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Synthetic Biology Approaches to Posttranslational Regulation in Plants
AbstractTo date synthetic biology approaches involving creation of functional genetic modules are used in a wide range of organisms. In plants, such...
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Antimicrobial and Antibiofilm Activity of Synthetic Peptide [W7]KR12-KAEK Against Enterococcus faecalis Strains
The emergence of infections caused by microorganisms in the oral cavity and increasing concerns regarding the use of antibiotics have resulted in the...
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A synthetic population-level oscillator in non-microfluidic environments
Synthetic oscillators have become a research hotspot because of their complexity and importance. The construction and stable operation of oscillators...
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Review on advancements of pyranopyrazole: synthetic routes and their medicinal applications
Pyranopyrazoles are among the most distinguished, biologically potent, and exciting scaffolds in medicinal chemistry and drug discovery. Synthesis...
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The modulation of autophagy and unfolded protein response by ent-kaurenoid derivative CPUK02 in human colorectal cancer cells
BackgroundCPUK02 (15-Oxosteviol benzyl ester) is a semi-synthetic derivative of stevioside known for its anticancer effects. It has been reported...
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Synthetic account on indoles and their analogues as potential anti-plasmodial agents
Malaria caused by P. falciparum , has been recognized as one of the major infectious diseases causing the death of several patients as per the reports...
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Innovative cascade reaction for 2H-indazole derivative synthesis
In the realm of synthetic organic chemistry, by using a one-pot sequential combination of MCR, it is possible to manufacture chemical commodities...
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Synthetic Activators of Autophagy
AbstractAutophagy is a central process for degradation of intracellular components that do not operate correctly. Molecular mechanisms underlying...
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Enabling technology and core theory of synthetic biology
Synthetic biology provides a new paradigm for life science research (“build to learn”) and opens the future journey of biotechnology (“build to...
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Synthesis and Optical Properties of the Conformationally Locked Diarylmethene Derivative of the GFP Chromophore
Abstract—We report a novel derivative of the conformationally locked derivative of the green fluorescent protein chromophore, ( Z )-5-((2-(difluoroboryl)-4-(dimethylamino)phenyl)(4-(dimethylamino)phenyl)methylene)-2-propyl-3,5-dihydro-4...
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Engineering Whole-Cell Biosensors for Enhanced Detection of Environmental Antibiotics Using a Synthetic Biology Approach
Bacterial Two component systems have evolved with many intricate sensory apparatuses for external stimuli like light, temperature, oxygen, pH and...
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Modeling Subcellular Protein Recruitment Dynamics for Synthetic Biology
Compartmentalized protein recruitment is a fundamental feature of signal transduction. Accordingly, the cell cortex is a primary site of signaling...
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Recent synthetic approaches towards thienothiophenes: a potential template for biologically active compounds
Heterocyclic compounds are attractive candidates because of their vast applications in natural and physical sciences. Thienothiophene (TT) is an...
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A375 melanoma cells are sensitized to cisplatin-induced toxicity by a synthetic nitro-flavone derivative 2-(4-Nitrophenyl)-4H-chromen-4-one through inhibition of PARP1
BackgroundCisplatin has been extensively used in therapeutics for its broad-spectrum anticancer activity and frequently used for the treatment of...
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Triazole Moieties as Potent Drug Molecules: Synthetic Approaches and Application as Promising Candidates as Anticancer Agents (A Review)
AbstractDespite considerable progress in the field of anticancer agent development, there remains a demand for more efficacious and safer drugs. The...
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Low impact of polyploidization on the transcriptome of synthetic allohexaploid wheat
BackgroundBread wheat is a recent allohexaploid (genomic constitution AABBDD) that emerged through a hybridization between tetraploid Triticum...
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Pre-clinical evaluation of 99mTc-labeled chalcone derivative for amyloid-β imaging post-head trauma
Aβ 42 plaque formation is one of the preliminary pathologic events that occur post traumatic brain injury (TBI) which is also among the most...
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Study of Antimicrobial Effect of a New Fluoroquinolone Derivative Against Pathogenic Bacteria in Planktonic Form and Biofilm
The emergence of pathogenic bacterial strains resistant to currently available antimicrobial agents is a universal problem of arising importance....
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Biotechnological production of specialty aromatic and aromatic-derivative compounds
Aromatic compounds are an important class of chemicals with different industrial applications. They are usually produced by chemical synthesis from...
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Insights into enterovirus a-71 antiviral development: from natural sources to synthetic nanoparticles
Enteroviruses are pathogens responsible for several diseases, being enterovirus A71 (EVA71) the second leading cause of hand, foot, and mouth disease...
