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Spem2, a novel testis-enriched gene, is required for spermiogenesis and fertilization in mice
Spermiogenesis is considered to be crucial for the production of haploid spermatozoa with normal morphology, structure and function, but the...
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PDCL2 is essential for spermiogenesis and male fertility in mice
Patients with teratozoospermia exhibit low phosducin-like protein ( Pdcl2 ) expression. As a member of the phosducin family, chaperonin-related Pdcl2 ,...
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CDKN2AIP is critical for spermiogenesis and germ cell development
BackgroundAs a member of RNA-binding protein, CDKN2AIP has been shown to play a critical role in stem cell pluripotency and somatic differentiation....
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The potential function of KIF17 in large yellow croaker (Larimichthys crocea) spermatid remodeling: molecular characterization and expression pattern during spermiogenesis
KIF17, which belongs to the kinesin-2 protein family, plays an indispensable role in mammalian spermiogenesis. However, the role of KIF17 in fish...
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AXDND1, a novel testis-enriched gene, is required for spermiogenesis and male fertility
Spermiogenesis is a complex process depending on the sophisticated coordination of a myriad of testis-enriched gene regulations. The regulatory...
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WDR62 is required for centriole duplication in spermatogenesis and manchette removal in spermiogenesis
WDR62 is a scaffold protein involved in centriole duplication and spindle assembly during mitosis. Mutations in WDR62 can cause primary microcephaly...
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miR-199-5p regulates spermiogenesis at the posttranscriptional level via targeting Tekt1 in allotriploid crucian carp
BackgroundSperm abnormalities are one of the primary factors leading to male sterility, but their pathogenesis is still unclear. Although miRNAs are...
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Loss of CEP70 function affects acrosome biogenesis and flagella formation during spermiogenesis
The spermatogenesis process is complex and delicate, and any error in a step may cause spermatogenesis arrest and even male infertility. According to...
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Regulation of Miwi-mediated mRNA stabilization by Ck137956/Tssa is essential for male fertility
BackgroundSperm is formed through spermiogenesis, a highly complex process involving chromatin condensation that results in cessation of...
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CCDC146 is required for sperm flagellum biogenesis and male fertility in mice
Multiple morphological abnormalities of the flagella (MMAF) is a severe disease of male infertility, while the pathogenetic mechanisms of MMAF are...
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Analysis of Morphogenesis and Flagellar Assembly During Spermatogenesis in Planarian Flatworms
Spermatogenesis is one of the most dramatic cellular differentiation events observed in animals. In particular, spermiogenesis (the final stage of...
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Expression and potential functions of KIF3A/3B to promote nuclear resha** and tail formation during Larimichthys polyactis spermiogenesis
KIF3A and KIF3B are homologous motor subunits of the Kinesin II protein family. KIF3A, KIF3B, and KAP3 form a heterotrimeric complex and play a...
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In the Sea of Japan and the Adriatic Sea, a COX1 DNA test revealed genetic similarity of Manila clams, although shell parameters, spermatogenesis patterns, and sperm characteristics are area specific
The two Manila clam forms living in the Sea of Japan and in the Adriatic Sea were compared genetically and morphologically to identify traits that...
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Transcriptome analysis of reproductive tract tissues of male river prawn Macrobrachium americanum
BackgroundThe river prawn, Macrobrachium americanum (M. americanum), is one of the largest prawns of the genus in Latin America and is an...
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Parental competition for the regulators of chromatin dynamics in mouse zygotes
The underlying mechanism for parental asymmetric chromatin dynamics is still unclear. To reveal this, we investigate chromatin dynamics in...
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Sperm chromatin structure and reproductive fitness are altered by substitution of a single amino acid in mouse protamine 1
Conventional dogma presumes that protamine-mediated DNA compaction in sperm is achieved by electrostatic interactions between DNA and the...
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Diversity of chromatin condensation patterns, nuclear reorganization, evolution and phylogenetic distribution of sperm nuclear basic proteins in fish
One of the most astonishing examples of chromatin remodelling occurs during the maturation of male germ cells, where changes in protein structure, as...
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The testis-specific E3 ubiquitin ligase RNF133 is required for fecundity in mice
BackgroundUbiquitination is a post-translational modification required for a number of physiological functions regulating protein homeostasis, such...
