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Genetic Variations in Spike Protein: Linking SARS-CoV-2 Variants to Clinical Outcomes
The COVID-19 pandemic has witnessed the emergence of diverse variants of SARS-CoV-2, with spike proteins playing a pivotal role in mutation due to...
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Detection of SARS-CoV-2 spike protein D614G mutation using μTGGE
BackgroundThe accurate and expeditious detection of SARS-CoV-2 mutations is critical for monitoring viral evolution, assessing its impact on...
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Autobahn der Zelle: Wie das SARS-CoV-2-Spike-Protein durch die Zelle reist
Viruses employ cellular host factors not only for replication and transcription but also for transport and assembly. Rab-GTPases, as master...
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Development of a Series of Neutralizing Nanobodies against SARS-CoV-2 Spike Protein
Countering the spread of new respiratory infections and reducing the damage they cause to society requires efficient strategies for rapidly...
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SARS-CoV-2 spike protein promotes inflammatory cytokine activation and aggravates rheumatoid arthritis
BackgroundCoronavirus disease 2019 (COVID-19) induces inflammation, autoantibody production, and thrombosis, which are common symptoms of autoimmune...
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SARS-CoV-2 spike protein S1 activates Cx43 hemichannels and disturbs intracellular Ca2+ dynamics
BackgroundSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the ongoing coronavirus disease 2019 (COVID-19). An aspect of high...
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SARS CoV-2 spike protein variants exploit DC-SIGN/DC-SIGNR receptor for evolution and severity: an in-silico insight
The Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is related with the COVID-19 pandemic. Recent spike protein variations have had an...
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Designing a Novel Spike Linear B-Cell Epitopes (SLBE) Protein with High Performance in Sars-Cov2-ELISA Test
SARS-CoV2 spike glycoprotein acting a key role in the infection and transmission of coronaviruses. Spike glycoprotein is the target for the...
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Molecular mimicry of the receptor-binding domain of the SARS-CoV-2 spike protein: from the interaction of spike-specific antibodies with transferrin and lactoferrin to the antiviral effects of human recombinant lactoferrin
The pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection involves dysregulations of iron metabolism, and although...
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Structural and functional characteristics of the SARS-CoV-2 Omicron subvariant BA.2 spike protein
The Omicron subvariant BA.2 has become the dominant circulating strain of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in many...
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Enumeration of olive derived lignan, pinoresinol for activity against recent Omicron variant spike protein for structure-based drug design, DFT, molecular dynamics simulations, and MMGBSA studies
The coronavirus disease 2019 (COVID-19) was first found in Wuhan, China, in December 2019. Because the virus spreads quickly, it quickly became a...
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Recombinant RBD of the SARS-CoV-2 Spike Protein: Production in Escherichia coli Cells, Binding to Antibodies, and Antiviral Activity
AbstractThe aim of the study is to synthesize a recombinant protein in Escherichia coli cells that carries the receptor-binding domain (RBD) of...
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Spike RBDs Binding with 50 Drugs
Shaw et al. (2020) selected 5152 drug molecules from the FDA drug library and found that during 2...
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Spike (S) Glycoprotein
Coronavirus SARS-CoV-2 spike glycoproteins (S-proteins) promote entry into cells and are the main target of antibodies and inhibitors....
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Inhibition of IRAK4 dysregulates SARS-CoV-2 spike protein-induced macrophage inflammatory and glycolytic reprogramming
Escalated innate immunity plays a critical role in SARS-CoV-2 pathology; however, the molecular mechanism is incompletely understood. Thus, we aim to...
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Immunodominant conserved moieties on spike protein of SARS-CoV-2 renders virulence factor for the design of epitope-based peptide vaccines
The outbreak of novel SARS-CoV-2 virion has wreaked havoc with a high prevalence of respiratory illness and high transmission due to a vague...
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SARS-COV-2 spike protein promotes RPE cell senescence via the ROS/P53/P21 pathway
SARS-Cov-2 infection, which has caused the COVID-19 global pandemic, triggers cellular senescence. In this study, we investigate the role of the...
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Spike (S) Glycoprotein N501Y Mutant
SARS-CoV-2 worldwide pandemic was once attributed to the mutations in the receptor-binding domain (RBD), the area that directly contacts human ACE2;...
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SARS-CoV-2 omicron variants harbor spike protein mutations responsible for their attenuated fusogenic phenotype
Since the emergence of the Omicron variants at the end of 2021, they quickly became the dominant variants globally. The Omicron variants may be more...
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Spike protein of SARS-CoV-2 variants: a brief review and practical implications
The scientific community has been alarmed by the possible immunological evasion, higher infectivity, and severity of disease caused by the newest...
