Search
Search Results
-
Functional molecular switches of mammalian G protein-coupled bitter-taste receptors
Bitter taste receptors (TAS2Rs) are a poorly understood subgroup of G protein-coupled receptors (GPCRs). The experimental structure of these...
-
Inhibiting a promiscuous GPCR: iterative discovery of bitter taste receptor ligands
The human GPCR family comprises circa 800 members, activated by hundreds of thousands of compounds. Bitter taste receptors, TAS2Rs, constitute a...
-
Membrane-bound chemoreception of bitter bile acids and peptides is mediated by the same subset of bitter taste receptors
The vertebrate sense of taste allows rapid assessment of the nutritional quality and potential presence of harmful substances prior to ingestion....
-
-
Physiological activation of human and mouse bitter taste receptors by bile acids
Beside the oral cavity, bitter taste receptors are expressed in several non-gustatory tissues. Whether extra-oral bitter taste receptors function as...
-
Expression of TAS2R14 in the intestinal endocrine cells of non-human primates
BackgroundRecent studies have demonstrated that genes related to bitter taste receptors (TAS2Rs) on various chromosomes are expressed in extra-oral...
-
Umami Taste as a Component of Healthy Diets
The effects of climate change on food production, together with the economic downturn caused by the COVID-19 pandemic, have challenged the true...
-
Epigenetic silencing of OR and TAS2R genes expression in human orbitofrontal cortex at early stages of sporadic Alzheimer’s disease
Modulation of brain olfactory ( OR ) and taste receptor ( TASR ) expression was recently reported in neurological diseases. However, there is still...
-
Altered expression levels of TAS1R2 and TAS1R3 genes among SARS-CoV-2 variants of concerns
BackgroundThe most common symptoms of coronavirus infections are fever, cough, shortness of breath, headache, ache of joints, a loss of smell and...
-
Color vision evolution in egg-laying mammals: insights from visual photoreceptors and daily activities of Australian echidnas
Egg-laying mammals (monotremes) are considered “primitive” due to traits such as oviparity, cloaca, and incomplete homeothermy, all of which they...
-
Bitter Taste and Olfactory Receptors: Beyond Chemical Sensing in the Tongue and the Nose
AbstractThe Up-and-Coming-Scientist section of the current issue of the Journal of Membrane Biology features the invited essay by Dr. Mercedes...
-
Allelochemicals targeted to balance competing selections in African agroecosystems
Among major cereals domesticated as staple food, only sorghum has a high proportion of cultivars with condensed tannins in grain, which can trigger...
-
Reduction of bitter taste receptor gene family in folivorous colobine primates relative to omnivorous cercopithecine primates
Bitter taste perception is important in preventing animals from ingesting potentially toxic compounds. Whole-genome assembly (WGA) data have revealed...
-
Characterization and phylogeny of bitter taste receptor genes (Tas2r) in Squamata
The perception of bitter taste is linked to the detection of toxins. Therefore, it facilitates avoiding the consumption of potential toxins in the...
-
Human subsistence and signatures of selection on chemosensory genes
Chemosensation (olfaction, taste) is essential for detecting and assessing foods, such that dietary shifts elicit evolutionary changes in vertebrate...
-
Sensory Property and Phenolic Profile of Aronia Juice
Aronia berry juice is recognized for its unique sensory attributes, abundant phenolic compounds, and multiple health benefits. “Fruity” odor, majorly...
-
Evolution of the bitter taste receptor TAS2R38 in colobines
Bitter taste perception enables the detection of potentially toxic molecules and thus evokes avoidance behavior in vertebrates. It is mediated by...
-
Bitter taste receptors are expressed in human epithelial ovarian and prostate cancers cells and noscapine stimulation impacts cell survival
Bitter taste receptors (Tas2Rs) are a subfamily of G-protein coupled receptors expressed not only in the oral cavity but also in several extra-oral...
-
Rational design of agonists for bitter taste receptor TAS2R14: from modeling to bench and back
Human bitter taste receptors (TAS2Rs) are a subfamily of 25 G protein-coupled receptors that mediate bitter taste perception. TAS2R14 is the most...
-
A vertebrate-wide catalogue of T1R receptors reveals diversity in taste perception
Taste is a vital chemical sense for feeding behaviour. In mammals, the umami and sweet taste receptors comprise three members of the taste receptor...
