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Autophagy regulates sex steroid hormone synthesis through lysosomal degradation of lipid droplets in human ovary and testis
Autophagy is an evolutionarily conserved process that aims to maintain the energy homeostasis of the cell by recycling long-lived proteins and...
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Steroid hormone-dependent changes in trehalose physiology in the silkworm, Bombyx mori
Holometabolous insects undergo metamorphosis to reconstruct their body to the adult form during pupal period. Since pupae cannot take any diets from...
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Hormone und Mediatoren
Hormone dienen, zusammen mit den Wachstumsfaktoren, zur extrazellulären Signalübermittlung. Die strukturell heterogenen Hormone werden in... -
Exposure to Fluoride From in Utero to Puberty Alters Gonadal Structure and Steroid Hormone Expression in Offspring Rats
The reproductive toxicity of fluoride has been proven by a large number of studies. While the underlying mechanism of reproductive toxicity during...
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Effects of 4-vinylcyclohexene diepoxide on the cell cycle, apoptosis, and steroid hormone secretion of goat ovarian granulosa cells
4-Vinylcyclohexene diepoxide (VCD) is a potentially hazardous industrial chemical that may enter a goat’s body in various ways during industrial...
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The multifaceted therapeutic value of targeting steroid receptor coactivator-1 in tumorigenesis
Steroid receptor coactivator-1 (SRC-1, also known as NCOA1) frequently functions as a transcriptional coactivator by directly binding to...
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Juvenil- und Steroid-Hormone
Ausgehend von der Mevalonsäure wird in Vertebraten und Invertebraten aus Isoprenyloligomeren, Squalen und Cholesterin eine Vielzahl von Hormonen... -
Thyroid and Sex Steroid Hormone Level in the Pink Salmon Oncorhynchus gorbuscha during Marine and Freshwater Periods of Spawning Migration
Abstract —Thyroid and sex steroid hormones have been studied in spawners of the pink salmon Oncorhynchus gorbuscha at the stage of changing the...
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Effect of liver receptor homolog-1 on cell apoptosis and steroid hormone secretion on granulosa cells from Hu sheep
The apoptosis of granulosa cells can result in follicular atresia, a key process in follicle selection and development. The related molecular...
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Role of sex hormone-binding globulin in the free hormone hypothesis and the relevance of free testosterone in androgen physiology
According to the free hormone hypothesis, biological activity of a certain hormone is best reflected by free rather than total hormone...
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The Effects of Sex Steroid Hormones on Cardiovascular Physiology in Females
There are fundamental sex-specific differences in cardiovascular (CV) physiology and cardiovascular disease (CVD) pathophysiology. Estrogen, a sex... -
Synthesis of Steroid Tracers by an Oxime Ligation Method and Their Use in Fluorescent Polarisation Immunoassay
Abstractctive: The development of a fast and reliable method for the quantitative evaluation of steroid hormones is very relevant for scientific and...
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Aging induces region-specific dysregulation of hormone synthesis in the primate adrenal gland
Adrenal glands, vital for steroid secretion and the regulation of metabolism, stress responses and immune activation, experience age-related decline,...
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Gut microbiota affects the estrus return of sows by regulating the metabolism of sex steroid hormones
BackgroundSex hormones play important roles in the estrus return of post-weaning sows. Previous studies have demonstrated a complex and...
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Mobilization of cholesterol induces the transition from quiescence to growth in Caenorhabditis elegans through steroid hormone and mTOR signaling
Recovery from the quiescent developmental stage called dauer is an essential process in C. elegans and provides an excellent model to understand how...
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Omega-6 highly unsaturated fatty acids in Leydig cells facilitate male sex hormone production
Highly unsaturated fatty acids (HUFAs) are fatty acids with more than three double bonds in the molecule. Mammalian testes contain very high levels...
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Sex differences in colorectal cancer: with a focus on sex hormone–gut microbiome axis
Sexual dimorphism has been observed in the incidence and prognosis of colorectal cancer (CRC), with men generally exhibiting a slightly higher...
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The steroid hormone estriol (E3) regulates epigenetic programming of fetal mouse brain and reproductive tract
BackgroundEstriol (E 3 ) is a steroid hormone formed only during pregnancy in primates including humans. Although E 3 is synthesized at large amounts...
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EP300/CREBBP acetyltransferase inhibition limits steroid receptor and FOXA1 signaling in prostate cancer cells
The androgen receptor (AR) is a primary target for treating prostate cancer (PCa), forming the bedrock of its clinical management. Despite their...
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Adrenarche-accompanied rise of adrenal sex steroid precursors prevents NAFLD in Young Female rats by converting into active androgens and inactivating hepatic Srebf1 signaling
BackgroundNon-alcoholic fatty liver disease (NAFLD) has rapidly become the most common cause of chronic liver disease in children and adolescents,...