA expression profiles of proteolytic genes during the process of ovulation in ovarian follicles of sturgeons
In sturgeon aquaculture, oocyte maturation and ovulation are induced by the administration of hormones such as luteinizing hormone–releasing hormone...
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RECK and TIMP-2 mediate inhibition of MMP-2 and MMP-9 by Annona muricata
Up-regulation of MMP-2 and MMP-9 plays a significant role in promoting cancer progression by degrading the components of the extracellular matrix,...
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New insights into fibrosis from the ECM degradation perspective: the macrophage-MMP-ECM interaction
Fibrosis is a pathological feature of a variety of chronic inflammatory diseases that can affect almost all organs, which can cause severe...
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Polymorphisms and gene expression of metalloproteinases and their inhibitors associated with cerebral ischemic stroke in young patients with sickle cell anemia
BackgroundSickle cell anemia (SCA) is a genetic disease with great clinical heterogeneity and few viable strategies for treatment; hydroxyurea (HU)...
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Impact of Co-chaperones and Posttranslational Modifications Toward Hsp90 Drug Sensitivity
Posttranslational modifications (PTMs) regulate myriad cellular processes by modulating protein function and protein-protein interaction. Heat shock...
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Anti-inflammatory and anti-oxidant activities of mesenchymal stem cells in chemically induced arthritic rats
BackgroundMesenchymal stem cells (MSCs) have been extensively used as cell-based treatments for decades due to their anti-inflammatory,...
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Features of Matrix Metalloproteinases MMP2, MMP3, and MMP9 of Regulatory-Region Polymorphism in Patients with Uterine Fibroids
AbstractDysregulation of the extracellular matrix components synthesis contributes to the formation and growth of uterine fibroids. Changes of...