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A resource database for protein kinase substrate sequence-preference motifs based on large-scale mass spectrometry data
BackgroundProtein phosphorylation is one of the most prevalent posttranslational modifications involved in molecular control of cellular processes,...
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SPOP point mutations regulate substrate preference and affect its function
The adaptor SPOP recruits substrates to CUL3 E3 ligase for ubiquitination and degradation. Structurally, SPOP harbors a MATH domain for substrate...
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Lysyl oxidase-like 2 processing by factor Xa modulates its activity and substrate preference
Lysyl oxidase-like 2 (LOXL2) has been identified as an essential mediator of extracellular matrix (ECM) remodeling in several disease processes...
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Fear of the dark: substrate preference in Amazonian tadpoles
Due to the importance of camouflage to avoid detection by predators, predation pressure can cause coupled evolution of skin colour and preference for...
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Frequency-preference response in covalent modification cycles under substrate sequestration conditions
Covalent modification cycles (CMCs) are basic units of signaling systems and their properties are well understood. However, their behavior has been...
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Intra-species variation of ovipositor morphology and oviposition preference in Drosophila suzukii (Diptera: Drosophilidae)
Females of Drosophila suzukii have an enlarged and sclerotized ovipositor (oviscapt, hypogynium), which is a key evolutionary trait that enabled D....
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The relationship between preference and switching in flower foraging by bees
It seems self-evident that generalist foragers switch more between resources than specialists but despite diverse ecological and evolutionary...
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Rational engineering of an elevator-type metal transporter ZIP8 reveals a conditional selectivity filter critically involved in determining substrate specificity
Engineering of transporters to alter substrate specificity as desired holds great potential for applications, including metabolic engineering....
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An ancient metalloenzyme evolves through metal preference modulation
Evolution creates functional diversity of proteins, the essential building blocks of all biological systems. However, studies of natural proteins...
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Transesterification with CE15 glucuronoyl esterase from Cerrena unicolor reveals substrate preferences
PurposeGlucuronoyl esterases (GE, family CE15) catalyse the cleavage of ester linkages in lignin-carbohydrate complexes (LCCs), and this study...
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Preference of Bemisia tabaci MED (Hemiptera: Aleyrodidae) among morphologically and physically distinct tomato genotypes
The recent introduction of Bemisia tabaci (Gennadius) MED (Hemiptera: Aleyrodidae) in the main tomato-producing areas in Brazil is concerning due to...
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Discovery of NSD2 non-histone substrates and design of a super-substrate
The human protein lysine methyltransferase NSD2 catalyzes dimethylation at H3K36. It has very important roles in development and disease but many...
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Evidence for an innate basis of prey preference in a desert ambush predator
Chemical eavesdrop** is a critical tool used by organisms to gain information about their environment and mediate interactions with other organisms...
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Evaluation of maize genotypes on oviposition preference of Diabrotica speciosa (Germar)
Diabrotica speciosa (Germar) is a pest of economic importance for several crops in South and Central America, causing damage to plants in both the...
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Nutrient uptake in supplemented substrate by oyster mushroom
Spent mushroom substrate (SMS) is a promising alternative for supplementing oyster mushroom substrate, replacing conventional cereal bran. Therefore,...
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Determinants of substrate specificity in a catalytically diverse family of acyl-ACP thioesterases from plants
BackgroundACYL-LIPID THIOESTERASES (ALTs) are a subclass of plastid-localized, fatty acyl-acyl carrier protein (ACP) thioesterase enzymes from...
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Does littoral substrate affect macroinvertebrate assemblages in Mediterranean lakes?
The objective of this study was to investigate the effects of substrate type in macroinvertebrate assemblages in Mediterranean lakes. Samplings have...
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Lack of Female Preference for Nuptial Gifts May Have Led to Loss of the Male Sexual Trait
Evolutionary loss of sexual traits may occur if the forces that maintain those traits weaken or disappear. Females may evolve resistance or a change...
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The Arabidopsis AtSWEET13 transporter discriminates sugars by selective facial and positional substrate recognition
Transporters are targeted by endogenous metabolites and exogenous molecules to reach cellular destinations, but it is generally not understood how...
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Investigating the effect of substrate binding on the catalytic activity of xylanase
AbstractXynAF1 from Aspergillus fumigatus Z5 is an efficient thermophilic xylanase belonging to glycoside hydrolase family 10 (GH10). The...
