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Dosing interval regimen shapes potency and breadth of antibody repertoire after vaccination of SARS-CoV-2 RBD protein subunit vaccine
Vaccination with different vaccines has been implemented globally to counter the continuous COVID-19 pandemic. However, the vaccine-elicited...
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A variant-proof SARS-CoV-2 vaccine targeting HR1 domain in S2 subunit of spike protein
The emerging SARS-CoV-2 variants, commonly with many mutations in S1 subunit of spike (S) protein are weakening the efficacy of the current vaccines...
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Evaluation of immunogenicity and protective efficacy of bacteriophage conjugated haemagglutinin based subunit vaccine against equine influenza virus in a murine model
Equine influenza (EI) is a highly contagious acute respiratory disease of equines caused by the H3N8 subtype of Influenza A virus i.e. equine...
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Plant Molecular Farming for Vaccine Development
Vaccines are effective tools for the prophylaxis of infectious diseases. Various diseases have been eradicated using vaccines, and the importance of...
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Development of Multi-epitope Based Subunit Vaccine Against Crimean-Congo Hemorrhagic Fever Virus Using Reverse Vaccinology Approach
Crimean-Congo hemorrhagic fever (CCHF) is a viral disease caused by the Crimean-Congo hemorrhagic fever virus (CCHFV) of the Nairovirus genus. CCHF...
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Immunoinformatics Approach to Design a Novel Subunit Vaccine Against Visceral Leishmaniasis
Visceral leishmaniasis (VL) infection is mostly caused by Leishmania donovani and affects countries worldwide. Despite the need for a safe and...
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Synthesis of plant-based, self-adjuvanted, dual antigen specific to Mycobacterium tuberculosis as a novel tuberculosis subunit vaccine that elicits immunogenicity in rabbit
ObjectivesThe only approved vaccine, Bacillus Calmette Guérin (BCG) used in global tuberculosis (TB) immunization programmes has been very effective...
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Exploratory Algorithm of a Multi-epitope-based Subunit Vaccine Candidate Against Cryptosporidium hominis: Reverse Vaccinology-Based Immunoinformatic Approach
Cryptosporidiosis is the leading protozoan-induced cause of diarrheal illness in children, and it has been linked to childhood mortality,...
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Analysis of Alternative Splicing and Long Noncoding RNAs After the Edwardsiella anguillarum Infected the Immunized European Eels (Anguilla anguilla) Revealed the Role of Outer Membrane Protein A in OmpA Subunit Vaccine
Edwardsiella anguillarum is a bacterium that commonly infects cultivated eels. Outer membrane protein A (OmpA) emulsified with Freund’s adjuvant has...
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A conserved subunit vaccine designed against SARS-CoV-2 variants showed evidence in neutralizing the virus
AbstractNovel coronavirus (SARS-CoV-2) leads to coronavirus disease 19 (COVID-19), declared as a pandemic that outbreaks within almost 225 countries...
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Development, Strategies, and Challenges for Tularemia Vaccine
Francisella tularensis is a facultative intracellular bacterial pathogen that affects both humans and animals. It was developed into a biological...
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Preparation of Trimethyl Chitosan-Based Polyelectrolyte Complexes for Peptide Subunit Vaccine Delivery
A variety of delivery vehicles have been explored as adjuvanting/delivery platforms for peptide-based subunit vaccines. Polysaccharide-based systems...
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Development of recombinant subunit vaccine targeting InvH protein of Salmonella Typhimurium and evaluation of its immunoprotective efficacy against salmonellosis
Salmonella Typhimurium is the most prevalent non-host specific Salmonella serovars and a major concern for both human and animal health systems...
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Recent progress and major gaps in the vaccine development for African swine fever
The swine industry across the globe is recently facing a devastating situation imparted by a highly contagious and deadly viral disease, African...
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Evaluating the Performance of PPE44, HSPX, ESAT-6 and CFP-10 Factors in Tuberculosis Subunit Vaccines
Mycobacterium tuberculosis ( M. tuberculosis ) is an intracellular pathogen causing long-term infection in humans that mainly attacks macrophages and...
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Fish oral vaccine and mucosal immunity
Fish can be vaccinated by injection, intramuscularly (IM) or intraperitoneally (IP), and orally. Using oral immunization provides the most attractive...
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RBD-homodimer, a COVID-19 subunit vaccine candidate, elicits immunogenicity and protection in rodents and nonhuman primates
The pandemic of COVID-19 caused by SARS-CoV-2 has raised a new challenges to the scientific and industrious fields after over 1-year spread across...
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Proteome based analysis of circulating SARS-CoV-2 variants: approach to a universal vaccine candidate
The discovery of the first infectious variant in Wuhan, China, in December 2019, has posed concerns over global health due to the spread of COVID-19...
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Development of Heterologous Expression System and Optimization of the Method of Cholera Toxin β-Subunit Production in E. coli
AbstractCholera is a deadly infection disease, which is usually associated with low hygiene levels and limited access to high-quality drinking water....
