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TMPRSS2 isoform 1 downregulation by G-quadruplex stabilization induces SARS-CoV-2 replication arrest
BackgroundSARS-CoV-2 infection depends on the host cell factors angiotensin-converting enzyme 2, ACE2, and the transmembrane serinprotease 2,...
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Inhibitor design for TMPRSS2: insights from computational analysis of its backbone hydrogen bonds using a simple descriptor
Transmembrane protease serine 2 (TMPRSS2) is an important drug target due to its role in the infection mechanism of coronaviruses including...
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Peptidomimetic inhibitors of TMPRSS2 block SARS-CoV-2 infection in cell culture
The transmembrane serine protease 2 (TMPRSS2) primes the SARS-CoV-2 Spike (S) protein for host cell entry and represents a promising target for...
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Surface translocation of ACE2 and TMPRSS2 upon TLR4/7/8 activation is required for SARS-CoV-2 infection in circulating monocytes
Infection of human peripheral blood cells by SARS-CoV-2 has been debated because immune cells lack mRNA expression of both angiotensin-converting...
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Profile of chimeric RNAs and TMPRSS2-ERG e2e4 isoform in neuroendocrine prostate cancer
PurposeSpecific gene fusions and their fusion products (chimeric RNA and protein) have served as ideal diagnostic markers and therapeutic targets for...
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Molecular docking analysis reveals the functional inhibitory effect of Genistein and Quercetin on TMPRSS2: SARS-COV-2 cell entry facilitator spike protein
BackgroundThe Transmembrane Serine Protease 2 (TMPRSS2) of human cell plays a significant role in proteolytic cleavage of SARS-Cov-2 coronavirus...
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Withania somnifera phytochemicals possess SARS-CoV-2 RdRp and human TMPRSS2 protein binding potential
AbstractCoronavirus disease-19 (COVID-19) pandemic caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has infected approximately...
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Molecular mechanisms for understanding the association between TMPRSS2 and beta coronaviruses SARS-CoV-2, SARS-CoV and MERS-CoV infection: sco** review
The aim of this sco** review was to identify knowledge gaps and to describe the current state of the research on the association between TMPRSS2...
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Targeting the intestinal TMPRSS2 protease to prevent SARS-CoV-2 entry into enterocytes-prospects and challenges
The transmembrane protease serine 2 (TMPRSS2) is a membrane anchored protease that primarily expressed by epithelial cells of respiratory and...
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Contributions of human ACE2 and TMPRSS2 in determining host–pathogen interaction of COVID-19
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is at present an emerging global public health crisis. Angiotensin converting...
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Binding Assays of Drug and Biological Molecule for Screening Drug Repositioning Candidates as Therapeutic Option against Emerging Infectious Diseases
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative viral pathogen in the coronavirus disease 2019 (COVID-19) pandemic,...
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Assessment of risk conferred by coding and regulatory variations of TMPRSS2 and CD26 in susceptibility to SARS-CoV-2 infection in human
At present, more than 200 countries and territories are directly affected by the coronavirus disease-19 (COVID-19) pandemic. Incidence and case...
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Specific nasopharyngeal Corynebacterium strains serve as gatekeepers against SARS-CoV-2 infection
The SARS-CoV-2 virus is still causing a worldwide problem. The virus settles primarily on the nasal mucosa, and the infection and its course depend...
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Umbelliferone and eriodictyol suppress the cellular entry of SARS-CoV-2
BackgroundArtemisia argyi (A. argyi), also called Chinese mugwort, has been widely used to control pandemic diseases for thousands of years since...
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New AKT-dependent mechanisms of anti-COVID-19 action of high-CBD Cannabis sativa extracts
COVID-19 is caused by the SARS-CoV-2 virus, which enters target cells via interactions with ACE2 and TMPRSS2. Here, we show AKT serine/threonine...
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Epigenetics of SARS-CoV2 (COVID-19)
The study of genetic differences in gene activity without alterations to DNA sequences is referred to as “epigenetics.” The focus of this extremely...
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Synergistic effect of elevated glucose levels with SARS-CoV-2 spike protein induced NOX-dependent ROS production in endothelial cells
Background:Diabetic patients infected with coronavirus disease 2019 (COVID-19) often have a higher probability of organ failure and mortality. The...
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Coffee as a dietary strategy to prevent SARS-CoV-2 infection
BackgroundTo date, most countries lifted the restriction requirement and coexisted with SARS-CoV-2. Thus, dietary behavior for preventing SARS-CoV-2...
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Computational Methodology for Discovery of Potential Inhibitory Peptides
In 2020, a new pandemic caused by a coronavirus has impacted the economic and public health landscape on a global level. Named SARS-CoV-2, it causes...