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Context-dependent TGFβ family signalling in cell fate regulation
The transforming growth factor-β (TGFβ) family are a large group of evolutionarily conserved cytokines whose signalling modulates cell fate...
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αv Integrin-Dependent TGFβ Activation in Cancer: A Brief Update
It is increasingly clear that TGFβ is probably the most important molecule promoting the immunosuppressive state of the tumour microenvironment...
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Control of TGFβ signalling by ubiquitination independent function of E3 ubiquitin ligase TRIP12
Transforming growth factor β (TGFβ) pathway is a master regulator of cell proliferation, differentiation, and death. Deregulation of TGFβ signalling...
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Comprehensive molecular interaction map of TGFβ induced epithelial to mesenchymal transition in breast cancer
Breast cancer is one of the prevailing cancers globally, with a high mortality rate. Metastatic breast cancer (MBC) is an advanced stage of cancer,...
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Cell-free ascites from ovarian cancer patients induces Warburg metabolism and cell proliferation through TGFβ-ERK signaling
Ascites plays a key role in supporting the metastatic potential of ovarian cancer cells. Shear stress and carry-over of cancer cells by ascites flow...
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Humanin activates integrin αV–TGFβ axis and leads to glioblastoma progression
The role of mitochondria peptides in the spreading of glioblastoma remains poorly understood. In this study, we investigated the mechanism underlying...
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ADAMTSL3 knock-out mice develop cardiac dysfunction and dilatation with increased TGFβ signalling after pressure overload
Heart failure is a major cause of morbidity and mortality worldwide, and can result from pressure overload, where cardiac remodelling is...
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The long non-coding RNA LINC00707 interacts with Smad proteins to regulate TGFβ signaling and cancer cell invasion
BackgroundLong non-coding RNAs (lncRNAs) regulate cellular processes by interacting with RNAs or proteins. Transforming growth factor β (TGFβ)...
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TGFβ signaling links early life endocrine-disrupting chemicals exposure to suppression of nucleotide excision repair in rat myometrial stem cells
Environmental exposure to endocrine-disrupting chemicals (EDCs) is linked to the development of uterine fibroids (UFs) in women. UFs, non-cancerous...
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Short telomeres impede germ cell specification by upregulating MAPK and TGFβ signaling
Functional telomeres protect chromosome ends and play important roles in stem cell maintenance and differentiation. Short telomeres negatively impact...
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PHF13 epigenetically activates TGFβ driven epithelial to mesenchymal transition
Epigenetic alteration is a pivotal factor in tumor metastasis. PHD finger protein 13 (PHF13) is a recently identified epigenetic reader of H3K4me2/3...
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KIT promotes tumor stroma formation and counteracts tumor-suppressive TGFβ signaling in colorectal cancer
Expression profiling has identified four consensus molecular subtypes (CMS1-4) in colorectal cancer (CRC). The receptor tyrosine kinase KIT has been...
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MicroRNA-499-5p inhibits transforming growth factor-β1-induced Smad2 signaling pathway and suppresses fibroblast proliferation and collagen synthesis in rat by targeting TGFβ-R1
BackgroundAtrial fibrosis has been recognized as a typical pathological change in atrial fibrillation. Although present evidence suggests that...
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Modeling Cellular Signaling Variability Based on Single-Cell Data: The TGFβ-SMAD Signaling Pathway
Nongenetic heterogeneity is key to cellular decisions, as even genetically identical cells respond in very different ways to the same external...
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A versatile Halo- and SNAP-tagged BMP/TGFβ receptor library for quantification of cell surface ligand binding
TGFβs, BMPs and Activins regulate numerous developmental and homeostatic processes and signal through hetero-tetrameric receptor complexes composed...
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Regulation of self-renewal and senescence in primitive mesenchymal stem cells by Wnt and TGFβ signaling
BackgroundThe therapeutic application of multipotent mesenchymal stem cells (MSCs) encounters significant challenges, primarily stemming from their...
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Recruitment of LEF1 by Pontin chromatin modifier amplifies TGFBR2 transcription and activates TGFβ/SMAD signalling during gliomagenesis
Synergies of transcription factors, chromatin modifiers and their target genes are vital for cell fate determination in human cancer. Although the...
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Hsa_circ_0001485 promoted osteogenic differentiation by targeting BMPR2 to activate the TGFβ-BMP pathway
BackgroundCircular RNAs (circRNAs) are a new type of stable noncoding RNA and have been proven to play a crucial role in osteoporosis. This study...
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Loss of tumor suppressor WWOX accelerates pancreatic cancer development through promotion of TGFβ/BMP2 signaling
Pancreatic cancer is one of the most lethal cancers, owing to its late diagnosis and resistance to chemotherapy. The tumor suppressor WW...
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PALB2-mutated human mammary cells display a broad spectrum of morphological and functional abnormalities induced by increased TGFβ signaling
Heterozygous mutations in any of three major genes, BRCA1 , BRCA2 and PALB2 , are associated with high-risk hereditary breast cancer susceptibility...
