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Structural Analyses of the Glycolipids in Lipid Rafts
Lipid rafts are usually isolated from cells or tissues using sucrose gradient ultracentrifugation in the presence of detergents such as Triton X-100...
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Microbial Communities: Structural and Functional Analyses with Molecular Biological Approach
Identification and classification are now largely based on sequence analyses of ribosomal RNA (rRNA) or the rDNA encoding it, as well as genes of...
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Cotranscriptional Assembly and Native Purification of Large RNA–RNA Complexes for Structural Analyses
Recent technological developments such as cryogenic electron microscopy (Cryo-EM) and X-ray free electron lasers (XFEL) have significantly expanded...
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A computational approach for structural and functional analyses of disease-associated mutations in the human CYLD gene
Tumor suppressor cylindromatosis protein (CYLD) regulates NF-κB and JNK signaling pathways by cleaving K63-linked poly-ubiquitin chain from its...
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Genome-wide map** and cryo-EM structural analyses of the overlap** tri-nucleosome composed of hexasome-hexasome-octasome moieties
The nucleosome is a fundamental unit of chromatin in which about 150 base pairs of DNA are wrapped around a histone octamer. The overlap**...
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Structural Analyses of Bacterial Effectors by X-Ray Crystallography
X-ray crystallography is a method of choice to determine and analyze protein structures. Although large complexes are challenging to crystallize and...
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Structural and functional analyses of Burkholderia pseudomallei BPSL1038 reveal a Cas-2/VapD nuclease sub-family
Burkholderia pseudomallei is a highly versatile pathogen with ~25% of its genome annotated to encode hypothetical proteins. One such hypothetical...
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Comparative protein structural analyses of α-synuclein linked pathogenic variants reveal the role of N-terminally located critical region in Parkinson’s disease pathogenesis
SNCA was the first gene to be linked to Parkinson's disease (PD). Pathogenic variations in the corresponding neuronal protein α-synuclein are known...
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Genomic, functional and structural analyses elucidate evolutionary innovation within the sea anemone 8 toxin family
BackgroundThe ShK toxin from Stichodactyla helianthus has established the therapeutic potential of sea anemone venom peptides, but many...
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Structural and functional analyses explain Pea KAI2 receptor diversity and reveal stereoselective catalysis during signal perception
KAI2 proteins are plant α/β hydrolase receptors which perceive smoke-derived butenolide signals and endogenous, yet unidentified KAI2-ligands (KLs)....
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Molecular genetics, neuroimaging outcomes, and structural analyses of novel and recurrent variants of WDR62 gene in two consanguineous Pakistani families with autosomal recessive primary microcephaly
BackgroundAutosomal recessive primary microcephaly (MCPH) is a rare neurodevelopmental and genetically heterogeneous disorder, characterized by small...
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Advances in Structural Bioinformatics
Structural bioinformatics is a captivating discipline that delves into the intricate realm related to proteins, RNA, and DNA, the macromolecules of...
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Structural and Functional Analyses of the Flavoprotein Disulfide Reductase FN0820 of Fusobacterium nucleatum
Escherichia coli RclA and Staphylococcus aureus MerA are part of the Group I flavoprotein disulfide reductase (FDR) family and have been implicated...
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Probing RNA Structures and Interactions Using Fluorescence Lifetime Analyses
Structural analyses of large, complex noncoding RNAs continue to lag behind their rapid discovery and functional descriptions. Site-specifically...
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Microbial Communities: Structural and Functional Analyses with Classical Approach
Microorganisms are involved in numerous processes in the environment in a desirable or undesirable manner. At the same time, they practically never...
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Advanced Methods in Structural Biology
This volume explores the latest integrated bioprocesses and technologies used to study the production of the target recombinant protein of...
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Species and structural diversity of trees at the structural type level
BackgroundSpecies and structural diversity are important for understanding the formation of forest communities, key ecological processes, and...
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Structural features of fungal genomes
Eighteen fungal genomes have been sequenced to date from a variety of taxonomic groups, with fifteen Ascomycota, two Basidomycota and one...
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Comparative Analyses of Bacteriophage Genomes
Bacterial viruses (bacteriophages or phages) are the most abundant and diverse biological entities on Earth. There is a renewed worldwide interest in...
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Structural Characterization of Peptide Antibodies
The role of proteins as very effective immunogens for the generation of antibodies is indisputable. Nevertheless, cases in which protein usage for...