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The Role of Cholesterol in Membrane Localization of TRPV5 Calcium Channels in Jurkat Human T Cells
AbstractMany ion channels are localized in areas of the plasma membrane enriched in cholesterol and sphingolipids, known as “lipid rafts.” The...
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Whole-Genome Re-sequencing and Transcriptome Reveal Candidate Genes and Pathways Associated with Hybrid Sterility in Hermaphroditic Argopecten Scallops
The interspecific hybrid scallops generated from the hermaphroditic bay scallops ( Argopecten irradians ) and Peruvian scallops ( Argopecten purpuratus )...
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Expression of transient receptor potential vanilloid genes and proteins in diabetic rat heart
Cardiac complications are leading causes of death in diabetic patients. Imbalance of Ca 2+ homeostasis is a hallmark of cardiac dysfunction in...
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The role of TRPV channels in osteoporosis
As the world’s population ages, the treatment of osteoporosis is a major problem to be addressed. The cause of osteoporosis remains unclear. Ca 2+ is...
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Pathophysiological role of Na–Cl cotransporter in kidneys, blood pressure, and metabolism
The Na–Cl cotransporter (NCC) is a well-recognized regulator of ion transportation in the kidneys that facilitates Na + reabsorption in the distal...
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Identification of a Novel Homozygous Missense Mutation in the CLDN16 Gene to Decipher the Ambiguous Clinical Presentation Associated with Autosomal Dominant Hypocalcaemia and Familial Hypomagnesemia with Hypercalciuria and Nephrocalcinosis in an Indian Family
Familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHNNC) is a rare autosomal recessive renal tubulopathy disorder characterized by...
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Structural basis of TRPV5 channel inhibition by econazole revealed by cryo-EM
The transient receptor potential vanilloid 5 (TRPV5) channel is a member of the transient receptor potential (TRP) channel family, which is highly...
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Unraveling the propensity of various genetic disorders and syndromes in the Koraga, an aboriginal tribe from southern India
Koragas, recognized as a particularly vulnerable tribal group (PVTG) by the Government of India, are from coastal Karnataka and Kerala. They are...
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Dietary branched-chain amino acids modulate the dynamics of calcium absorption and reabsorption in protein-restricted pigs
BackgroundVery low-protein (VLP) diets negatively impact calcium (Ca) metabolism and absorption. The objective of this study was to investigate the...
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Emerging concepts on the FGF23 regulation and activity
Fibroblast growth factor 23 (FGF23) discovery has provided new insights into the regulation of Pi and Ca homeostasis. It is secreted by osteoblasts...
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RETRACTED ARTICLE: Transient Receptor Potential (TRP) Family of Channel Proteins
AbstractProteins with a transient receptor potential (TRP) function in the cell membrane as Ca 2+ -permeable nonselective cation channels. TRP...
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The role of serum-glucocorticoid regulated kinase 1 in reproductive viability: implications from prenatal programming and senescence
ObjectiveOrganisms and cellular viability are of paramount importance to living creatures. Disruption of the balance between cell survival and...
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Identification of Prognostic and Immune Characteristics of Two Lung Adenocarcinoma Subtypes Based on TRPV Channel Family Genes
Lung adenocarcinoma (LUAD) is one of the deadliest malignant tumors worldwide. Transient receptor potential vanilloid (TRPV) channels take pivotal...
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Ionocyte Functions and Hormonal Regulation of Ion Exchange in Fish
AbstractThe data on gill ionocyte functions and the effects of hormones on the ion exchange in fish are summarized. The ionocytes found in freshwater...
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Seasonal modulation of the testis transcriptome reveals insights into hibernation and reproductive adaptation in Onychostoma macrolepis
The Onychostoma macrolepis have a unique survival strategy, overwintering in caves and returning to the river for reproduction in summer. The current...
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Integrated mRNA and miRNA analysis reveals the regulatory network of oxidative stress and inflammation in Coilia nasus brains during air exposure and salinity mitigation
BackgroundAir exposure is an inevitable source of stress that leads to significant mortality in Coilia nasus . Our previous research demonstrated...
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Mikronährstoffe
Ein Alpenbewohner mittleren Alters bemerkt eine schmerzlose „Schwellung“ im Bereich des vorderen Halses, die ihm zunehmend Schwierigkeiten beim...
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Map** the expression of transient receptor potential channels across murine placental development
Transient receptor potential (TRP) channels play prominent roles in ion homeostasis by their ability to control cation influx. Mouse placentation is...
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Phosphate, calcium, and vitamin D signaling, transport, and metabolism in the endometria of cyclic ewes
BackgroundRecent evidence suggests important roles for progesterone (P4) and interferon tau in the regulation of calcium, phosphate, and vitamin D...
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Intrinsically disordered regions in TRPV2 mediate protein-protein interactions
Transient receptor potential (TRP) ion channels are gated by diverse intra- and extracellular stimuli leading to cation inflow (Na + , Ca 2+ ) regulating...
