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Parallel evolution of cannabinoid biosynthesis
Modulation of the endocannabinoid system is projected to have therapeutic potential in almost all human diseases. Accordingly, the high demand for...
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Displacement Binding Assay Using Human Cannabinoid CB2 Receptor-Transfected Cells
Displacement binding assays are nonfunctional assays mostly used with the aim of determining whether a certain compound (plant-derived or synthetic)...
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Cyclic AMP Assay Using Human Cannabinoid CB2 Receptor-Transfected Cells
The cyclic AMP assay is a functional assay that is commonly used to determine the pharmacological behavior (agonists, antagonists, and inverse...
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Activation of the Cannabinoid Receptors Suppresses Hyperexcitation of Rat Hippocampal Neuronal Networks In Vitro
Abstract—Cannabinoid receptors (CBRs) play a key role in various physiological processes, including neurogenesis, synaptic plasticity, immune...
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Cannabinoid and endocannabinoid system: a promising therapeutic intervention for multiple sclerosis
Multiple sclerosis (MS) is a chronic and complex neurodegenerative disease, distinguished by the presence of lesions in the central nervous system...
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Biosynthesis of cannabinoid precursor olivetolic acid in genetically engineered Yarrowia lipolytica
Engineering microbes to produce plant-derived natural products provides an alternate solution to obtain bioactive products. Here we report a...
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Combined alcohol and cannabinoid exposure leads to synergistic toxicity by affecting cerebellar Purkinje cells
Combined use of cannabis and alcohol results in greater psychoactive toxicity than either substance alone, but the underlying central mechanisms...
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Engineering the amoeba Dictyostelium discoideum for biosynthesis of a cannabinoid precursor and other polyketides
Aromatic polyketides are natural polyphenolic compounds with a broad spectrum of pharmacological activities. Production of those metabolites in the...
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Cannabinoid CB1 receptor gene inactivation in oligodendrocyte precursors disrupts oligodendrogenesis and myelination in mice
Cannabinoids are known to modulate oligodendrogenesis and developmental CNS myelination. However, the cell-autonomous action of these compounds on...
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Cannabinoid receptor 2 activation alleviates diabetes-induced cardiac dysfunction, inflammation, oxidative stress, and fibrosis
Diabetes mellitus promotes accelerated cardiovascular aging and inflammation, which in turn facilitate the development of cardiomyopathy/heart...
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Clinical Pharmacology of Capsaicin, Its Synthetic and Semisynthetic Analogues
The spicy flavour of chilli pepper fruit comes from chemicals, called capsaicinoids. Capsaicin, dihydrocapsaicin, nordihydrocapsaicin,...
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Enabling technology and core theory of synthetic biology
Synthetic biology provides a new paradigm for life science research (“build to learn”) and opens the future journey of biotechnology (“build to...
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Klotho, BDNF, NGF, GDNF Levels and Related Factors in Withdrawal Period in Chronic Cannabinoid Users
Klotho and neurotropic factors have recently been shown to be related to some psychiatric disorders and neurocognitive disorders, but there is no...
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Electrophysiology of Endocannabinoid Signaling
Electrophysiological technique is an efficient tool for investigating the synaptic regulatory effects mediated by the endocannabinoid system....
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Three novel transcription factors involved in cannabinoid biosynthesis in Cannabis sativa L.
Key messageThree novel transcription factors were successfully identified and shown to interact with the trichome-specific THCAS promoter regulatory...
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Cannabis and the Skin
Anandamide mediates transcriptional effects associated with epidermal differentiation and skin development in those cells through a CB1-dependent...
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In-depth comparison of the metabolic and pharmacokinetic behaviour of the structurally related synthetic cannabinoids AMB-FUBINACA and AMB-CHMICA in rats
Synthetic cannabinoids receptor agonists (SCRAs) are often almost completely metabolised, and hence their pharmacokinetics should be carefully...
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Psychotropic Effects of Cannabis
Brain development is a complex phenomenon from fetal life to adolescence. During this period, the brain’s maturation proceeds through a series of...
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Endocannabinoid-Binding Receptors as Drug Targets
Cannabis plant has been used from ancient times with therapeutic purposes for treating human pathologies, but the identification of the cellular and...