Search
Search Results
-
-
Exploring COVID-19 Pandemic Disparities with Transcriptomic Meta-analysis from the Perspective of Personalized Medicine
Infection with SARS-CoV2, which is responsible for COVID-19, can lead to differences in disease development, severity and mortality rates depending...
-
Human ACE2 Ectodomain Binding with 78 Drugs
Shaw et al. (2020) selected 5152 drug molecules from the FDA drug library and found that during 2...
-
Endophytes: a uniquely tailored source of potential antibiotic adjuvants
Multidrug microbial resistance is risking an annual loss of more than 10 million people’ lives by 2050. Solutions include the rational use of...
-
Alternative Therapy Options for Pathogenic Yeasts: Targeting Virulence Factors with Non-conventional Antifungals
Pathogenic yeasts constitute a significant part of the global fungal disease burden, particularly in immunocompromised individuals. Currently...
-
Prevalence and Antibiotic Resistance Patterns of Methicillin-Resistant Staphylococcus aureus (MRSA) in a Hospital Setting: A Retrospective Study from 2018 to 2022
Methicillin-resistant Staphylococcus aureus (MRSA) is a highly infectious pathogen that poses a serious threat to human life and health. This study...
-
Synthesis of Some Benzimidazole-Thiophene Hybrids as Potential Urease and Lipase Inhibitors
AbstractIn this study, some benzimidazole-thiophene hybrid compounds containing isatin and salicyl moieties were synthesized and investigated for...
-
Investigation of the Chemical Composition, Antimicrobial, and Antioxidant Activity of Endemic Onosma halophila Boiss. & Heldr.
The Onosma halophila Boiss. & Heldr. belongs to the Boraginaceae family and it is endemic species from Turkey that distributes in Salt Lake (Tuz...
-
Emerging Non-Traditional Approaches to Combat Antibiotic Resistance
An increasing number of bacterial pathogens are acquiring resistance to the commonly used antibiotics. This has spurred a global threat leading to a...
-
The association of the platelet/high-density lipoprotein cholesterol ratio with self-reported stroke and cardiovascular mortality: a population-based observational study
BackgroundPrevious studies have shown that the relationship between high-density lipoprotein cholesterol (HDL-C) and stroke is controversial, and the...
-
Association of ACE gene polymorphisms with in-stent restenosis by stent type (biomime, supraflex, xience)
IntroductionAngiotensin Converting Enzyme or ACE is an exo-peptidase that causes the conversion of angiotensin I to angiotensin II, vasoconstriction,...
-
The Influence of Celery (Apium graveolens) Juice on Hypertension
Hypertension remains an unsolved public health and socioeconomic problem (Deussen A, Kopaliani I, Curr Opin Nephrol Hypertens 32:111–117, 2023)....
-
Identification of potential salivary biomarkers for Sjögren’s syndrome with an untargeted metabolomic approach
IntroductionDespite the rise of metabolomics over the past years, and particularly salivary metabolomics, little research on Sjögren’s syndrome (SS)...
-
Investigation of Platelet Aggregation in Atherosclerosis
Platelet activation and aggregation is implicated in all stages of inflammation-related atherosclerosis from the initial steps of endothelial...
-
Therapeutic peptides for coronary artery diseases: in silico methods and current perspectives
Many drug formulations containing small active molecules are used for the treatment of coronary artery disease, which affects a significant part of...
-
Integrated bioinformatics analysis of retinal ischemia/reperfusion injury in rats with potential key genes
The tissue damage caused by transient ischemic injury is an essential component of the pathogenesis of retinal ischemia, which mainly hinges on the...
-
Mining a stroke knowledge graph from literature
BackgroundStroke has an acute onset and a high mortality rate, making it one of the most fatal diseases worldwide. Its underlying biology and...
-
Drug repurposing strategy part 1: from approved drugs to agri-bactericides leads
Phytopathogenic bacteria are a major cause of crop mortality and yield reduction, especially in field cultivation. The lack of effective chemistry...
-
Autophagy and autophagy-related pathways in cancer
Maintenance of protein homeostasis and organelle integrity and function is critical for cellular homeostasis and cell viability. Autophagy is the...
-
Integrating cell morphology with gene expression and chemical structure to aid mitochondrial toxicity detection
Mitochondrial toxicity is an important safety endpoint in drug discovery. Models based solely on chemical structure for predicting mitochondrial...
