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Safety and Efficacy of DT-DEC01 Therapy in Duchenne Muscular Dystrophy Patients: A 12 - Month Follow-Up Study After Systemic Intraosseous Administration
Duchenne Muscular Dystrophy (DMD) is a progressive and fatal muscle-wasting disease with no known cure. We previously reported the preliminary safety...
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Dystrophin Expressing Chimeric (DEC) Cell Therapy for Duchenne Muscular Dystrophy: A First-in-Human Study with Minimum 6 Months Follow-up
Duchenne Muscular Dystrophy (DMD) is a X-linked progressive lethal muscle wasting disease for which there is no cure. We present first-in-human study...
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Long-Term Protective Effect of Human Dystrophin Expressing Chimeric (DEC) Cell Therapy on Amelioration of Function of Cardiac, Respiratory and Skeletal Muscles in Duchenne Muscular Dystrophy
Duchenne Muscular Dystrophy (DMD) is a lethal disease caused by mutations in dystrophin encoding gene, causing progressive degeneration of cardiac,...
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Considerations Pertaining to Implant Sites for Cell-Based Insulin Replacement Therapies
Pancreatic islet transplantation (ITx) established proof of concept that cellular therapies are feasible options to manage intractable severe and...
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Cell Therapy Strategies on Duchenne Muscular Dystrophy: A Systematic Review of Clinical Applications
Duchenne Muscular Dystrophy (DMD) is an inherited genetic disorder characterized by progressive degeneration of muscle tissue, leading to functional...
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Nanoparticular and other carriers to deliver lactoferrin for antimicrobial, antibiofilm and bone-regenerating effects: a review
Bone and joint infections are a rare but serious problem worldwide. Lactoferrin’s antimicrobial and antibiofilm activity coupled with its...
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Therapeutic Options for Diarrheagenic Escherichia coli
Although diarrheagenic E. coli (DEC)Diarrheagenic pathotypes cause diarrheaDiarrhea by different mechanisms, a critical clinical sign that places a...
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Cardiac Protection after Systemic Transplant of Dystrophin Expressing Chimeric (DEC) Cells to the mdx Mouse Model of Duchenne Muscular Dystrophy
Duchenne Muscular Dystrophy (DMD) is a progressive lethal disease caused by X-linked mutations of the dystrophin gene. Dystrophin deficiency...
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Morbid Cell Status and Donor Age Significantly Alter Mesenchymal Stem Cell Functionality and Reparability
Bone marrow (BM)-derived mesenchymal stem cells (MSCs) differentiate into specialized tissues, including cardiomyocytes, endothelial cells, and...
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Morbid Cell Status and Donor Age Significantly Alter Mesenchymal Stem Cell Functionality and Reparability
Bone marrow (BM)-derived mesenchymal stem cells (MSCs) differentiate into specialized tissues, including cardiomyocytes, endothelial cells, and...
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Predictive and prognostic biomarkers of bone metastasis in breast cancer: current status and future directions
The most common site of metastasis in breast cancer is the bone, where the balance between osteoclast-mediated bone resorption and...
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SIRT2 regulates extracellular vesicle-mediated liver–bone communication
The interplay between liver and bone metabolism remains largely uncharacterized. Here, we uncover a mechanism of liver-bone crosstalk regulated by...
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Ophthalmology of Psittaciformes: Parrots and Relatives
Psittaciformes is an ancient order among modern birds, distributed across over 90 genera totaling nearly 400 species (Forshaw 1989; Sibley and...
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Mesenchymal stem cells in the treatment of osteogenesis imperfecta
Osteogenesis imperfecta (OI) is a disease caused by mutations in different genes resulting in mild, severe, or lethal forms. With no cure,...
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Intra-iliac bone marrow injection as a novel alternative to intra-tibial inoculation in rat model
BackgroundIntra-bone marrow injection (IBMI) in rats is adopted in many studies for stem cell and hematopoietic cell transplantation. IBMI in the...
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The therapeutic potential of mesenchymal stem cells in treating osteoporosis
Osteoporosis (OP), a common systemic metabolic bone disease, is characterized by low bone mass, increasing bone fragility and a high risk of...
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Considerations for Clinical Use of Mesenchymal Stromal Cells
The clinical application of stem cells continues to fascinate the scientific and clinical communities. Despite the controversies surrounding this...
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Considerations for Clinical Use of Mesenchymal Stromal Cells
The clinical application of stem cells continues to fascinate the scientific and clinical communities. Despite the controversies surrounding this...
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Lipid metabolism within the bone micro-environment is closely associated with bone metabolism in physiological and pathophysiological stages
Recent advances in society have resulted in the emergence of both hyperlipidemia and obesity as life-threatening conditions in people with...
