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Neuropeptides and small-molecule amine transmitters: cooperative signaling in the nervous system
Neuropeptides are expressed in cell-specific patterns throughout mammalian brain. Neuropeptide gene expression has been useful for clustering neurons...
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Biogenic Monoamines in the Control of Triatomine Physiology with Emphasis on Rhodnius prolixus
The biogenic monoamines, serotonin, octopamine, tyramine, dopamine and histamine are present within insect nervous systems, where they modulate...
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Oxidative stress signalling
Oxidative stress arises from an imbalance in the generation and removal of reactive oxygen species (ROS) within cells. ROS are produced during...
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Defensive Strategies of ROS in Plant–Pathogen Interactions
Plants have an array of mechanisms that protect them against the impact of biotic and abiotic factors. As a consequence, the altered redox cue of the...
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Silica-Based Advanced Nanoparticles For Treating Ischemic Disease
Recently, various attempts have been made to apply diverse types of nanoparticles in biotechnology. Silica nanoparticles (SNPs) have been highlighted...
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Pharmacological inactivation of the prion protein by targeting a folding intermediate
Recent computational advancements in the simulation of biochemical processes allow investigating the mechanisms involved in protein regulation with...
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Spatial visualization of comprehensive brain neurotransmitter systems and neuroactive substances by selective in situ chemical derivatization mass spectrometry imaging
Molecule-specific techniques such as MALDI and desorption electrospray ionization mass spectrometry imaging enable direct and simultaneous map** of...
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Biological Activities of the Alkaloids of the Calabar Bean
Ach (180) is the cationic neurotransmitter that in the central and peripheral nervous systems effects the transmission of action potentials across...
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The cytosolic thiol peroxidase PRXIIB is an intracellular sensor for H2O2 that regulates plant immunity through a redox relay
Rapid production of H 2 O 2 is a hallmark of plant responses to diverse pathogens and plays a crucial role in signalling downstream of various receptors...
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Cellular heterogeneity of pluripotent stem cell-derived cardiomyocyte grafts is mechanistically linked to treatable arrhythmias
Preclinical data have confirmed that human pluripotent stem cell-derived cardiomyocytes (PSC-CMs) can remuscularize the injured or diseased heart,...
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Fish gill chemosensing: knowledge gaps and inconsistencies
In this review, we explore the inconsistencies in the data and gaps in our knowledge that exist in what is currently known regarding gill...
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Ischemia–Reperfusion Injury: Molecular Mechanisms of Pathogenesis and Methods of Their Correction
Abstract —Ischemia–reperfusion is a cascade of complex and interrelated pathological processes underlying many human diseases, including such socially...
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DART.2: bidirectional synaptic pharmacology with thousandfold cellular specificity
Precision pharmacology aims to manipulate specific cellular interactions within complex tissues. In this pursuit, we introduce DART.2 (drug acutely...
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Nitric oxide, crosstalk with stress regulators and plant abiotic stress tolerance
Key messageNitric oxide is a dynamic gaseous molecule involved in signalling, crosstalk with stress regulators, and plant abiotic-stress responses....
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Current Approaches to the Search of Anxiolytic Drugs
Abstract—This article presents a review of studies of new pharmacological substances in the aspect of their anxiolytic activity. These substances are...
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Glycoconjugate journal special issue on: the glycobiology of Parkinson’s disease
Parkinson’s disease (PD) is a neurodegenerative disorder that affects over 10 million aging people worldwide. This condition is characterized by the...
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The Role of Selenium in Human Nutrition
This chapter is devoted to selenium and its role in organism. Selenium has been proved as an essential element for animals and humans. Perception of...
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Biosensors and Nanobiosensors in Environmental Applications
There is a big demand for fast, reliable, and low-cost systems for the detection, monitoring, and diagnosis of pollutant in the environment and...
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Nanoscale fiber-optic force sensors for mechanical probing at the molecular and cellular level
There is an ongoing need to develop ultrasensitive nanomechanical instrumentation that has high spatial and force resolution, as well as an ability...
