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Molecular targets and therapeutic strategies for triple-negative breast cancer
Triple-negative breast cancer (TNBC) is known for its heterogeneous complexity and is often difficult to treat. TNBC lacks the expression of major...
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Logic programming-based Minimal Cut Sets reveal consortium-level therapeutic targets for chronic wound infections
Minimal Cut Sets (MCSs) identify sets of reactions which, when removed from a metabolic network, disable certain cellular functions. The traditional...
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CircRNAs in colorectal cancer: potential biomarkers and therapeutic targets
Globally, colorectal cancer (CRC) is the third most prevalent cancer and the second leading cause of cancer-related deaths. Circular RNAs (circRNAs)...
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Mechanisms of Bleomycin-induced Lung Fibrosis: A Review of Therapeutic Targets and Approaches
Pulmonary toxicity is a serious side effect of some specific anticancer drugs. Bleomycin is a well-known anticancer drug that triggers severe...
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Mitotic kinases are emerging therapeutic targets against metastatic breast cancer
This review aims to outline mitotic kinase inhibitors’ roles as potential therapeutic targets and assess their suitability as a stand-alone clinical...
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Major regulators of the multi-step metastatic process are potential therapeutic targets for breast cancer management
Metastasis is a multi-step process that leads to the dissemination of tumor cells to new sites and, consequently, to multi-organ neoplasia. Although...
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Identification and validation of key biomarkers and potential therapeutic targets for primary open-angle glaucoma
Primary open-angle glaucoma (POAG) is a prevalent cause of blindness worldwide, resulting in degeneration of retinal ganglion cells and permanent...
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Screens in aging-relevant human ALS-motor neurons identify MAP4Ks as therapeutic targets for the disease
Effective therapeutics is much needed for amyotrophic lateral sclerosis (ALS), an adult-onset neurodegenerative disease mainly affecting motor...
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The Road from AKI to CKD: Molecular Mechanisms and Therapeutic Targets of Ferroptosis
Acute kidney injury (AKI) is a prevalent pathological condition that is characterized by a precipitous decline in renal function. In recent years, a...
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Emerging significance and therapeutic targets of ferroptosis: a potential avenue for human kidney diseases
Kidney diseases remain one of the leading causes of human death and have placed a heavy burden on the medical system. Regulated cell death...
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Molecular pathways and therapeutic targets linked to triple-negative breast cancer (TNBC)
Cancer is a group of diseases characterized by uncontrolled cellular growth, abnormal morphology, and altered proliferation. Cancerous cells lose...
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MicroRNAs as prospective biomarkers, therapeutic targets and pharmaceuticals in neuroblastoma
Neuroblastomas, the most prevalent malignant solid neoplasms of childhood, originate from progenitor cells of the sympathetic nervous system. Their...
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Dysregulation of noncoding RNA in chordoma; implications in identifying potential targets for novel therapeutic approaches
Chordoma is a rare form of bone cancer develops in the spinal cord and skull. Instead of conventional (radio/chemotherapies) and targeted therapies,...
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Super-enhancers and the super-enhancer reader BRD4: tumorigenic factors and therapeutic targets
Transcriptional super-enhancers and the BET bromodomain protein BRD4 are emerging as critical drivers of tumorigenesis and therapeutic targets....
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Inflammatory cell death, PANoptosis, screen identifies host factors in coronavirus innate immune response as therapeutic targets
The COVID-19 pandemic, caused by the β-coronavirus (β-CoV) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), continues to cause...
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Sirtuins in kidney diseases: potential mechanism and therapeutic targets
Sirtuins, which are NAD + -dependent class III histone deacetylases, are involved in various biological processes, including DNA damage repair, immune...
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Cardiac cell senescence: molecular mechanisms, key proteins and therapeutic targets
Cardiac aging, particularly cardiac cell senescence, is a natural process that occurs as we age. Heart function gradually declines in old age,...
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Long Noncoding RNAs as Therapeutic Targets
Long noncoding RNAs (lncRNAs) have emerged as critical regulators of cellular functions including maintenance of cellular homeostasis as well as the...
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The epigenetic regulators EP300/CREBBP represent promising therapeutic targets in MLL-rearranged acute myeloid leukemia
Acute myeloid leukemia (AML) with mixed-lineage leukemia ( MLL ) gene rearrangements (MLL-r) is an aggressive subtype of blood cancer with dismal...
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Progress in Understanding the Role and Therapeutic Targets of Polarized Subtypes of Macrophages in Pulmonary Fibrosis
Pulmonary fibrosis represents the advanced phase of diverse pulmonary ailments, and at present, a definitive cure for these ailments is lacking....
