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Site-and-branch-heterogeneous analyses of an expanded dataset favour mitochondria as sister to known Alphaproteobacteria
Determining the phylogenetic origin of mitochondria is key to understanding the ancestral mitochondrial symbiosis and its role in eukaryogenesis....
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Identifying priorities under highly heterogeneous environments through species distribution models to facilitate orchid conservation
The ecological suitability prediction and analysis of specific taxonomic groups at finer geographic scales provide vital references for identifying...
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Can machine learning models provide accurate fertilizer recommendations?
Accurate modeling of site-specific crop yield response is key to providing farmers with accurate site-specific economically optimal input rates...
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Occupancy models with autocorrelated detection heterogeneity
Occupancy models are commonly used in statistical ecology to model binary detection/non-detection data. These hierarchical models make a distinction...
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Improving the study of plant evolution with multi-matrix mixture models
Amino acid substitution model is a key component to study the plant evolution from protein sequences. Although single-matrix amino acid substitution...
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OBSERVE: guidelines for the refinement of rodent cancer models
Existing guidelines on the preparation (Planning Research and Experimental Procedures on Animals: Recommendations for Excellence (PREPARE)) and...
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Extra-Skeletal Manifestations in Osteogenesis Imperfecta Mouse Models
Osteogenesis imperfecta (OI) is a rare heritable connective tissue disorder of skeletal fragility with an incidence of roughly 1:15,000....
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Experimental Zebrafish Models of Mitochondrial Dysfunction in the Pathogenesis of CNS Diseases
AbstractMitochondrial dysfunctions are associated with pathogenesis of various brain disorders, including Alzheimer’s, Parkinson’s and Huntington’s...
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Translational Utility of Organoid Models for Biomedical Research on Gastrointestinal Diseases
AbstractOrganoid models have recently been utilized to study 3D human-derived tissue systems to uncover tissue architecture and adult stem...
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Within-Host Mathematical Models of Antibiotic Resistance
Mathematical models have been used to study the spread of infectious diseases from person to person. More recently studies are develo** within-host...
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An Update on Animal Models of Osteogenesis Imperfecta
Osteogenesis imperfecta (OI) is a heterogeneous disorder characterized by bone fragility, multiple fractures, bone deformity, and short stature. In...
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Models to estimate genetic gain of soybean seed yield from annual multi-environment field trials
Key messageSimulations demonstrated that estimates of realized genetic gain from linear mixed models using regional trials are biased to some degree....
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Non-classical animal models for studying adrenal diseases: advantages, limitations, and implications for research
The study of adrenal disorders is a key component of scientific research, driven by the complex innervation, unique structure, and essential...
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Application of linear mixed models for multiple harvest/site trial analyses in perennial plant breeding
The optimization of perennial plant breeding necessarily involves the evaluation of multi-harvest and/or multi-site trials. In these situations,...
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Animal models to study the neurological manifestations of the post-COVID-19 condition
More than 40% of individuals infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have experienced persistent or relapsing...
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From leaf to multiscale models of photosynthesis: applications and challenges for crop improvement
To keep up with the growth of human population and to circumvent deleterious effects of global climate change, it is essential to enhance crop yield...
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Forecasting natural regeneration of sagebrush after wildfires using population models and spatial matching
ContextAddressing ecosystem degradation in the Anthropocene will require ecological restoration across large spatial extents. Identifying areas where...
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Astrocytes: new evidence, new models, new roles
Astrocytes have been in the limelight of active research for about 3 decades now. Over this period, ideas about their function and role in the...
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Large-landscape connectivity models for pond-dwelling species: methods and application to two invasive amphibians of global concern
ContextFunctional connectivity models are essential in identifying major dispersal pathways and develo** effective management strategies for...
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Large language models generate functional protein sequences across diverse families
Deep-learning language models have shown promise in various biotechnological applications, including protein design and engineering. Here we describe...
