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Overexpression of TRIM44 mediates the NF-κB pathway to promote the progression of ovarian cancer
BackgroundOvarian cancer (OC) is the second most commonly seen cancer in the US, and patients with OC are commonly diagnosed in the advanced stage....
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YTHDF1 promotes the proliferation, migration, and invasion of prostate cancer cells by regulating TRIM44
BackgroundProstate cancer (PCa) is one of the most common malignancies in men. YTHDF1 may play an important role in promoting PCa progression, but...
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The Novel Target of Colorectal Carcinoma: TRIM44 Regulates Cell Migration and Invasion via Activation of CXCR4/NF-κB Signaling
Tripartite motif containing 44 (TRIM44) has been reported to regulate various biological effects in malignant cancers and matrix Metalloproteinases...
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RNA interference-mediated knockdown of tripartite motif containing 44 suppresses cervical cancer growth in vitro and in vivo
BackgroundTripartite motif containing 44 (TRIM44) is an atypical member of the TRIM protein family that has been reported to be aberrantly...
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The potential role of m6A reader YTHDF1 as diagnostic biomarker and the signaling pathways in tumorigenesis and metastasis in pan-cancer
m6A is an important RNA methylation in progression of various human cancers. As the m6A reader protein, YTHDF1 is reported to accelerate m6A-modified...
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Functions of lncRNA DUXAP8 in non-small cell lung cancer
Non-small cell lung cancer (NSCLC) poses a serious threat to public health due to its significant morbidity and mortality rates. The processes of...
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TRIM E3 Ubiquitin Ligases in Rare Genetic Disorders
The TRIM family comprises proteins characterized by the presence of the tripartite motif composed of a RING domain, one or two B-box domains and a...
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The Role of MiRNA in Cancer: Pathogenesis, Diagnosis, and Treatment
Cancer is also determined by the alterations of oncogenes and tumor suppressor genes. These gene expressions can be regulated by microRNAs (miRNA)....
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TRIM36 suppresses cell growth and promotes apoptosis in human esophageal squamous cell carcinoma cells by inhibiting Wnt/β-catenin signaling pathway
Our recent study has shown that TRIM36, a member of tripartite motif-containing (TRIM) family proteins and tumor suppressor and β-catenin may serve...
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The relationship between the network of non-coding RNAs-molecular targets and N6-methyladenosine modification in tumors of urinary system
N6-methyladenosine (m6A) methylation, a prevalent eukaryotic post-transcriptional modification, is involved in multiple biological functions,...
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LncRNA KCNQ1OT1 acts as miR-216b-5p sponge to promote colorectal cancer progression via up-regulating ZNF146
Long non-coding RNAs (lncRNAs) have shown to act as important regulators in cancer biology. The aim of this study was to investigate the role and...
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TRIM65 promotes renal cell carcinoma through ubiquitination and degradation of BTG3
As a typical E3 ligase, TRIM65 (tripartite motif containing 65) is involved in the regulation of antiviral innate immunity and the pathogenesis of...
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TRIMs: selective recruitment at different steps of the NF-κB pathway—determinant of activation or resolution of inflammation
TNF-α-induced NF-κB pathway is an essential component of innate and adaptive immune pathway, and it is tightly regulated by various...
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Unraveling the role of microRNA/isomiR network in multiple primary melanoma pathogenesis
Malignant cutaneous melanoma (CM) is a potentially lethal form of skin cancer whose worldwide incidence has been constantly increasing over the past...
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Insight into the structure, physiological function, and role in cancer of m6A readers—YTH domain-containing proteins
YT521-B homology (YTH) domain-containing proteins (YTHDF1-3, YTHDC1-2) are the most crucial part of N6-methyladenosine (m6A) readers and play a...
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The Origins and Functions of De Novo Genes: Against All Odds?
“De novo” genes evolve from previously non-genic DNA. This strikes many of us as remarkable, because it seems extraordinarily unlikely that random...
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Identification of key regulators associated with colon cancer prognosis and pathogenesis
Colon cancer (CC) is the fourth deadliest cancer in the world. New insights into prognostication might be helpful to define the optimal adjuvant...
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Requirement of splicing factor hnRNP A2B1 for tumorigenesis of melanoma stem cells
BackgroundCancer stem cells play essential roles in tumorigenesis, thus forming an important target for tumor therapy. The hnRNP family proteins are...
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Characterization of the primate TRIM gene family reveals the recent evolution in primates
The tripartite motif ( TRIM ) gene family encodes diverse distinct proteins that play important roles in many biological processes. However, the...
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Functional genomics atlas of synovial fibroblasts defining rheumatoid arthritis heritability
BackgroundGenome-wide association studies have reported more than 100 risk loci for rheumatoid arthritis (RA). These loci are shown to be enriched in...
