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Lysine 2-hydroxyisobutyrylation levels determined adipogenesis and fat accumulation in adipose tissue in pigs
BackgroundExcessive backfat deposition lowering carcass grade is a major concern in the pig industry, especially in most breeds of obese type pigs....
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PDGFRβ + cell HIF2α is dispensable for white adipose tissue metabolic remodeling and hepatic lipid accumulation in obese mice
BackgroundObesity is associated with extensive white adipose tissue (WAT) expansion and remodeling. Healthy WAT expansion contributes to the...
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Osmolyte Accumulation
Considerable caution is required in extrapolating osmolyte accumulation results to understanding plant growth under field water deficits. Experiments...
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Tissue Accumulation, Cytotoxicity, Oxidative Stress, and Immunotoxicity in African Catfish, Clarias gariepinus Exposed to Sublethal Concentrations of Hexavalent Chromium
Hexavalent chromium (Cr 6+ ) is one of the stable oxidation states of chromium that has been reported to elicit various toxic effects in aquatic...
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A new perspective on the function of Tissue Non-Specific Alkaline Phosphatase: from bone mineralization to intra-cellular lipid accumulation
Tissue-nonspecific alkaline phosphatase (TNAP) is one of four isozymes, which include germ cell, placental and intestinal alkaline phosphatases. The...
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Soft Tissue Reconstruction
Autologous fat transplantation has revolutionized soft tissue reconstruction, but conventional methods remain unpredictable as graft resorption rates...
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Gamma ray–induced tissue responses and improved secondary metabolites accumulation in Catharanthus roseus
AbstractThe present study investigated the impact of gamma ray irradiation on callus biomass growth and the yield of vincristine and vinblastine of...
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ACSM5 inhibits ligamentum flavum hypertrophy by regulating lipid accumulation mediated by FABP4/PPAR signaling pathway
BackgroundLigamentum flavum (LF) hypertrophy is the main cause of lumbar spinal canal stenosis (LSCS). Previous studies have shown that LF...
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Iron accumulation drives fibrosis, senescence and the senescence-associated secretory phenotype
Fibrogenesis is part of a normal protective response to tissue injury that can become irreversible and progressive, leading to fatal diseases....
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Sublethal Concentrations of Cadmium and Lead: Effects on Hemato-Biochemical Parameters and Tissue Accumulation in Wallagu attu
The exposure of fish to heavy metals can significantly impact physiological processes and potentially lead to adverse health effects. This study...
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Manganese Accumulation and Tissue-level Distribution in the Australian Hyperaccumulator Gossia Bidwillii (Myrtaceae)
The manganese (Mn) hyperaccumulator Gossia bidwillii is a tree species native to subtropical eastern Australia where it occurs on Mn-rich soils....
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LPS-induced monocarboxylate transporter-1 inhibition facilitates lactate accumulation triggering epithelial-mesenchymal transformation and pulmonary fibrosis
The epithelial-mesenchymal transformation (EMT) process of alveolar epithelial cells is recognized as involved in the development of pulmonary...
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Pancreastatin inhibitor PSTi8 ameliorates insulin resistance by decreasing fat accumulation and oxidative stress in high-fat diet-fed mice
Abnormal fat accumulation, enhanced free fatty acids (FFA) release, and their metabolites cause insulin resistance (IR) in major glucose-lipid...
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A commentary on studies of brain iron accumulation during ageing
Brain iron content is widely reported to increase during “ageing”, across multiple species from nematodes, rodents (mice and rats) and humans. Given...
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Reduction of spermine synthase enhances autophagy to suppress Tau accumulation
Precise polyamine metabolism regulation is vital for cells and organisms. Mutations in spermine synthase (SMS) cause Snyder–Robinson intellectual...
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Whole-Mount Imaging of Adipose Tissue Macrophages
The adipose tissue comprises highly heterogeneous macrophage populations, which play critical roles in the regulation of adipose tissue function and...
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Tissue Regeneration Processing and Mimicking
Tissue regenerationTissue regeneration has been one of the comprehensive topics that underlie tissue engineeringTissue engineering and has been...
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Deubiquitinase USP1 enhances CCAAT/enhancer-binding protein beta (C/EBPβ) stability and accelerates adipogenesis and lipid accumulation
Dysregulation of the ubiquitin-proteasome system has been implicated in the pathogenesis of several metabolic disorders, including obesity, diabetes,...
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Evidence for an accumulation of mineral oil saturated hydrocarbons (MOSH) in human tissues: a re-evaluation of biopsy and autopsy data
Consumers are exposed to mineral oil hydrocarbons (MOH) e.g. through foodstuffs and cosmetics. Upon ingestion, MOH follow the absorption pathway of...
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Strategies for Constructing Tissue-Engineered Fat for Soft Tissue Regeneration
Background:Repairing soft tissue defects caused by inflammation, tumors, and trauma remains a major challenge for surgeons. Adipose tissue...
