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Thymosin β4 dynamics during chicken enteroid development
The sheared avian intestinal villus-crypts exhibit high tendency to self-repair and develop enteroids in culture. Presuming that this transition...
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Effects of thymosin β4-derived peptides on migration and invasion of ovarian cancer cells
BackgroundThymosin β4 (Tβ4) is a highly conserved actin binding protein associated with the metastatic potential of tumor cells by stimulating cell...
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Thymosin beta-4 improves endothelial function and reparative potency of diabetic endothelial cells differentiated from patient induced pluripotent stem cells
BackgroundPrior studies show that signature phenotypes of diabetic human induced pluripotent stem cells derived endothelial cells (dia-hiPSC-ECs) are...
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Solid-State, Thermal Synthesis of Peptide/Protein–Boron Cluster Conjugates
Anionic boron clusters can be used to increase the pharmaceutical properties of the peptides. Here, we describe the method of synthesis of...
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Bound nucleotide can control the dynamic architecture of monomeric actin
Polymerization of actin into cytoskeletal filaments is coupled to its bound adenine nucleotides. The mechanism by which nucleotide modulates actin...
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Direct Cardiac Reprogramming: Current Status and Future Prospects
Advances in cellular reprogramming articulated the path for direct cardiac lineage conversion, bypassing the pluripotent state. Direct cardiac...
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Integrin-linked kinase (ILK): the known vs. the unknown and perspectives
Integrin-linked kinase (ILK) is a multifunctional molecular actor in cell–matrix interactions, cell adhesion, and anchorage-dependent cell growth. It...
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Vascular Functional Recovery and Reparation by Human Endothelial Progenitor Cells
Endogenous vascular reparation is based on mobilization, differentiation, and proliferation of bone marrow–derived and resident proangiogenic...
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Vascular Functional Recovery and Reparation by Human Endothelial Progenitor Cells
Endogenous vascular reparation is based on mobilization, differentiation, and proliferation of bone marrow–derived and resident proangiogenic...
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Therapeutic Potential of Antimicrobial Peptides for Wound Healing
Antimicrobial peptides (AMPs) are small molecular weight proteins with the potential to be applied for drug development. Despite their different...
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Molecular cloning, expression analysis, and the immune-related role of a thymosin β in the goldfish, Carassius auratus
β-Thymosins play critical roles in the regulation of many important physiological processes, but their function in teleost fishes remains poorly...
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Molecular determinants of intrinsic cellular stiffness in health and disease
In recent years, the role of intrinsic biophysical features, especially cellular stiffness, in diverse cellular and disease processes is being...
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Role of Endocardium and Epicardium in Generation of Cardiomyocytes
Endocardial cells form the innermost layer of the heartHeart. EpicardiumEpicardium is the inner layer of the pericardium, the sac of fibrous tissue...
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Actomyosin Complex
Formation of cross-bridges between actin and myosin occurs ubiquitously in eukaryotic cells and mediates muscle contraction, intracellular cargo...
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Harnessing stem cell and lineage reprogramming technology to treat cardiac fibrosis
Cardiac fibrosis is a pathological response characterized by excessive deposition of fibrous connective tissue within the heart. It typically occurs...
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Cardiac Fibroblast and Cardiomyocyte Growth
FibroblastsFibroblast in the heartHeart (cardiac fibroblastsCardiac fibroblasts) aid to maintain structural, mechanical, and electrical functions of...
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Mechanism and role of mitophagy in the development of severe infection
Mitochondria produce adenosine triphosphate and potentially contribute to proinflammatory responses and cell death. Mitophagy, as a conservative...
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Molecular mechanisms of inorganic-phosphate release from the core and barbed end of actin filaments
The release of inorganic phosphate (P i ) from actin filaments constitutes a key step in their regulated turnover, which is fundamental to many...
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Effect of Nanog overexpression on the metastatic potential of a mouse melanoma cell line B16-BL6
Nanog , a marker and regulator of the undifferentiated state in embryonic stem cells were anticipated to be an effective enhancer of cancer...
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Macrophage-driven cardiac inflammation and healing: insights from homeostasis and myocardial infarction
Early and prompt reperfusion therapy has markedly improved the survival rates among patients enduring myocardial infarction (MI). Nonetheless, the...
