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Transport and inhibition mechanism for VMAT2-mediated synaptic vesicle loading of monoamines
Monoamine neurotransmitters such as serotonin and dopamine are loaded by vesicular monoamine transporter 2 (VMAT2) into synaptic vesicles for storage...
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Inhibition of VMAT2 by β2-adrenergic agonists, antagonists, and the atypical antipsychotic ziprasidone
Vesicular monoamine transporter 2 (VMAT2) is responsible for packing monoamine neurotransmitters into synaptic vesicles for storage and subsequent...
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Therapeutic Impact of Exosomes on Huntington’s Disease
Huntington’s disease (HD) is a rare neurodegenerative disorder, which significantly disrupts muscle coordination and results in cognitive decline and...
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Secondary metabolite profiling of Sphaerostephanos arbuscula (Wild.) Holttum. chloroform extracts by UHPLC and their biopotency
The chemical diversity among some pteridophytes of Western Ghats, India is reported. Comprehensive study on the chemical constituents is lacking in Sph...
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Deuterium Oxide and Deuteration Effects on Pharmacology
A critical area of pharmacologic research involves the study of how a body processes a drug, including the time course of absorption, distribution,...
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Deuterium Oxide and Deuteration Effects on Health Issues
Deuterium oxide exhibits a variety of biologic activities different from normal water, which makes it possible to gain a deeper insight into the role...
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Reserpine-Induced Depression and Other Neurotoxicity: A Monoaminergic Hypothesis
Depression is a disease that many suffer at some point in their lifetime. Depression can present as an array of symptoms spanning from tiredness to...
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Emerging Stem Cell Therapy and Tissue Engineering-Based Approaches in Neurodegenerative Diseases
Neurodegenerative diseases are a set of disorders with an increasing prevalence caused by the continuous loss of functional neurons. Treatment of...
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Glial Cells in Neuroinflammation in Various Disease States
With current advancements in central nervous system (CNS) research, it is becoming increasingly obvious that glial cells play important roles in both...
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Emerging Stem Cell Therapy and Tissue Engineering-Based Approaches in Neurodegenerative Diseases
Neurodegenerative diseases are a set of disorders with an increasing prevalence caused by the continuous loss of functional neurons. Treatment of...
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Glial Cells in Neuroinflammation in Various Disease States
With current advancements in central nervous system (CNS) research, it is becoming increasingly obvious that glial cells play important roles in both...
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Demethyleneberberine, a potential therapeutic agent in neurodegenerative disorders: a proposed mechanistic insight
IntroductionNeurodegenerative disorders are a diverse variety of diseases that can be distinguished from develo** degeneration of neurons in the...
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Rare genetic disorders in India: Current status, challenges, and CRISPR-based therapy
Rare genetic diseases are a group of life-threatening disorders affecting significant populations worldwide and posing substantial challenges to...
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Zebrafish an experimental model of Huntington’s disease: molecular aspects, therapeutic targets and current challenges
AbstractHuntington disease (HD) is a lethal autosomal dominant neurodegenerative disease whose exact causative mechanism is still unknown. It can...
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Identification of a novel de novo KMT2B variant in a Greek dystonia patient via exome sequencing genotype–phenotype correlations of all published cases
Mutations in Lysine-Specific Histone Methyltransferase 2B gene ( KMT2B ) have been reported to be associated with isolated and complex early-onset...
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Regulated cell death: discovery, features and implications for neurodegenerative diseases
Regulated cell death (RCD) is a ubiquitous process in living organisms that is essential for tissue homeostasis or to restore biological balance...
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Pyroptosis in neurodegenerative diseases: from bench to bedside
The central nervous system regulates all aspects of physiology to some extent. Neurodegenerative diseases (NDDs) lead to the progressive loss and...
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Synuclein Deficiency Decreases the Efficiency of Dopamine Uptake by Synaptic Vesicles
AbstractIn the present study, we analyzed the uptake of radiolabeled dopamine by intact synaptosomes and purified synaptic vesicles isolated from the...
