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Identification of Molecular and Genetic Resistance Mechanisms in a Candida auris Isolate in a Tertiary Care Center in Türkiye
BackgroundCandida auris is a multidrug-resistant pathogen that causes nosocomial outbreaks and high mortality. We conducted this study to...
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Consensus model of a cyanobacterial light-dependent protochlorophyllide oxidoreductase in its pigment-free apo-form and photoactive ternary complex
Photosynthetic organisms employ two different enzymes for the reduction of the C17 = C18 double bond of protochlorophyllide (Pchlide), yielding the...
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Genetic diversity of apple fruit crinkle viroid populations in Japanese persimmons and the infectivity of a predominant sequence variant to tomato plants
Apple fruit crinkle viroid (AFCVd) infects apple, hop, and oriental persimmon plants as natural hosts. The genetic diversity of AFCVd populations in...
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Thomas S. Kuhn: key to a better understanding of the extended evolutionary synthesis
In recent years, some scholars have explicitly questioned the desirability or utility of applying the classical and “old-fashioned” theories of...
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Aging and the programmed death phenomena
Biochemical mechanisms of the programmed death phenomena are considered at levels of unicellular organisms, mitochondria, cells, groups of cells, and...
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A new green revolution or agribusiness as usual? Uncovering alignment issues and potential transition complications in agri-food system transitions
Agri-food system transitions are a considerable challenge requiring stakeholder alignment on what changes need to be made and how. When stakeholders...
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Evidence for dynastic succession among early Celtic elites in Central Europe
The early Iron Age (800 to 450 BCE) in France, Germany and Switzerland, known as the ‘West-Hallstattkreis’, stands out as featuring the earliest...
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Principles for Constructing DNA Barcode Reference Libraries
All DNA barcode methods rely on reference sequences linked to well-curated voucher specimens. Definitions for and locations of DNA barcode reference...
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Nosocomial infection of C. auris in COVID-19 Intensive Care Unit in Türkiye and Phylogenetic Analysis of Isolates
BackgroundThe difficulties in the identification of C. auris and the delays in the implementation of infection control precautions contribute to...
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Star allele search: a pharmacogenetic annotation database and user-friendly search tool of publicly available 1000 Genomes Project biospecimens
Here we describe a new public pharmacogenetic (PGx) annotation database of a large ( n = 3,202) and diverse biospecimen collection of 1000 Genomes...
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Evaluation of fresh, frozen, and lyophilized fecal samples by SPME and derivatization methods using GC×GC-TOFMS
IntroductionFeces is a highly complex matrix containing thousands of metabolites. It also contains live bacteria and enzymes, and does not have a...
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Clostridium perfringens Beta2 toxin forms highly cation-selective channels in lipid bilayers
Clostridium perfringens is a potent producer of a variety of toxins. Well studied from these are five toxins (alpha, Beta (CPB), epsilon, iota and...
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Systemic biochemical changes in pepper (Capsicum annuum L.) against Rhizoctonia solani by kale (Brassica oleracea var. acephala L.) green manure application
BackgroundIn the search for new alternatives to avoid the problems associated with the use of synthetic chemical fungicides in agriculture, the use...
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Evaluation of drought-tolerant endophytic fungus Talaromyces purpureogenus as a bioinoculant for wheat seedlings under normal and drought-stressed circumstances
The present work is aimed to hypothesize that fungal endophytes associated with wheat ( Triticum aestivum L.) plants can play a variety of roles in...
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Expanding the drug discovery space with predicted metabolite–target interactions
Metabolites produced in the human gut are known modulators of host immunity. However, large-scale identification of metabolite–host receptor...
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The Phylogeny and Classification of Predaceous Diving Beetles (Coleoptera: Dytiscidae)
The phylogenetics and higher (family-group) classification of extant members of the beetle family Dytiscidae (Coleoptera), or predaceous diving...
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eSPRESSO: topological clustering of single-cell transcriptomics data to reveal informative genes for spatio–temporal architectures of cells
BackgroundBioinformatics capability to analyze spatio–temporal dynamics of gene expression is essential in understanding animal development. Animal...
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Genetic Structure and Geographical Differentiation of Siberian Larch (Larix sibirica Ledeb.) Populations Based on Genome Genoty** by Sequencing
AbstractThe genetic differentiation of Siberian larch ( Larix sibirica Ledeb.) populations along the latitudinal gradient of climatic conditions was...
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Development and characterization of microsatellite primers for Triops granarius (Branchiopoda: Notostraca) using MiSeq technology
BackgroundNext-generation sequencing technology has allowed for the rapid development of microsatellites, neutral polymorphic markers that can be...