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Antiviral activity evaluation and action mechanism of myricetin derivatives containing thioether quinoline moiety
A variety of myricetin derivatives containing thioether quinoline moiety were designed and synthesized. Their structures of title compounds were...
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Design, synthesis and antibacterial activity of novel colistin derivatives with thioether bond-mediated cyclic scaffold
The escalating crisis of multidrug resistance is raising the fear of untreatable Gram-negative infections and killing a substantial number of...
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Rational design, synthesis, and antimicrobial evaluation of novel 1,2,4-trizaole-substituted 1,3,4-oxadiazole derivatives with a dual thioether moiety
In this paper, a series of novel 1,2,4-trizaole-substituted 1,3,4-oxadiazole derivatives with a dual thioether moiety were constructed. The synthetic...
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Diversity-oriented synthesis and antifungal activities of novel pimprinine derivative bearing a 1,3,4-oxadiazole-5-thioether moiety
AbstractBased on the strategy of diversity-oriented synthesis and the structures of natural product pimprinine and streptochlorin, two series of...
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Phylogeny-guided genome mining of roseocin family lantibiotics to generate improved variants of roseocin
Roseocin, the two-peptide lantibiotic from Streptomyces roseosporus , carries extensive intramolecular (methyl)lanthionine bridging in the peptides...
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Facile Preparation of PNA-Peptide Conjugates with a Polar Maleimide-Thioether Linkage
Conjugation of a delivery peptide containing a thiol functionality (e.g., a cysteine residue) with a PNA oligomer displaying a single unprotected...
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Spectroscopic investigation of iron(III) cysteamine dioxygenase in the presence of substrate (analogs): implications for the nature of substrate-bound reaction intermediates
Thiol dioxygenases (TDOs) are a class of metalloenzymes that oxidize various thiol-containing substrates to their corresponding sulfinic acids....
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Alkylation of Galectin-1 with Iodoacetamide and Mass Spectrometric Map** of the Sites of Incorporation
Galectins can display unique sensitivity to oxidative changes that result in significant conformational alterations that prevent carbohydrate...
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Ruthenium-based PACT agents based on bisquinoline chelates: synthesis, photochemistry, and cytotoxicity
The known ruthenium complex [Ru(tpy)(bpy)(Hmte)](PF 6 ) 2 ([ 1 ](PF 6 ) 2 , where tpy = 2,2’:6’,2″-terpyridine, bpy = 2,2’-bipyridine,...
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Reactions of cisplatin and oxaliplatin with penicillin G: implications for drug inactivation and biological activity
Determination of the toxicity of compounds toward cancer cells is a frequent procedure in drug discovery. For metal complexes, which are often...
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Sexually dimorphic effects of methionine sulfoxide reductase A (MsrA) on murine longevity and health span during methionine restriction
Methionine restriction (MR) extends lifespan in various model organisms, and understanding the molecular effectors of MR could expand the repertoire...
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Direct control of store-operated calcium channels by ultrafast laser
Ca 2+ channels are essential to cell birth, life, and death. They can be externally activated by optogenetic tools, but this requires robust...
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Functionalization Strategies for the Development of Nano-Bio-Conjugates in Contemporary Point-of-Care Analytical Devices
Nanobiotechnology has enabled the path for novel diagnostic strategies and nanomedicine to be developed and tested. Potential biomarker detection by...
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Identification and characterisation of antimicrobial compound produced by probiotic Alkalihalobacillus clausii 088AE
In the present study, Alkalihalobacillus clausii 088AE was evaluated for the production of antimicrobial compounds, their characterisation, and...
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Systematic mining of the human microbiome identifies antimicrobial peptides with diverse activity spectra
Human-associated bacteria secrete modified peptides to control host physiology and remodel the microbiota species composition. Here we scanned 2,229...
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Stoffwechsel der Proteine und Aminosäuren
Der Abbau von Nahrungsproteinen und körpereigenen Proteinen speist den Aminosäuren-Pool des Organismus. Überschüssige Aminosäuren können nicht wie...
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Heterologous biosynthesis of myxobacterial lanthipeptides melittapeptins
AbstractThe myxobacteria are an attractive bioresource for bioactive compounds since the large size genome contains many biosynthetic gene clusters...
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How soon do metabolic alterations and oxidative distress precede the reduction of muscle mass and strength in Wistar rats in aging process?
Here we investigate metabolic changes, the antioxidant system and the accumulation of oxidative damage in muscles with different fiber types during...
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Structure and Biosynthesis
Owing to antibiotic overuse, the effectiveness of broad-spectrum antibiotics is decreasing, and antibiotic resistance is occurring. Therefore, the...
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Distribution and Metabolism of Antibody-Drug Conjugates
There are hundreds of combinations of linker, payload and antibody format in producing an antibody-drug conjugate (ADC) with a proper safety and...