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Insights into taxadiene synthase catalysis and promiscuity facilitated by mutability landscape and molecular dynamics
Main conclusionProtein modeling, carbocation docking, and molecular dynamics along with structure-based mutability landscapes provided insight into...
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Importation of taxadiene synthase into chloroplast improves taxadiene production in tobacco
Main conclusionImportation of taxadiene synthase into chloroplasts is important for the efficient heterologous production of taxadiene.
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Heterologous expression of taxane genes confers resistance to fall armyworm in Nicotiana benthamiana
Key messageTaxadiene synthase ,taxadiene-5α-hydroxylase, and taxane 13α-hydroxylase genes were introduced into Nicotiana benthamiana, and the... 
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Improvements in Taxol Biosynthesis by Metabolic Engineering: Recent Trends
Taxol is one of the major anti-cancer drugs that is derived from plant sources. It was first isolated from Taxus sp. However, due to the limited...
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Computational redesign of taxane-10β-hydroxylase for de novo biosynthesis of a key paclitaxel intermediate
AbstractPaclitaxel (Taxol®) is the most popular anticancer diterpenoid predominantly present in Taxus . The core skeleton of paclitaxel is highly...
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Cloning and homologous characterization of geranylgeranyl pyrophosphate synthase (GGPPS) from Withania somnifera revealed alterations in metabolic flux towards gibberellic acid biosynthesis
Main conclusionOverexpression of a novel geranylgeranyl pyrophosphate synthase gene ( WsGGPPS) in planta resulted in increased levels of gibberellic...
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Plants against cancer: towards green Taxol production through pathway discovery and metabolic engineering
The diversity of plant natural products presents a rich resource for accelerating drug discovery and addressing pressing human health issues....
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Insights into Taxol® biosynthesis by endophytic fungi
AbstractThere have been two hundred reports that endophytic fungi produce Taxol®, but its production yield is often rather low. Although considerable...
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Advances in plastid transformation for metabolic engineering in higher plants
The plastid (chloroplast) genome of higher plants is an appealing target for metabolic engineering via genetic transformation. Although the...
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Manipulation of Key Genes Involved in Biosynthesis of Terpenoid Compounds in Plants
Terpenoids represent the diverse class of plant secondary metabolites exhibiting immense applications in pharmaceutical and other industrial sectors....
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Metabolic Engineering: New Approaches in Pharmaceutical Production
Natural products, natural products-derived, and natural products-inspired compounds represent a major sector of drugs and drug leads. Nature has the...
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Bioengineering Strategy for Production of Plant-Based High-Valued Natural Products
Several medicines have been utilized and prepared for the treatment of various health problems. However, looking beyond the synthetic synthesis of...
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Biotechnology Towards Improvement of Plants for Enhancement of Natural Products
With an increased awareness and affinity towards plant-based natural products for various industrial applications, there is a substantial rise in the...
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Biotechnological Approaches for Medicinal and Aromatic Plant-Based Products
Medicinal and aromatic plants (MAPs) are the reservoirs of numerous life-saving drugs called secondary metabolites including terpenoids, essential...
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Switching cell fate by the actin–auxin oscillator in Taxus: cellular aspects of plant cell fermentation
Key messagePaclitaxel synthesis in Taxus cells correlates with a cell-fate switch that leads to vacuoles of a glossy appearance and vermiform...
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Proteome profiling of methyl jasmonate elicitation of Maytenus ilicifolia in vitro roots reveals insights into sesquiterpene pyridine alkaloids
Maytenus ilicifolia (Celastraceae) is an important medicinal plant widely used in Brazil and a rich source of sesquiterpene pyridine alkaloids (SPAs)...
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Terpenes
Terpenes are secondary metabolites formed by multiplication (polymerization) of a five carbon unit (the isoprene). They are structurally diversified...
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Hitherto Unknown Terpene Synthase Organization in Taxol-Producing Endophytic Bacteria Isolated from Marine Macroalgae
Taxol is a successful anti-cancer drug, which extensively studied in Taxus spp. However, microbial endophytes also reported as taxol producers, and...
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Synthetic Biology of Plants-Derived Medicinal Natural Products
The potential therapeutic role of medicinal plants and natural products attracts scientific attention, and this role is justified due to the presence...
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Production of Plant Natural Products in Heterologous Microbial Species
Plants create a variety of compounds, including secondary metabolites with a variety of forms and bioactive capabilities. These products have a long...