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Novel small multidrug resistance protein Tmt endows the Escherichia coli with triphenylmethane dyes bioremediation capability
Dye contamination in printing and dyeing wastewater has long been a major concern due to its serious impact on both the environment and human health....
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TMT quantitative proteomics reveals key proteins relevant to microRNA-1-mediated regulation in osteoarthritis
Osteoarthritis (OA) is the second-commonest arthritis, but pathogenic and regulatory mechanisms underlying OA remain incompletely understood. Here,...
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Proteomic analysis of plasma proteins from patients with cardiac rupture after acute myocardial infarction using TMT-based quantitative proteomics approach
BackgroundCardiac rupture (CR) is a rare but catastrophic mechanical complication of acute myocardial infarction (AMI) that seriously threatens human...
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Optimized sample preparation and data analysis for TMT proteomic analysis of cerebrospinal fluid applied to the identification of Alzheimer’s disease biomarkers
BackgroundCerebrospinal fluid (CSF) is an important biofluid for biomarkers of neurodegenerative diseases such as Alzheimer’s disease (AD). By...
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TMT-based quantitative proteomic analysis of spheroid cells of endometrial cancer possessing cancer stem cell properties
BackgroundCancer stem cells (CSCs) play an important role in endometrial cancer progression and it is potential to isolate CSCs from spheroid cells....
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TMT-based proteomics analysis of the cerebral cortex of TauT knockout rats
BackgroundTaurine serves a variety of nutritional and physiological roles, and it is mostly transported in cells via taurine transporter (TauT). The...
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Biomarkers for subclinical bovine mastitis: a high throughput TMT-based proteomic investigation
Mastitis represents the biggest threat to the health and productivity of dairy cows, leading to substantial economic losses in milk production. It...
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TMT-based quantitative proteomics analysis of the effects of Jiawei Danshen decoction myocardial ischemia-reperfusion injury
BackgroundEvery year, approximately 17 million people worldwide die due to coronary heart disease, with China ranking second in terms of the death...
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TMT proteomic analysis for molecular mechanism of Staphylococcus aureus in response to freezing stress
AbstractThe foodborne pathogen Staphylococcus aureus continues to challenge the food industry due to the pathogenicity and tolerance of the...
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TMT-based quantitative proteomic profiling of human monocyte-derived macrophages and foam cells
BackgroundCardiovascular diseases remain the leading cause of morbidity and mortality worldwide, most of which are caused by atherosclerosis....
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Proteome Based Comparative Investigation of a High Sucrose Sugarcane Mutant in Contrast to the Low Sucrose Mother Variety by Using TMT Quantitative Proteomics
Sugarcane ( Saccharum sp. hybrid) is a significant crop in the world’s economy and fulfills 80% of the world's sugar production. To meet the rising...
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TMT-based proteomic analysis of liquorice root in response to drought stress
BackgroundDrought stress is a serious threat to land use efficiency and crop yields worldwide. Understanding the mechanisms that plants use to...
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TMT-based quantitative proteomics analysis reveals the key proteins related with the differentiation process of goat intramuscular adipocytes
BackgroundIntramuscular adipocytes differentiation is a complex process, which is regulated by various transcription factor, protein factor...
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TMT-Based Quantitative Proteomic Revealed Metabolic Changes of Jasmonic Acid in Regulating the Response of Malus baccata (L.) Borkh. Roots to Low Root-Zone Temperature
Malus baccata (L.) Borkh. is widely used as an apple rootstock in northern China. Previous studies have shown that jasmonic acid (JA) can alleviate...
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TMT-based quantitative proteomic analysis reveals defense mechanism of wheat against the crown rot pathogen Fusarium pseudograminearum
BackgroundFusarium crown rot is major disease in wheat. However, the wheat defense mechanisms against this disease remain poorly understood.
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Response mechanism of ♀ Epinephelus fuscoguttatus × ♂ Epinephelus lanceolatus under low-temperature and waterless stresses using TMT proteomic analysis
♀ Epinephelus fuscoguttatu s × ♂ Epinephelus lanceolatus , a hybrid grouper created from artificial breeding, has been widely developed over the past...
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High-Throughput Profiling of Proteome and Posttranslational Modifications by 16-Plex TMT Labeling and Mass Spectrometry
Mass spectrometry (MS)-based proteomic profiling of whole proteome and protein posttranslational modifications (PTMs) is a powerful technology to...
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Photosynthetic Resilience Under Stress: Unraveling the Role of Phytohormones and Phytometabolites
Photosynthetic organisms grow in diverse habitats and also continuously deal with the fluctuating environmental conditions. The changes in the...
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Tandem Mass Tag-Based Phosphoproteomics in Plants
Mass spectrometry-based proteomics provide a powerful tool for plant research, allowing global detection of steady-state levels of proteins under a...
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Simulating BRAFV600E-MEK-ERK signalling dynamics in response to vertical inhibition treatment strategies
In vertical inhibition treatment strategies, multiple components of an intracellular pathway are simultaneously inhibited. Vertical inhibition of the...
