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Antitumor activity of adiponectin in mice model of skin cancer via modulation of sulfatase-2 and MMP9 activity on HSPGs
Incidence and progression of skin cancer has progressively elevated in the last decades because of the increase in risk factors such as ultraviolet...
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Measurement of Mucinase Activity
Mucinase consists of some proteases, glycosidases, sulfatases, and sialidases. It is not practical to measure individual enzyme activities when...
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Structural Organization of the Active Center of Unmodified Recombinant Sulfatase from the Mycelial Fungi Fusarium proliferatum LE1
Abstract —Sulfatases catalyze the hydrolysis of sulfuric acid esters and play a key role in a number of biological processes of both higher eukaryotes...
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Conservation tillage increases nutrient accumulation by promoting soil enzyme activity: a meta-analysis
AimsThe conservation tillage i.e. reduced tillage (incl. no tillage and minimum tillage) and straw return, plays an important role in the promotion...
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Association between SUMF1 polymorphisms and COVID-19 severity
BackgroundEvidence shows that genetic factors play important roles in the severity of coronavirus disease 2019 (COVID-19). Sulfatase modifying factor...
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Structural tailoring of fucoidan backbones for maximizing their benefits: Enzymatic, chemical, and physical strategies
Fucoidans are a heterogenous class of sulfated, fucose-rich, and high molecular weight polysaccharides derived mainly from brown seaweeds. They have...
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Metagenomic, (bio)chemical, and microscopic analyses reveal the potential for the cycling of sulfated EPS in Shark Bay pustular mats
Cyanobacteria and extracellular polymeric substances (EPS) in peritidal pustular microbial mats have a two-billion-year-old fossil record. To...
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Agarolytic Pathway in the Newly Isolated Aquimarina sp. Bacterial Strain ERC-38 and Characterization of a Putative β-agarase
Marine microbes, particularly Bacteroidetes, are a rich source of enzymes that can degrade diverse marine polysaccharides. Aquimarina sp. ERC-38,...
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Bioinvasion by Spartina patens alters sediment biogeochemical functioning of European salt marshes
Bioinvasions pose undeniable threats and trigger changes in salt marsh ecosystem functioning. In Mediterranean and Atlantic marshes, the invasion by S....
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Mucopolysaccharidosis type II zebrafish model exhibits early impaired proteasomal-mediated degradation of the axon guidance receptor Dcc
Most of the patients affected by neuronopathic forms of Mucopolysaccharidosis type II (MPS II), a rare lysosomal storage disorder caused by defects...
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Disturbances in mitochondrial bioenergetics and control quality and unbalanced redox homeostasis in the liver of a mouse model of mucopolysaccharidosis type II
Mucopolysaccharidosis type II (MPS II; Hunter syndrome) is a lysosomal storage disease caused by mutations in the gene encoding the enzyme iduronate...
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Enzyme promiscuity in natural environments: alkaline phosphatase in the ocean
Alkaline phosphatase (APase) is one of the marine enzymes used by oceanic microbes to obtain inorganic phosphorus (P i ) from dissolved organic...
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Synthesis, antiproliferative activity, and molecular modeling of novel 4-methylcoumarin derivatives and/or nitric oxide donor hybrids
AbstractTwo new 4-methylcoumarin derivatives ( 3a–f and 4a–f ) were designed, synthesized, and evaluated for their cytotoxic activity. Different...
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Alterations of Plasmatic Biomarkers of Neurodegeneration in Mucopolysaccharidosis Type II Patients Under Enzyme Replacement Therapy
Mucopolysaccharidosis type II (MPS II) is a disorder caused by a deficient activity of iduronate-2-sulfatase, a lysosomal enzyme responsible for...
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Long-Term Grazing Mediates Soil Organic Carbon Dynamics by Reorienting Enzyme Activities and Elemental Stoichiometry in Semi-arid Tropical Inceptisol
Long-term grazing by small ruminants diminishes grass and plant covers, alters various biophysical situations and nutrient stoichiometry and modifies...
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Genomic analysis of heavy metal-resistant Halobacterium salinarum isolated from Sfax solar saltern sediments
The draft genome sequences of five archaeal strains, isolated from Sfax solar saltern sediments and affiliated with Halobacterium salinarum, were...
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The GALNS p.P77R variant is a probable Gujarati-Indian founder mutation causing Mucopolysaccharidosis IVA syndrome
BackgroundMucopolysaccharidosis IVA (Morquio syndrome A, MPS IVA) is an autosomal recessive lysosomal storage disorder caused due to biallelic...
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Description of Aureibaculum luteum sp. nov. and Aureibaculum flavum sp. nov. isolated from Antarctic intertidal sediments
Two Gram-stain-negative, aerobic, non-motile, and rod-shaped bacterial strains, designated SM1352 T and A20 T , were isolated from intertidal sediments...
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Peatland Plant Functional Type Effects on Early Decomposition Indicators are Non-Pervasive, but Microhabitat Dependent
Ombrotrophic peatlands are important long-term sinks for atmospheric carbon as plant productivity exceeds litter decomposition. Changes in plant...
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Agricultural management practices influence the soil enzyme activity and bacterial community structure in tea plantations
BackgroundThe soil quality and health of the tea plantations are dependent on agriculture management practices, and long-term chemical fertilizer use...
