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Mammalian target of rapamycin inhibition protects glioma cells from temozolomide-induced cell death
Glioblastoma is an incurable brain tumor with a median survival below two years. Trials investigating targeted therapy with inhibitors of the kinase...
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Hydrogen peroxide modulates the expression of the target of rapamycin (TOR) and cell division in Arabidopsis thaliana
Hydrogen peroxide (H 2 O 2 ) is naturally produced by plant cells during normal development and serves as a messenger that regulates cell metabolism....
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Blazing a trail for the clinical use of rapamycin as a geroprotecTOR
Treatment with rapamycin, an inhibitor of the mechanistic Target Of Rapamycin Complex One (mTORC1) protein kinase, has been repeatedly demonstrated...
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Evaluation of off-label rapamycin use on oral health
Rapamycin (sirolimus) is an FDA approved drug with immune modulating properties that is being prescribed off-label in adults as a preventative...
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Metabolic regulation of cholestatic liver injury by D-2-hydroxyglutarate with the modulation of hepatic microenvironment and the mammalian target of rapamycin signaling
Biliary atresia (BA) is a cholestatic liver disease in neonates with devastating obstructive intrahepatic and extrahepatic biliary ducts. Owing to...
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Rapamycin Inhibits Senescence and Improves Immunomodulatory Function of Mesenchymal Stem Cells Through IL-8 and TGF-β Signaling
Mesenchymal stromal cells (MSCs) grown in high-density monolayers (sheets) are promising vehicles for numerous bioengineering applications. When MSC...
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Rapamycin protects mouse skin from ultraviolet B-induced photodamage by modulating Hspb2-mediated autophagy and apoptosis
BackgroundContinuous exposure to UVB is the main extrinsic cause of skin photodamage, which is associated with oxidative stress, DNA damage,...
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Evaluation of off-label rapamycin use to promote healthspan in 333 adults
Rapamycin (sirolimus) is an FDA-approved drug with immune-modulating and growth-inhibitory properties. Preclinical studies have shown that rapamycin...
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Rapamycin Regulates Lipopolysaccharide-Induced Microglial Phagocytosis In Vitro
AbstractMicroglia phagocytosis plays an important role in the pathogenesis of neurodegeneration. Defects or dysfunction of microglia phagocytosis...
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Screening the possible anti-cancer constituents of Hibiscus rosa-sinensis flower to address mammalian target of rapamycin: an in silico molecular docking, HYDE scoring, dynamic studies, and pharmacokinetic prediction
One of the most common malignancies diagnosed and the leading cause of death for cancer-stricken women globally is breast cancer. The molecular...
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Sexual identity of enterocytes regulates autophagy to determine intestinal health, lifespan and responses to rapamycin
Pharmacological attenuation of mTOR presents a promising route for delay of age-related disease. Here we show that treatment of Drosophila with the...
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Molecular and therapeutic insights of rapamycin: a multi-faceted drug from Streptomyces hygroscopicus
The advancement in pharmaceutical research has led to the discovery and development of new combinatorial life-saving drugs. Rapamycin is a macrolide...
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Rapamycin restores peripheral blood flow in aged mice and in mouse models of atherosclerosis and Alzheimer’s disease
Peripheral artery disease (PAD), defined as reduced blood flow to the lower limbs, is a serious disorder that can lead to loss of function in the...
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Mechanistic target of rapamycin complex 1 orchestrates the interplay between hepatocytes and Kupffer cells to determine the outcome of immune-mediated hepatitis
The cell-cell interaction between hepatocytes and Kupffer cells (KCs) is crucial for maintaining liver homeostasis, and the loss of KCs and...
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Long-lasting geroprotection from brief rapamycin treatment in early adulthood by persistently increased intestinal autophagy
The licensed drug rapamycin has potential to be repurposed for geroprotection. A key challenge is to avoid adverse side effects from continuous...
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Target of rapamycin (TOR) gene is vital for whitefly survival and reproduction
The whitefly Bemisia tabaci (Gennadius) is a devastating polyphagous pest that causes significant losses in several economically important crops...
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Crossregulation of rapamycin and elaiophylin biosynthesis by RapH in Streptomyces rapamycinicus
AbstractRapamycin is an important macrocyclic antibiotic produced by Streptomyces rapamycinicus . In the rapamycin biosynthetic gene cluster (BGC),...
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Loss of TTC17 promotes breast cancer metastasis through RAP1/CDC42 signaling and sensitizes it to rapamycin and paclitaxel
BackgroundBreast cancer (BC) metastasis is the leading cause of poor prognosis and therapeutic failure. However, the mechanisms underlying cancer...
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Target Deconvolution by Limited Proteolysis Coupled to Mass Spectrometry
Limited proteolysis coupled to mass spectrometry (LiP-MS) is a recent proteomics technique that allows structure-based target engagementTarget...
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A cocktail of rapamycin, acarbose, and phenylbutyrate prevents age-related cognitive decline in mice by targeting multiple aging pathways
Aging is a primary risk factor for cognitive impairment and exacerbates multiple biological processes in the brain, including but not limited to...
