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The Grb2 splice variant, Grb3-3, is a negative regulator of RAS activation
Activation of RAS is crucial in driving cellular outcomes including proliferation, differentiation, migration and apoptosis via the MAPK pathway....
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Transcription Factors and Splice Factors—Interconnected Regulators of Stem Cell Differentiation
Purpose of ReviewThe underlying molecular mechanisms that direct stem cell differentiation into fully functional, mature cells remain an area of...
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TrichomeLess Regulator 3 is required for trichome initial and cuticle biosynthesis in Artemisia annua
Artemisinin is primarily synthesized and stored in the subepidermal space of the glandular trichomes of Artemisia annua . The augmentation of trichome...
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Unpacking the complexity of nuclear IL-33 (nIL-33): a crucial regulator of transcription and signal transduction
Interleukin-33 (IL-33) (NF-HEV), a chromatin-associated nuclear cytokine, is a member of the IL-1 family. IL-33 possesses a nuclear localization...
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Integrated omics analysis identified genes and their splice variants involved in fruit development and metabolites production in Capsicum species
To date, several transcriptomic studies during fruit development have been reported; however, no comprehensive integrated study on expression...
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Analysis of splice variants of the human protein disulfide isomerase (P4HB) gene
BackgroundProtein Disulfide Isomerases are thiol oxidoreductase chaperones from thioredoxin superfamily with crucial roles in endoplasmic reticulum...
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Opposing USP19 splice variants in TGF-β signaling and TGF-β-induced epithelial–mesenchymal transition of breast cancer cells
Ubiquitin-specific protease (USP)19 is a deubiquitinating enzyme that regulates the stability and function of multiple proteins, thereby controlling...
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A cell-to-patient machine learning transfer approach uncovers novel basal-like breast cancer prognostic markers amongst alternative splice variants
BackgroundBreast cancer is amongst the 10 first causes of death in women worldwide. Around 20% of patients are misdiagnosed leading to early...
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USP39 promotes hepatocellular carcinogenesis through regulating alternative splicing in cooperation with SRSF6/HNRNPC
Abnormal alternative splicing (AS) caused by alterations in spliceosomal factors is implicated in cancers. Standard models posit that splice site...
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Peculiarities of Endoplasmic Reticulum Stress Regulator XBP1 Expression in the Gut-Associated Lymphoid Tissue of Wistar Rats under Chronic Stress
AbstractChronic social stress (CSS) can cause physiological disturbances, provoking the development of depression and anxiety, and...
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Milk fat-globule epidermal growth factor 8: A potential Regulator of Cutaneous Wound Healing
Destroying the integrity of the skin may causes disability and even death from injury or illness. Wound healing is a core mechanism to maintain skin...
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Semaphorin3f as a cardiomyocyte derived regulator of heart chamber development
BackgroundDuring development a pool of precursors form a heart with atrial and ventricular chambers that exhibit distinct transcriptional and...
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A transient in planta editing assay identifies specific binding of the splicing regulator PTB as a prerequisite for cassette exon inclusion
The dynamic interaction of RNA-binding proteins (RBPs) with their target RNAs contributes to the diversity of ribonucleoprotein (RNP) complexes that...
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SETD2: from chromatin modifier to multipronged regulator of the genome and beyond
Histone modifying enzymes play critical roles in many key cellular processes and are appealing proteins for targeting by small molecules in disease....
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Alternative splicing shapes the transcriptome complexity in blackgram [Vigna mungo (L.) Hepper]
Vigna mungo , a highly consumed crop in the pan-Asian countries, is vulnerable to several biotic and abiotic stresses. Understanding the...
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The Arabidopsis splicing regulator SR45 confers salt tolerance in a splice isoform-dependent manner
Key messageFunctions of most splice isoforms that are generated by alternative splicing are unknown. We show that two splice variants that encode...
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The multifunctional RNA-binding protein Staufen1: an emerging regulator of oncogenesis through its various roles in key cellular events
The double-stranded multifunctional RNA-binding protein (dsRBP) Staufen was initially discovered in insects as a regulator of mRNA localization....
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Control of mammalian gene expression by modulation of polyA signal cleavage at 5′ UTR
The ability to control gene expression in mammalian cells is crucial for safe and efficacious gene therapies and for elucidating gene functions....
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Variations of intronic branchpoint motif: identification and functional implications in splicing and disease
The branchpoint (BP) motif is an essential intronic element for spliceosomal pre-mRNA splicing. In mammals, its sequence composition, distance to the...
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Modification of BCLX pre-mRNA splicing has antitumor efficacy alone or in combination with radiotherapy in human glioblastoma cells
Dysregulation of anti-apoptotic and pro-apoptotic protein isoforms arising from aberrant splicing is a crucial hallmark of cancers and may contribute...
