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TargetRNA3: predicting prokaryotic RNA regulatory targets with machine learning
Small regulatory RNAs pervade prokaryotes, with the best-studied family of these non-coding genes corresponding to trans -acting regulators that bind...
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Priority index for critical Covid-19 identifies clinically actionable targets and drugs
While genome-wide studies have identified genomic loci in hosts associated with life-threatening Covid-19 (critical Covid-19), the challenge of...
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Genome Scale Modeling for Novel Drug Targets
System-level metabolic research can make use of computational simulations of genome-scale modeling (GSM), this depict the relationships between genes...
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Molecular targets of histone deacetylase inhibitors in neurodegeneration and neuroprotection
BackgroundNeurodegenerative diseases show various phenotypes of molecular and cellular malfunction including mitochondrial dysfunction and...
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Detection of Specific RNA Targets by Multimerization
AbstractDetection of specific RNA targets via amplification-mediated techniques is widely used in fundamental studies and medicine due to essential...
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FMRP-mediated spatial regulation of physiologic NMD targets in neuronal cells
In non-polarized cells, nonsense-mediated mRNA decay (NMD) generally begins during the translation of newly synthesized mRNAs after the mRNAs are...
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Filamentous Bacteria as Targets to Study Phagocytosis
Filamentous targets are internalized via phagocytic cups that last for several minutes before closing to form a phagosome. This characteristic offers...
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Thermal proteome profiling unveils protein targets of deoxycholic acid in living neuronal cells
Bile acids, synthesized in the liver and modified by the gut microbiota, play vital roles in various physiological processes. The dysregulation of...
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National commitments to Aichi Targets and their implications for monitoring the Kunming-Montreal Global Biodiversity Framework
The Convention on Biological Biodiversity (CBD) exists as a major multilateral environmental agreement to safeguard biodiversity and “live in harmony...
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Identification of lipid-modifying drug targets for autoimmune diseases: insights from drug target mendelian randomization
BackgroundsA growing body of evidence has highlighted the interactions of lipids metabolism and immune regulation. Nevertheless, there is still a...
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Logic programming-based Minimal Cut Sets reveal consortium-level therapeutic targets for chronic wound infections
Minimal Cut Sets (MCSs) identify sets of reactions which, when removed from a metabolic network, disable certain cellular functions. The traditional...
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Exploiting epigenetic targets to overcome taxane resistance in prostate cancer
The development of taxane resistance remains a major challenge for castration resistant prostate cancer (CR-PCa), despite the effectiveness of...
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Computational drug development for membrane protein targets
The application of computational biology in drug development for membrane protein targets has experienced a boost from recent developments in deep...
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Long non-coding RNAs in cancer: multifaceted roles and potential targets for immunotherapy
Cancer remains a major global health concern with high mortality rates mainly due to late diagnosis and poor prognosis. Long non-coding RNAs...
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Molecular targets and therapeutic strategies for triple-negative breast cancer
Triple-negative breast cancer (TNBC) is known for its heterogeneous complexity and is often difficult to treat. TNBC lacks the expression of major...
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Ferroptosis: opening up potential targets for gastric cancer treatment
The fifth most frequent cancer in the world is gastric cancer. It ranks as the fourth most common reason for cancer-related deaths. Even though...
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Systems Approach for Identifying Drug Targets by Computational Approaches
Large datasets are frequently gathered, stored and analysed in the big data age with the goal of guiding biological discoveries and validating...
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Systems Approaches in Identifying Disease-Related Genes and Drug Targets
Target discovery is the first crucial stage in the target drug identification and discovery pipeline. For a better understanding of the underlying...
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Correlations between genetically predicted lipid-lowering drug targets and inflammatory bowel disease
BackgroundMillions of individuals globally suffer from Inflammatory bowel diseases (IBDs). There is a dearth of large population-based investigations...
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Insight into telomere regulation: road to discovery and intervention in plasma drug-protein targets
BackgroundTelomere length is a critical metric linked to aging, health, and disease. Currently, the exploration of target proteins related to...
