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HspBP1 in Complex with the Peptide of the Innate Immunity Protein Tag7 is Able to Lyse Tumor Cells Carrying TNFR1 Receptor
AbstractThe search for new cytotoxic agents capable of lysing tumor cells is an important task in the fight against cancer. Here we have shown that...
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Tag7–Mts1 Complex Activates Chemotaxis of Regulatory T Cells
AbstractOne of the basic features of immune system is the ability to sustain balance between activation and suppression of effector lymphocytes. In...
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Innate Immune Protein Tag7 Stimulates the Appearance of Cytotoxic NK Cells after Incubation with Lymphocytes
AbstractTag7 (PGRP-S) is an innate immune protein that is involved in the antibacterial and antitumor defense and stimulates the maturation of...
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Incubation of Lymphocytes with IL-2 Causes the Appearance of Antitumor T Cells Carrying FC, CD25, and LFA-1 on the Surface
AbstractTo carry out antitumor activity against cells that have lost surface antigens, human lymphocytes must have a certain repertoire of surface...
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HSP70 attenuates neuronal necroptosis through the HSP90α-RIPK3 pathway following neuronal trauma
BackgroundNecroptosis, a newly defined regulatable necrosis with membrane disruption, has been demonstrated to participate in trauma brain injury...
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Droplet-based single-cell joint profiling of histone modifications and transcriptomes
We previously reported Paired-Tag, a combinatorial indexing-based method that can simultaneously map histone modifications and gene expression at...
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Strategies for Improving Biotherapeutic Protein Production in Microbial Cell Factories
Recombinant protein manufacturing is experiencing a global transformation across multiple verticals for achieving sustainable production. Since there...
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Lymphocytes incubated in the presence of IL-2 lose the capacity for chemotaxis but acquire antitumor activity
Naïve non-activated lymphocytes are capable of releasing the chemoattractant complex Tag7–Mts1 and can migrate along the gradient of its...
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Functional analysis of McSnRK1 (SNF1-related protein kinase 1) in regulating Na/K homeostasis in transgenic cultured cells and roots of halophyte Mesembryanthemum crystallinum
Key messageTransgenic callus and roots of ice plant with altered SnRK1 function were established using Agrobacterium -mediated transformation. The...
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Apoptotic tumor cell death under the influence of the cytotoxic complex Tag7–Hsp70 is induced by interaction with the TNFR1 receptor
The results of comparative analysis of interaction between the protein cytotoxic complex Tag 7–Hsp70 and the Tag 7 component of this complex with...
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Selected abstracts from the 26th Conference of the European Cell Death Organization (ECDO): Cell death in disease — from small molecules to translational medicine
Sponsorship: Publication of this supplement was sponsored by the Medical Research Council (MRC). All content was reviewed and approved by the...
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Use of luciferase probes to measure ATP in living cells and animals
ATP, the energy exchange factor that connects anabolism and catabolism, is required for major reactions and processes that occur in living cells,...
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S100A4, a link between metastasis and inflammation
Chronic inflammation is acknowledged to be a hallmark of neoplasia—both in cancer initiation and metastasis progression. Here we summarise data...
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Cell death of L-929 cells induced by cytotoxic complex Tag7-Hsp70 is analogous to the death of the same cells induced by TNF-α
The identification and studying the molecular bases of functioning of new cytotoxic agents finds an important implication in develo** drugs for...
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Affinity chromatography and proteomic screening as an efficient method of detecting new protein targets of S100A4
Affinity chromatography with the subsequent identification of selectively binding proteins can be an efficient way to detect biologically significant...
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High-performance probes for light and electron microscopy
We describe an engineered family of highly antigenic molecules based on GFP-like fluorescent proteins. These molecules contain numerous copies of...
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A general method to improve fluorophores for live-cell and single-molecule microscopy
Specific labeling of biomolecules with bright fluorophores is the keystone of fluorescence microscopy. Genetically encoded self-labeling tag proteins...
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Ectopic expression of a maize calreticulin mitigates calcium deficiency-like disorders in sCAX1-expressing tobacco and tomato
Deregulated expression of an Arabidopsis H + /Ca 2+ antiporter (sCAX1) in agricultural crops increases total calcium (Ca 2+ ) but may result in yield...
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Development of a transgenic tobacco plant for phytoremediation of methylmercury pollution
To develop the potential of plant for phytoremediation of methylmercury pollution, a genetically engineered tobacco plant that coexpresses...
