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1. Enhancer Arrays Regulating Developmental Genes: Sox2 Enhancers as a Paradigm

   EnhancersEnhancers are the primary regulatory DNA sequences in eukaryotes and are mostly located in the non-coding sequencesnon-coding sequences of...

   Hisato Kondoh in Molecular Basis of Developmental and Stem Cell Regulation

   Chapter 2024
   

2. Mammalian esophageal stratified tissue homeostasis is maintained distinctively by the epithelial pluripotent p63⁺Sox2⁺ and p63⁻Sox2⁺ cell populations

   Self-renewing, damage–repair and differentiation of mammalian stratified squamous epithelia are subject to tissue homeostasis, but the regulation...

   **aohong Yu, Hui Yuan, ... **ying Yu in Cellular and Molecular Life Sciences

   Article 26 September 2023
   

3. SOX2 promotes vasculogenic mimicry by accelerating glycolysis via the lncRNA AC005392.2-GLUT1 axis in colorectal cancer

   Vasculogenic mimicry (VM), a new model of angiogenesis, fulfills the metabolic demands of solid tumors and contributes to tumor aggressiveness. Our...

   Shimiao Huang, Xuan Wang, ... Haoxuan Zheng in Cell Death & Disease

   Article Open access 04 December 2023
   

4. SOX2 and OCT4 mediate radiation and drug resistance in pancreatic tumor organoids

   Pancreatic cancer has a five-year survival rate of only 10%, mostly due to late diagnosis and limited treatment options. In patients with...

   Sanjit Roy, Tijana Dukic, ... Hem D. Shukla in Cell Death Discovery

   Article Open access 01 March 2024
   

5. Knocking down SOX2 overcomes the resistance of prostate cancer to castration via notch signaling

   Background

   Castration-resistant prostate cancer (CRPC) is a terminal type of advanced cancer resistant to androgen deprivation therapy (ADT). Due to...

   Zhongbo Du, **aobin Chen, ... Junqing Gu in Molecular Biology Reports

   Article 16 September 2023
   

6. Deubiquitinase PSMD7 facilitates pancreatic cancer progression through activating Nocth1 pathway via modifying SOX2 degradation

   Background

   Ubiquitination is a critical post-translational modification which can be reversed with an enzyme family known as deubiquitinating enzymes...

   Chen Luo, Yi Yu, ... Rongfa Yuan in Cell & Bioscience

   Article Open access 17 March 2024
   

7. Targeting the SOX2/CDP protein complex with a peptide suppresses the malignant progression of esophageal squamous cell carcinoma

   Emerging evidence indicates that SOX2 is an oncogene for esophageal squamous cell carcinoma (ESCC). However, direct targeting of SOX2 is not feasible...

   Yunyun Chen, Kun Zhang, ... Kuancan Liu in Cell Death Discovery

   Article Open access 27 October 2023
   

8. LncRNA WAC-AS1 promotes osteosarcoma Metastasis and stemness by sponging miR-5047 to upregulate SOX2

   Cancer stemness and osteosarcoma (OS) malignant progression are closely associated. However, the molecular mechanisms underlying this association...

   Zhining Yang, Zhaoyong Liu, ... Ying Zhang in Biology Direct

   Article Open access 14 November 2023
   

9. Reciprocal regulation of LINC00941 and SOX2 promotes progression of esophageal squamous cell carcinoma

   LINC00941 is a novel long noncoding RNA (lncRNA) and emerging as an important factor in cancer development. However, the exact function and relative...

   Jun-Tao Lu, Zhao-Yang Yan, ... Wei Guo in Cell Death & Disease

   Article Open access 30 January 2023
   

10. PVT1/miR-136/Sox2/UPF1 axis regulates the malignant phenotypes of endometrial cancer stem cells

    Tumor stem cells (TSCs) are thought to contribute to the progression and maintenance of cancer. Previous studies have suggested that plasmacytoma...

    Qing Li, Fanfei Kong, ... **aoxin Ma in Cell Death & Disease

    Article Open access 03 March 2023
    

11. Self-restricted circular RNA circSOX2 suppressed the malignant progression in SOX2-amplified LUSC

    Lung squamous cell carcinoma (LUSC) is a histological subtype of non-small cell lung cancer with the worse progression. SRY-Box Transcription Factor...

    Yingkuan Liang, Nan Wang, ... Gaochao Dong in Cell Death & Disease

    Article Open access 15 October 2022
    

12. SOX2 suppresses osteoblast differentiation of MC3T3-E1 cells through activating the transcription of LGR4

    Osteogenic differentiation is a crucial process of new bone formation. This study aimed to explore the roles and mechanism of SRY-Box Transcription...

    Sunyu Chen, Zhanhao **ao, Wen** Jiang in In Vitro Cellular & Developmental Biology - Animal

    Article 22 December 2022
    

13. Distinct roles for SOX2 and SOX21 in differentiation, distribution and maturation of pulmonary neuroendocrine cells

    Pulmonary neuroendocrine (NE) cells represent a small population in the airway epithelium, but despite this, hyperplasia of NE cells is associated...

    Evelien Eenjes, Floor Benthem, ... Robbert J. Rottier in Cellular and Molecular Life Sciences

    Article Open access 03 March 2023
    

14. Hypoxia increases RCC stem cell phenotype via altering the androgen receptor (AR)-lncTCFL5-2-YBX1-SOX2 signaling axis

    Background

    Early studies indicated that the androgen receptor (AR) could promote renal cell carcinoma (RCC) development and metastasis, but its...

    Changcheng Guo, Yin Sun, ... Chawnshang Chang in Cell & Bioscience

    Article Open access 17 November 2022
    

15. Coupled fibromodulin and SOX2 signaling as a critical regulator of metastatic outgrowth in melanoma

    We aimed to study mechanisms controlling metastatic outgrowth of melanoma into clinically relevant lesions, a critical process responsible for the...

    Victor O. Oria, Hongyi Zhang, ... Lucia B. Jilaveanu in Cellular and Molecular Life Sciences

    Article Open access 23 June 2022
    

16. Distinct gene expression patterns of SOX2 and SOX2OT variants in different types of brain tumours

    Numerous investigations have been recently published on the dysregulated expression of long-noncoding RNAs (lncRNAs) in various cancer types,...

    Youssef Fouani, Akram Gholipour, ... Mahshid Malakootian in Journal of Genetics

    Article 27 March 2023
    

17. Sox2 levels regulate the chromatin occupancy of WNT mediators in epiblast progenitors responsible for vertebrate body formation

    WNT signalling has multiple roles. It maintains pluripotency of embryonic stem cells, assigns posterior identity in the epiblast and induces...

    Robert Blassberg, Harshil Patel, ... James Briscoe in Nature Cell Biology

    Article Open access 12 May 2022
    

18. The rates of adult neurogenesis and oligodendrogenesis are linked to cell cycle regulation through p27-dependent gene repression of SOX2

    Cell differentiation involves profound changes in global gene expression that often has to occur in coordination with cell cycle exit. Because...

    Ana Domingo-Muelas, Jose Manuel Morante-Redolat, ... Isabel Fariñas in Cellular and Molecular Life Sciences

    Article Open access 11 January 2023
    

19. Persistence of FoxJ1⁺ Pax6⁺ Sox2⁺ ependymal cells throughout life in the human spinal cord

    Ependymal cells lining the central canal of the spinal cord play a crucial role in providing a physical barrier and in the circulation of...

    Chantal Ripoll, Gaetan Poulen, ... Jean-Philippe Hugnot in Cellular and Molecular Life Sciences

    Article 17 June 2023
    

20. Induction of RAC1 protein translation and MKK7/JNK-dependent autophagy through dicer/miR-145/SOX2/miR-365a axis contributes to isorhapontigenin (ISO) inhibition of human bladder cancer invasion

    Although our previous studies have identified that isorhapontigenin (ISO) is able to initiate autophagy in human bladder cancer (BC) cells by...

    **aohui Hua, Daimin **ang, ... Chuanshu Huang in Cell Death & Disease

    Article Open access 31 August 2022