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Ginsenoside Rb3 attenuates skin flap ischemia-reperfusion damage by inhibiting STING-IRF3 signaling
We investigate the protective effect of ginsenoside Rb3 on skin flap microvasculature following ischemia-reperfusion (I/R) injury and its regulatory...
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Oxidative stress-induced endothelial cells-derived exosomes accelerate skin flap survival through Lnc NEAT1-mediated promotion of endothelial progenitor cell function
BackgroundFlap transplantation is commonly used in reconstructive surgery. A prerequisite for skin flap survival is sufficient blood supply. However,...
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Dynamic alterations in M2 macrophage subtypes enhance flap expansion efficiency and tissue regeneration
Dilatation of soft skin tissue is a common surgical procedure in plastic surgery. M2 macrophages play a critical role in reducing inflammation,...
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Preclinical efficacy of stem cell therapy for skin flap: a systematic review and meta-analysis
BackgroundA skin flap is one of the most critical surgical techniques for the restoration of cutaneous defects. However, the distal necrosis of the...
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Activating Parkin-dependent mitophagy alleviates oxidative stress, apoptosis, and promotes random-pattern skin flaps survival
The random-pattern skin flap is a crucial technique in reconstructive surgery and flap necrosis caused by ischemia/reperfusion injury is a major...
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Association of a Skin Dressing Made With the Organic Part of Marine Sponges and Photobiomodulation on the Wound Healing in an Animal Model
The present study aims to characterize and to evaluate the biological effects of a skin dressing manufactured with the organic part of the Chondrilla...
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Multiple Injections of Adipose-Derived Stem Cells Improve Graft Survival in Human-to-Rat Skin Xenotransplantation through Immune Modulation
Background:Adipose-derived stem cells (ADSCs) exert immunomodulatory effects in the treatment of transplant rejection. This study aimed to evaluate...
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Recent Progress in Mesenchymal Stem Cell-Derived Exosomes for Skin Wound Repair
Background: Exosomes are nanometer-sized, lipid bilayer membrane vesicles that are secreted by various cell types. Mesenchymal stem cells (MSCs) have...
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A dopamine-methacrylated hyaluronic acid hydrogel as an effective carrier for stem cells in skin regeneration therapy
Adipose-derived stem cells (ADSCs) show potential in skin regeneration research. A previous study reported the failure of full-thickness skin...
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Xenotransplantation of a Full-Layer Human Skin Strip as a Model for Studying Skin Regeneration and the Hair Follicle Cycle
AbstractXenotransplantation of skin transplants from humans to animals with immunodeficiency is one of the most successful models for studying human...
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A randomized, controlled clinical trial of autologous stromal vascular fraction cells transplantation to promote mechanical stretch-induced skin regeneration
BackgroundThe regeneration response of the skin to mechanical stretching in vivo has been explored in reconstructive surgery to repair large-scale...
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Skin T cells maintain their diversity and functionality in the elderly
Recent studies have highlighted that human resident memory T cells (T RM ) are functionally distinct from circulating T cells. Thus, it can be...
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FGF21 augments autophagy in random-pattern skin flaps via AMPK signaling pathways and improves tissue survival
Random-pattern skin flap is commonly used for surgical tissue reconstruction due to its ease and lack of axial vascular limitation. However, ischemic...
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Intravital microscopy of dynamic single-cell behavior in mouse mammary tissue
Multiphoton intravital imaging is essential for understanding cellular behavior and function in vivo. The adipose-rich environment of the mammary...
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Trehalose promotes the survival of random-pattern skin flaps by TFEB mediated autophagy enhancement
Random-pattern skin flaps are commonly used and valuable tools in reconstructive surgery, however, post-operative random skin flap necrosis remains a...
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Cardioprotective Effect of Soy Protein on a High-Salt Diet in Cynomolgus Monkeys
AbstractExcessive salt intake is accompanied by the development of cardiovascular disorders, not always associated with an increase in blood pressure...
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Synanceia quinque, a new species of stonefish (Synanceiidae) from Borneo and Flores
A new species of stonefish, Synanceia quinque (Synanceiidae) is described on the basis of two specimens (61.5–84.4 mm standard length) collected off...
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An Important Role of Macrophages for Wound Margin Regeneration in a Murine Flap Model
Background:Macrophages have been known to have diverse roles either after tissue damage or during the wound healing process; however, their roles in...
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The therapeutic effect of adipose-derived stem cells on soft tissue injury after radiotherapy and their value for breast reconstruction
BackgroundPostmastectomy radiotherapy is considered to be a necessary treatment in the therapy of breast cancer, while it will cause soft tissue...
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Organ Bioluminescence Imaging Under Machine Perfusion Setting for Assessing Quality of Harvested Organ Preservation
Determination of organ viability over a period of time is a key technology in the process of organ preservation. However, a robust methodology to...