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1. Aquaporin ion conductance properties defined by membrane environment, protein structure, and cell physiology

   Aquaporins (AQPs) are multifunctional transmembrane channel proteins permeable to water and an expanding array of solutes. AQP-mediated ion channel...

   Sam W. Henderson, Saeed Nourmohammadi, ... Andrea J. Yool in Biophysical Reviews

   Article 11 January 2022
   

2. Structural mechanism of TRPM7 channel regulation by intracellular magnesium

   Zn ²⁺ , Mg ²⁺ and Ca ²⁺ are essential divalent cations implicated in many metabolic processes and signalling pathways. An emerging new paradigm is that...

   Eva Schmidt, Chamali Narangoda, ... Vladimir Chubanov in Cellular and Molecular Life Sciences

   Article Open access 07 April 2022
   

3. Disruption of ER ion homeostasis maintained by an ER anion channel CLCC1 contributes to ALS-like pathologies

   Although anion channel activities have been demonstrated in sarcoplasmic reticulum/endoplasmic reticulum (SR/ER), their molecular identities and...

   Liang Guo, Qionglei Mao, ... Yichang Jia in Cell Research

   Article Open access 04 May 2023
   

4. Analysis of patchclamp recordings: model-free multiscale methods and software

   Analysis of patchclamp recordings is often a challenging issue. We give practical guidance how such recordings can be analyzed using the model-free...

   Florian Pein, Benjamin Eltzner, Axel Munk in European Biophysics Journal

   Article Open access 01 March 2021
   

5. Mitochondrial ATP synthase c-subunit leak channel triggers cell death upon loss of its F₁ subcomplex

   Mitochondrial ATP synthase is vital not only for cellular energy production but also for energy dissipation and cell death. ATP synthase c-ring was...

   Nelli Mnatsakanyan, Han-A Park, ... Elizabeth A. Jonas in Cell Death & Differentiation

   Article Open access 23 March 2022
   

6. Prokaryotic and Eukaryotic Porins: Comparison of Structure and Function

   Gram-negative bacteria are presumably more than 4 billion years old. They are surrounded by two membranes, the bacterial inner and the outer...

   Roland Benz in Developmental Biology in Prokaryotes and Lower Eukaryotes

   Chapter 2021
   

7. Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation

   Protein aggregation and abnormal lipid homeostasis are both implicated in neurodegeneration through unknown mechanisms. Here we demonstrate that...

   Plamena R. Angelova, Minee L. Choi, ... Sonia Gandhi in Cell Death & Differentiation

   Article Open access 27 April 2020
   

8. Panx1 channels promote both anti- and pro-seizure-like activities in the zebrafish via p2rx7 receptors and ATP signaling

   The molecular mechanisms of excitation/inhibition imbalances promoting seizure generation in epilepsy patients are not fully understood. Evidence...

   Paige Whyte-Fagundes, Daria Taskina, ... Georg R. Zoidl in Communications Biology

   Article Open access 18 May 2022
   

9. Design, assembly, and characterization of membrane-spanning DNA nanopores

   DNA nanopores are bio-inspired nanostructures that control molecular transport across lipid bilayer membranes. Researchers can readily engineer the...

   Conor Lanphere, Daniel Offenbartl-Stiegert, ... Stefan Howorka in Nature Protocols

   Article 21 December 2020
   

10. Gap Junction Proteins (Connexins, Pannexins, and Innexins)

    Eliana Scemes, David C. Spray in Encyclopedia of Biophysics

    Living reference work entry 2019
    

11. TRP Channel Reconstitution in Lipid Bilayers

    The family of the transient receptor potential (TRP) proteins presents a diverse group of polymodal ion channels intertwined in the regulation of...

    Eleonora Zakharian in TRP Channels

    Protocol 2019
    

12. Cholesterol-Dependent Gating Effects on Ion Channels

    Biomembranes separate a live cell from its environment and keep it in an off-equilibrium, steady state. They contain both phospholipids and...

    Qiu-**ng Jiang in Cholesterol Modulation of Protein Function

    Chapter 2019
    

13. Cannabidiol directly targets mitochondria and disturbs calcium homeostasis in acute lymphoblastic leukemia

    Anticancer properties of non-psychoactive cannabinoid cannabidiol (CBD) have been demonstrated on tumors of different histogenesis. Different...

    Miguel Olivas-Aguirre, Liliana Torres-López, ... Oxana Dobrovinskaya in Cell Death & Disease

    Article Open access 14 October 2019
    

14. Moving average filtering with deconvolution (MAD) for hidden Markov model with filtering and correlated noise

    Ion channel data recorded using the patch clamp technique are low-pass filtered to remove high-frequency noise. Almanjahie et al. (Eur Biophys J...

    Ibrahim M. Almanjahie, Ramzan Nazim Khan, ... Boris Martinac in European Biophysics Journal

    Article 27 April 2019
    

15. Mitochondrial Permeability Transition Pore and Calcium Handling

    The opening of a large conductance channel in the inner mitochondrial membrane, known as the mitochondrial permeability transition pore (PTP), has...

    Randi J. Parks, Elizabeth Murphy, Julia C. Liu in Mitochondrial Bioenergetics

    Protocol 2018
    

16. Functional Analysis of Membrane Proteins Produced by Cell-Free Translation

    Cell-free production is a valuable and alternative method for the synthesis of membrane proteins. This system offers openness allowing the...

    Srujan Kumar Dondapati, Doreen A. Wüstenhagen, Stefan Kubick in Protein Engineering

    Protocol Open access 2018
    

17. Scorpion Venom–Toxins that Aid in Drug Development: A Review

    Scorpion venom components have multifaceted orientation against bacterial, viral, fungal infections and other neuronal disorders. They can modulate...

    Arijit Ghosh, Rini Roy, ... Ashis Mukhopadhyay in International Journal of Peptide Research and Therapeutics

    Article 05 June 2018
    

18. Spontaneously opening GABA_A receptors play a significant role in neuronal signal filtering and integration

    Continuous (tonic) charge transfer through ionotropic receptors of γ -aminobutyric acid (GABA _A Rs) is an important mechanism of inhibitory signalling...

    Nathanael O’Neill, Sergiy Sylantyev in Cell Death & Disease

    Article Open access 24 July 2018
    

19. Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2)

    Mutations in either polycystin-1 (PC1 or PKD1) or polycystin-2 (PC2, PKD2 or TRPP1) cause autosomal-dominant polycystic kidney disease (ADPKD)...

    Mariana Grieben, Ashley C W Pike, ... Elisabeth P Carpenter in Nature Structural & Molecular Biology

    Article 19 December 2016
    

20. Structural Details of the Ryanodine Receptor Calcium Release Channel and Its Gating Mechanism

    Ryanodine receptors (RyRs) are large intracellular calcium release channels that play a crucial role in coupling excitation to contraction in both...

    Katrien Willegems, Rouslan G. Efremov in Membrane Dynamics and Calcium Signaling

    Chapter 2017